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94 Possible Causes for Massive Splenomegaly, Pancytopenia, Thromboembolism

  • Paroxysmal Nocturnal Hemoglobinuria

    KEYWORDS: Paroxysmal nocturnal hemoglobinuria; Venous thromboembolism[ncbi.nlm.nih.gov] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    During initial stages of the disease, thrombocytosis accounts for symptoms like thrombosis and thromboembolism.[symptoma.com] She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Chronic Myeloid Leukemia

    […] tyrosine kinase inhibitor treatment, the main goal was to reduce the leukocyte count to postpone delivery beyond the number of weeks considered severely premature and avoid thromboembolic[ncbi.nlm.nih.gov] Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly.[ncbi.nlm.nih.gov] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    BACKGROUND: Splenectomy is a risk factor for both portal-vein and chronic thromboembolic pulmonary hypertension.[ncbi.nlm.nih.gov] Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    There were no major thromboembolic or bleeding events.[gotoper.com] […] included thrombocytopenia (n 8), diarrhea (n 3), alanine aminotransferase elevation (n 3), aspartate aminotransferase elevation (n 2), dyspnea (n 2), neutropenia (n 2), pancytopenia[bloodjournal.org]

  • Chronic Phase of Chronic Myeloid Leukemia

    Ann Hematol. 2018 Sep;97(9):1577-1580. doi: 10.1007/s00277-018-3337-2. Epub 2018 Apr 19. Breccia M 1 , Abruzzese E 2 , Castagnetti F 3 , Bonifacio M 4 , Gangemi D 5 , Sorà F 6 , Iurlo A 7 , Luciano L 8 , Gozzini A 9 , Gentile M 10 , Bocchia M 11 , Luzi D 12 , Maggi A 13 , Sgherza N 14 , Isidori A 15 , Crugnola M 16 , Pregno P[…][ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[symptoma.com] Severe adverse events included 2 thromboembolic events and 1 grade IV neutropenia associated with thalidomide.[ncbi.nlm.nih.gov] […] in cancer patients Symptomatic venous thromboembolism occurs 4–7 times more frequently Blastic plasmacytoid dendritic cell neoplasm: case report and literature review Blastic[prolekare.cz]

  • Chronic Lymphocytic Leukemia

    […] treatment may confuse the suspicion of AHA and its diagnosis; b) hemorrhagic pericardial effusion is an extremely rare presentation; c) bypassing agents raise the risk of thromboembolism[ncbi.nlm.nih.gov] splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Muge Gunalp, Enver Atalar, Figen Coskun, Arda Yilmaz, Serdar Aksoyek, Nalan Metin Aksu and Bulent Sivri, Holter monitoring for 24 hours in patients with thromboembolic stroke[doi.org] Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    Massive splenomegaly 22 cm may predict TRM and relapse (Bacigalupo et al, 2010 ).[onlinelibrary.wiley.com] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov] Pancytopenia and leukoerythroblastosis require further clarification and should prompt a bone marrow biopsy.[symptoma.com]

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