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57 Possible Causes for Mean Corpuscular Hemoglobin Concentration Increased

  • Vitamin B12 Deficiency

    Folate deficiency in the periconceptional period contributes to neural tube defects; deficits in vitamin B12 (cobalamin) have negative consequences on the developing brain during infancy; and deficits of both vitamins are associated with a greater risk of depression during adulthood. This review examines two[…][ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    In case 1, laboratory test results were as follows: hemoglobin 81.40 g/l, mean corpuscular hemoglobin concentration 339.00 g/l, mean corpuscular volume 82.88 fl, reticulocyte[ncbi.nlm.nih.gov] The mean corpuscular hemoglobin concentration (MCHC) is increased. Reticulocytosis of 15 to 30% and leukocytosis are common.[merckmanuals.com] Lab Studies Complete blood cell count Minimal to mild to moderate anemia Mean corpuscular hemoglobin concentration (MCHC) An increased MCHC is a characteristic feature of[medcaretips.com]

  • Autoimmune Hemolytic Anemia

    Average size of RBCs (mean corpuscular volume, MCV)—decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean[labtestsonline.org] corpuscular hemoglobin concentration, MCHC)—decreased Increased variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller[labtestsonline.org]

  • Folic Acid Deficiency

    Abstract On the suspicion that folate deficiency was not being thoroughly investigated we conducted a retrospective study of management in a teaching hospital. Notes from 84 consecutive patients with low red cell folates (mean age 69.5 years, range 21–95, M:F 33:51) were reviewed for haemoglobin, mean cell volume,[…][doi.org]

  • Sickle Cell Disease

    Sickle cell disease (SCD) usually manifests early in childhood. For the first 6 months of life, infants are protected largely by elevated levels of Hb F; soon thereafter, the condition becomes evident. The most common clinical manifestation of SCD is vaso-occlusive crisis. A vaso-occlusive crisis occurs when the[…][emedicine.medscape.com]

  • Hemoglobin C Disease

    Differences from normal cells are exaggerated if mean corpuscular hemoglobin concentration (MCHC) is increased, by suspension in hypertonic salt solution.[ncbi.nlm.nih.gov] mean corpuscular hemoglobin concentration (MCHC) of CC cells, which leads to intracellular crystallization of HbC. 15-17 Although AC individuals do not show these changes[doi.org] […] hemolytic anemia with frequent splenomegaly and abnormal blood smears containing microspherocytes and target cells. 14 A pathogenetic correlate of these findings is the increased[doi.org]

  • Iron Deficiency

    Eventually, the hemoglobin concentration and hematocrit fall.[cancertherapyadvisor.com] Automated hematology analyzers detect decreases in the mean corpuscular volume and, in some instruments, increases in the proportion of hypochromic cells.[cancertherapyadvisor.com] In the peripheral blood smear, experienced observers can detect the appearance of hypochromic, microcytic erythrocytes whose proportion increases with the duration and severity[cancertherapyadvisor.com]

  • Dehydrated Hereditary Stomatocytosis

    mean corpuscular hemoglobin concentration ; Increased red cell hemolysis by shear stress ; Increased serum ferritin ; Jaundice ; Pallor ; Reticulocytosis ; Splenomegaly Associated[mousephenotype.org] mean corpuscular hemoglobin concentration, decreased osmotic fragility, increased permeability to the univalent cations Na and K , and an increased proportion of phosphatidylcholine[ncbi.nlm.nih.gov] DHS patients typically exhibit mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic[uniprot.org]

  • Pernicious Anemia

    Average size of RBCs (mean corpuscular volume, MCV)—decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean[labtestsonline.org] corpuscular hemoglobin concentration, MCHC)—decreased Increased variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller[labtestsonline.org]

  • Microcytic Anemia

    corpuscular hemoglobin concentration (MCHC) Normal to markedly hypochromic Normochromic Normochromic to slightly hypochromic Red cell distribution width (RDW) * SIightly[web.archive.org] […] to moderate anemia Normal to slight anemia Mean corpuscular volume (MCV) Slightly to markedly microcytic Normocytic to slightly microcytic Normal to slightly microcytic Mean[web.archive.org] […] to moderately increased Normal to slightly decreased Normal to slightly increased Reticulocytes Decreased to increased Decreased Decreased Serum iron Slight to marked hypoferremia[web.archive.org]

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