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109 Possible Causes for Mean Age at Onset 22 Years, Vacuolization

  • Oculo-Pharyngo-Distal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] RESULTS: The mean age at onset was around 22 years.[ncbi.nlm.nih.gov] Systemic Features: The mean age of onset of this progressive disease is 22 years. Pharyngeal and distal limb muscles seem to be primarily involved.[disorders.eyes.arizona.edu]

  • Oculopharyngeal Muscular Dystrophy

    In contrast, patients with distal myopathy with rimmed vacuoles revealed many rimmed vacuoles, on average in 20% of the fibers, and their oculopharyngeal muscles were spared[ncbi.nlm.nih.gov] Age: 6 to 50 years; Mean 22 years Ptosis Clinical General: Recessive vs Dominant forms Recessive form more severe Both forms with similar patterns of weakness Eyes Ptosis[neuromuscular.wustl.edu] Innervated cultures had large cytoplasmic vacuoles in a number of muscle fibers.[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy

    […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[ncbi.nlm.nih.gov] The age of onset ranged from two to 13 years, mean 7,5 years. Onset in the first decade was seen in 90%.[scielo.br] Our case suggests that posterior-dominant lower limb muscle impairment with gluteus and truncal muscle involvement and the detection of rimmed vacuoles on a muscle biopsy[ncbi.nlm.nih.gov]

  • Aspartylglucosaminuria

    Three years after BMT, no cells with storage vacuoles were present. Allogeneic BMT slowly normalises the pathological, biochemical and MRI findings in patients with AGU.[ncbi.nlm.nih.gov] The mean age of these six carriers at onset of joint symptoms was 31 years (range 22–50), whereas that of the 167 non-carriers was 39 years (range 16–77); the difference was[ard.bmj.com] The observation of vacuolated lymphocytes in a coarsely featured two year old female with hepatosplenomegaly, mitral insufficiency, and mild psychomotor retardation led to[ncbi.nlm.nih.gov]

  • Puerperium

    AF macrophages of fetal origin invade the maternal uterus near term. ( A ) AF macrophages are fetal in origin. β-gal staining was detected in cytoplasmic vacuoles of macrophages[ncbi.nlm.nih.gov] The mean age of the 10 cases that were analyzed was 31.6 years (range: 22-39 years). Five patients were over 35 years of age.[ncbi.nlm.nih.gov] The mean onset time of PST in puerperium was 10.3 days (5-17 days) after the delivery or cesarean.[ncbi.nlm.nih.gov]

  • Alzheimer Disease

    E, Other cells displayed, in addition to the chromatin segmentation, cytoplasmic distention and vacuolization. Scale bar, 10 μm.[doi.org] Were included 41 patients (22 M;19 F) with age at onset of 69 years (51-81) and a mean of 14.6 months (2-43) since diagnosis.[ncbi.nlm.nih.gov] Neuroprotective concentrations of the NMDA open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block[doi.org]

  • Sepsis

    Intracellular staphylococci are sometimes present within vacuoles, but the majority appear to be free and replicating within the cytoplasm, having escaped from the endosome[doi.org] Black men had the highest rate of sepsis during the study period (330.9 cases per 100,000), the youngest age at onset (mean age, 47.4 years), and the highest mortality (23.3[doi.org] Incidence During the 22-year study period, there were 10,319,418 reported cases of sepsis (accounting for 1.3 percent of all hospitalizations).[doi.org]

  • Pityriasis Lichenoides

    Histopathologically, basal cell vacuolation and perivascular infiltrate were seen in all the cases. Exocytosis was seen in 45.1% of the cases.[ncbi.nlm.nih.gov] Studies of children have shown a variable age of onset from 3-15 years, with a mean age of 9.3 years.[emedicine.com] Histologic Features: Parakeratotic scale, rare necrotic keratinocytes, mild basal vacuolization (changes less pronounced than in PLEVA) Upper dermal perivascular lymphocytic[dermpedia.org]

  • Chronic Fatigue Syndrome

    Histological and electron-microscopic studies revealed vacuolated cells with distorted nuclei and various cytoplasmic inclusions suggestive of incomplete viral expression.[ncbi.nlm.nih.gov] The proportion of males was 22% among cases and controls ( Table 2 ). Mean age at illness onset was 35.5 10.1 years.[mbio.asm.org]

  • Vitiligo

    […] findings include the following: Degenerative changes in keratinocytes and melanocytes in the border lesions and adjacent skin Increased numbers of Langerhans cells Epidermal vacuolization[emedicine.com] , and the average age of onset is somewhat variable in different geographic regions. 10 The mean age ranging from 22 years in the U.S. and India, 24 in Brazil and 25 years[dx.doi.org] Furthermore, differences in the mean age of onset have been reported among cases of sporadic and familial vitiligo. 11 - 13 The prevalence of vitiligo has been estimated between[dx.doi.org]

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