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171 Possible Causes for Massive Splenomegaly, Pancytopenia, Weight Loss

  • Leukemia

    Splenomegaly can be massive, consistency high, with the fibrous thickening of the capsule.[ncbi.nlm.nih.gov] loss (including ‘anorexia’, ‘weight loss’ and ‘anorexia/weight loss’), weakness/fatigue (including ‘weakness’, ‘fatigue’, ‘weakness/fatigue’), malaise/fatigue (including[doi.org] This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] Constitutional symptoms, such as night sweats, pruritus, weight loss and fever may be treated with Jakafi.[mpnresearchfoundation.org] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Chronic Lymphocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] […] of appetite, weight loss, or night sweats Swollen lymph nodes Chemotherapy, including targeted medicines, are used to treat CLL.[nlm.nih.gov] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] Twenty-five years later, the patient presented with weight loss, fatigue, and a large PET-avid mass surrounding the head of the pancreas.[ncbi.nlm.nih.gov] We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly.[ncbi.nlm.nih.gov] Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly.[icd9data.com] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[symptoma.com] We present a middle-aged woman complaining of weakness, lethargy and weight loss for 6 months.[ncbi.nlm.nih.gov] He had fever, night sweats, and weight loss (B-symptoms), along with lymphadenopathy and elevated serum lactate dehydrogenase, with no prior history of lymphoma.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[orpha.net] Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] The clinical picture in early stages is often nonspecific with symptoms including fatigue, weight loss and anorexia.[symptoma.com]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Weight loss, fever, night sweats, and reduced exercise tolerance are common complaints.[symptoma.com] […] included thrombocytopenia (n 8), diarrhea (n 3), alanine aminotransferase elevation (n 3), aspartate aminotransferase elevation (n 2), dyspnea (n 2), neutropenia (n 2), pancytopenia[bloodjournal.org] loss, night sweats or splenomegaly.[orpha.net]

  • Chronic Phase of Chronic Myeloid Leukemia

    In the accelerated phase, the number of CML cells is growing faster and causing symptoms such as fatigue, fever, weight loss and an enlarged spleen.[lls.org] These patients often have fever, poor appetite, and weight loss. In this phase, the CML acts a lot like an acute leukemia.[cancer.org] Patients in blast phase often have a fever, an enlarged spleen, weight loss, and generally feel unwell. Resistant CML.[cancer.net]

  • Hepatosplenic Lymphoma

    Most patients had massive splenomegaly, and bone marrow showed sinusoidal involvement by lymphoma.[mdanderson.elsevierpure.com] loss (for no known reason) Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Splenectomy Progression and Transformation Relapses seen in vast majority[seer.cancer.gov] The doctor and I both thought it was a bowel obstruction, but the cat scan showed an enormous spleen and bloodwork should pancytopenia (low blood counts on everything).[csn.cancer.org]

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