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50 Possible Causes for Massive Splenomegaly, Pancytopenia, Vertigo

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by progressive anemia, massive splenomegaly, leukoerythroblastosis, extramedullary hematopoiesis[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com]

  • Myeloproliferative Disease

    Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] Clinical description Symptoms are often insidious at onset and may include headache, dizziness, vertigo, tinnitus, visual disturbances, and pruritus after bathing, a ruddy[orpha.net] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com]

  • Chronic Lymphocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov]

  • Leukemia

    Splenomegaly can be massive, consistency high, with the fibrous thickening of the capsule.[ncbi.nlm.nih.gov] This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com] MRI of the brain, to look into symptoms such as confusion, paralysis, numbness, vision problems, vertigo, or headaches.[healthlinkbc.ca]

  • Chronic Myeloid Leukemia

    Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly.[ncbi.nlm.nih.gov] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov] The objective was to describe a unique case of sudden bilateral hearing loss, tinnitus, and vertigo presenting as the first symptoms of chronic myeloid leukemia (CML).[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    Massive splenomegaly 22 cm may predict TRM and relapse (Bacigalupo et al, 2010 ).[onlinelibrary.wiley.com] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov] Pancytopenia and leukoerythroblastosis require further clarification and should prompt a bone marrow biopsy.[symptoma.com]

  • Disseminated Histoplasmosis

    She was complaining from fever, chronic diarrhoea and pancytopenia.[ncbi.nlm.nih.gov] One patient had a history of anorexia, vertigo and fall with severe weight loss. He had hypotension. Only one patient was pregnant while diagnosed to have DH.[mjhid.org] Presenting symptoms included fever, hepatosplenomegaly and pancytopenia. Bone marrow biopsy confirmed HLH.[ncbi.nlm.nih.gov]

  • Leukoerythroblastic Anemia

    Massive splenomegaly can cause abdominal pressure, early satiety, cachexia, portal hypertension, and left upper quadrant abdominal pain; hepatomegaly may be present.[merckmanuals.com] Myeloproliferative Disease, Autosomal Recessive Myeloproliferative Disorder, Chronic, with Eosinophilia myeloproliferative neoplasm neonatal anemia normocytic anemia pancytopenia[rgd.mcw.edu] There is a dull headache, vertigo, buzzing in the ears, spots before the eyes, and weakness of the muscles.[answers.com]

  • Acute Myelocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] The patient with AML showed pancytopenia 2 months before the diagnosis of AML, had a normal karyotype, and showed a good response to chemotherapy.[ncbi.nlm.nih.gov] These two cases of acute leukemia, which developed 3 years after diagnosis of breast cancer and initiation of chemotherapy, were characterized by trilineage dysplasia and pancytopenia[ncbi.nlm.nih.gov]

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