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62 Possible Causes for Massive Splenomegaly, Reticulocytes Increased

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] The percentage of reticulocytes is mildly increased but may vary widely in a given case.[patient-help.com] Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by progressive anemia, massive splenomegaly, leukoerythroblastosis, extramedullary hematopoiesis[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] Erythrocytes fractionated by centrifugation revealed increased glycolytic enzyme activities of hexokinase, G3PD, PGK, TPI, PK, LDH, G6PD, and 6PGD in the reticulocyte-rich[pediatrics.aappublications.org] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com]

  • Gaucher Disease

    CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] Although Gaucher disease generally presents with massive splenomegaly, which one of the predisposing causes of a wandering spleen, literature shows only one report of a wandering[ncbi.nlm.nih.gov] Here we present a 36 year old male patient presenting with hip pain showing bilateral avascular necrosis of femoral head with massive splenomegaly and on evaluation, showed[ncbi.nlm.nih.gov]

  • Hypersplenism

    CONCLUSION: Our results demonstrate that shunt surgery with partial resection of the spleen is effective and safe for pediatric patients with massive splenomegaly and severe[ncbi.nlm.nih.gov] Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors[5minuteconsult.com] Apart from a strongly positive Mantoux test, all investigations for massive splenomegaly proved negative.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly.[ncbi.nlm.nih.gov] Here, we report a case of aCMLin a 5-month baby who presented with massive splenomegaly. The diagnosis was in accordance with the WHO criteria established in 2008.[ncbi.nlm.nih.gov] Massive splenomegaly is characteristic and may cause left hypochondral pain.[gpnotebook.co.uk]

  • Malaria

    After many bouts, the spleen may become fibrotic and firm or, in some patients, becomes massively enlarged (tropical splenomegaly).[msdmanuals.com] Splenomegaly may decrease with recurrent attacks of malaria as functional immunity develops.[msdmanuals.com]

  • Hodgkin's Disease

    The aetiology of multiple sclerosis (MS) is still an unresolved question. Several recently reported studies are implicating Epstein-Barr virus (EBV) as one of the key players in MS pathogenesis. We present a 21-year-old male patient with a history of EBV-related infectious mononucleosis in puberty and Hodgkin's[…][ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    Haematologica. 2017 Aug;102(8):1361-1367. doi: 10.3324/haematol.2017.167080. Epub 2017 May 18. Gullaksen SE 1 , Skavland J 1 , Gavasso S 2, 3 , Tosevski V 4 , Warzocha K 5 , Dumrese C 6 , Ferrant A 7 , Gedde-Dahl T 8 , Hellmann A 9 , Janssen J 10 , Labar B 11 , Lang A 12 , Majeed W 13 , Mihaylov G 14 , Stentoft J 15 ,[…][ncbi.nlm.nih.gov]

  • Congenital Hemolytic Anemia

    Children with massive splenomegaly had similar outcomes compared with children without massive splenomegaly.[ncbi.nlm.nih.gov] As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced.[orpha.net] Laboratory studies show evidence not only of many spherocytes but also increased numbers of reticulocytes (young red blood cells), hyperbilirubinemia (increased blood levels[medicinenet.com]

  • Leukoerythroblastic Anemia

    Massive splenomegaly can cause abdominal pressure, early satiety, cachexia, portal hypertension, and left upper quadrant abdominal pain; hepatomegaly may be present.[merckmanuals.com] An increased absolute number of reticulocytes indicates increased marrow erythropoiesis. u. Rouleaux: red cells in stacks, as coins.[kerrybrandis.com] […] chronic idiopathic myelofibrosis A chronic progressive condition characterised by panmyelosis and variable marrow fibrosis, massive splenomegaly secondary to extramedullary[medical-dictionary.thefreedictionary.com]

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