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94 Possible Causes for Massive Splenomegaly, Pancytopenia, Thromboembolism

  • Paroxysmal Nocturnal Hemoglobinuria

    KEYWORDS: Paroxysmal nocturnal hemoglobinuria; Venous thromboembolism[] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[]

  • Primary Myelofibrosis

    During initial stages of the disease, thrombocytosis accounts for symptoms like thrombosis and thromboembolism.[] She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[]

  • Chronic Myeloid Leukemia

    […] tyrosine kinase inhibitor treatment, the main goal was to reduce the leukocyte count to postpone delivery beyond the number of weeks considered severely premature and avoid thromboembolic[] Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly.[] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[]

  • Myeloproliferative Disease

    BACKGROUND: Splenectomy is a risk factor for both portal-vein and chronic thromboembolic pulmonary hypertension.[] Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    There were no major thromboembolic or bleeding events.[] […] included thrombocytopenia (n 8), diarrhea (n 3), alanine aminotransferase elevation (n 3), aspartate aminotransferase elevation (n 2), dyspnea (n 2), neutropenia (n 2), pancytopenia[]

  • Chronic Phase of Chronic Myeloid Leukemia

    Ann Hematol. 2018 Sep;97(9):1577-1580. doi: 10.1007/s00277-018-3337-2. Epub 2018 Apr 19. Breccia M 1 , Abruzzese E 2 , Castagnetti F 3 , Bonifacio M 4 , Gangemi D 5 , Sorà F 6 , Iurlo A 7 , Luciano L 8 , Gozzini A 9 , Gentile M 10 , Bocchia M 11 , Luzi D 12 , Maggi A 13 , Sgherza N 14 , Isidori A 15 , Crugnola M 16 , Pregno P[…][]

  • Mantle Cell Lymphoma

    Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[] Severe adverse events included 2 thromboembolic events and 1 grade IV neutropenia associated with thalidomide.[] […] in cancer patients Symptomatic venous thromboembolism occurs 4–7 times more frequently Blastic plasmacytoid dendritic cell neoplasm: case report and literature review Blastic[]

  • Chronic Lymphocytic Leukemia

    […] treatment may confuse the suspicion of AHA and its diagnosis; b) hemorrhagic pericardial effusion is an extremely rare presentation; c) bypassing agents raise the risk of thromboembolism[] splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[]

  • Hairy Cell Leukemia

    Muge Gunalp, Enver Atalar, Figen Coskun, Arda Yilmaz, Serdar Aksoyek, Nalan Metin Aksu and Bulent Sivri, Holter monitoring for 24 hours in patients with thromboembolic stroke[] Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[] We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.[]

  • Familial Myelofibrosis

    Massive splenomegaly 22 cm may predict TRM and relapse (Bacigalupo et al, 2010 ).[] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[] Pancytopenia and leukoerythroblastosis require further clarification and should prompt a bone marrow biopsy.[]

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