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53 Possible Causes for Mean Corpuscular Volume Increased, Red Blood Cell Distribution Width Increased

  • Vitamin B12 Deficiency

    Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe[ncbi.nlm.nih.gov] Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[orpha.net] corpuscular volume, MCV).[jeffreydachmd.com]

  • Megaloblastic Anemia

    […] variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis[labtestsonline.org] Physicians caring for patients who receive low-dose methotrexate should be aware that an increase in the erythrocyte mean corpuscular volume may be a useful indicator of folate[ncbi.nlm.nih.gov] Treatment with sunitinib may increase the mean corpuscular volume and suggested the hypothesis that this increase is related to the metabolism of vitamin B 12 or folate.[omicsonline.org]

  • Myelodysplasia

    Good's syndrome, also known as thymoma with combined immunodeficiency, is rare. The immunodeficiency may precede, arise concurrently with or follow the diagnosis of thymoma. In addition to myasthenia gravis and Good's syndrome, paraneoplastic syndromes associated with thymoma can also be manifested with hematological[…][ncbi.nlm.nih.gov]

  • Folate-Deficiency Anemia

    The mean corpuscular volume is typically increased (above 96 fL ).[symptoma.com] Folate Deficiency causes a specific type of Anemia called Macrocytic/Megaloblstic Anemia where the size (Mean Corpuscular Volume) of the red blood cells increased .[stomponstep1.com] In a recent study, 7 percent of patients had a mean corpuscular volume greater than 96 fL, and 1.7 percent had a mean corpuscular volume greater than 100 fL. 2 With the advent[aafp.org]

  • Iron Deficiency

    Average size of RBCs (MCV) — may be decreased Average amount of Hb in RBCs (MCH) — may be decreased Increased variation in the size of RBCs (red cell distribution width (RDW[labtestsonline.org.au] Subsequently, the mean corpuscular volume (MCV) increased as iron was mobilized from body stores and reticulocytosis occurred.[emedicine.com] )) A blood film may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis) and shape (poikilocytosis).[labtestsonline.org.au]

  • Iron Deficiency Anemia

    […] high red blood cell distribution width, reflecting an increased variability in the size of red blood cells.A low mean corpuscular volume also appears during the course of[en.wikipedia.org] IV iron sucrose resulted in a statistically significant and clinically meaningful increase in hemoglobin, mean corpuscular volume, serum iron, ferritin, and % iron saturation[ncbi.nlm.nih.gov] Subsequently, the mean corpuscular volume (MCV) increased as iron was mobilized from body stores and reticulocytosis occurred.[emedicine.medscape.com]

  • Pernicious Anemia

    […] variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis[labtestsonline.org] Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[orpha.net] […] in mean corpuscular volume and levels of ferritin and gastrin, and a decrease in vitamin B 12 levels.[doi.org]

  • Leukoerythroblastic Anemia

    Reflected in increased RDW (Red cell Distribution Width) b. Band cell: the stage of neutrophil maturation immediately before full maturity.[kerrybrandis.com] mean corpuscular volume (macrocytic anemia: MCV 100 fL) Ethanol abuse Folate deficiency Vitamin B12 deficiency Myelodysplastic syndromes Acute myeloid leukemias (eg, erythroleukemia[timeofcare.com] Glossary of Useful Blood Count Descriptors (see website for atlas) a. Anisocytosis: red cells of unequal size.[kerrybrandis.com]

  • Aplastic Anemia

    […] variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis[labtestsonline.org] Mean Corpuscular Volume ( MCV ) measures the average size of red blood cells. It is high when red blood cells are larger than normal.[aamds.org] […] decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean corpuscular hemoglobin concentration, MCHC)—decreased Increased[labtestsonline.org]

  • Vitamin B12 Deficiency Anemia

    red blood cell distribution width (RDW).[clinicaladvisor.com] mean corpuscular volume (MCV 100 fL) and mean corpuscular hemoglobin (MCH) Reticulocyte count is decreased due to destruction of fragile and abnormal megaloblastic erythroid[pathologyoutlines.com] Macrocytosis (MCV 100 fL) may be masked or absent in the presence of concomitant iron deficiency or alpha/beta thal traits, although these cases tend to have an increased[clinicaladvisor.com]

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