Dermal fibers like collagen are responsible for the mechanical resistance of the skin. Accordingly, damage to these fibers, as observed in connective tissue disorders, may give rise to mechanically fragile skin.
Most common diseases
Porphyria Cutanea Tarda
The initial clinical presentation commonly includes mechanical fragility of the skin and blisters in sun-exposed areas. [ncbi.nlm.nih.gov]
fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]
fragility erosions and thickened skin blisters with painful indolent sores as shown [Figure 1], [Figure 2] and [Figure 3] and hypertrichosis on face. [ijhas.in]
Rosacea
Fragility of the epidermis, a common pathophysiological mechanism of acne vulgaris, rosacea and reactive skin involving inflammasome activation. [scielo.br]
Epidermolysis Bullosa Simplex
It is characterized by mechanically fragile skin that readily blister. [genome.jp]
Epidermolysis bullosa (EB) simplex, like all types of inherited epidermolysis bullosa, is characterized by the presence of mechanically fragile skin and recurrent blisters [clinicaladvisor.com]
Alpha-B Crystallinopathy
It is characterized by mechanically fragile skin that readily blister ... [kegg.jp]
fragile skin that readily blister. [kegg.jp]
Congenital malformation H00586 Epidermolysis bullosa, junctional Inherited epidermolysis bullosa is a diverse group of disorders characterized by mechanically fragile skin [kegg.jp]
Epididymitis
EB is a group of severe and socially relevant genetic skin diseases characterized by mechanically induced blistering and life-long fragility of the skin. [ojrd.biomedcentral.com]
The Epidermolysis bullosa (EB) Center Freiburg is the coordination center of the German EB-Network and a national center of excellence for rare skin fragility disorders. [ojrd.biomedcentral.com]
It combines clinical activities with internationally competitive research and deals with molecular diagnostics, clinical management, elucidation of disease mechanisms, and [ojrd.biomedcentral.com]
Skin Cancer
RDEB‐HS is characterised by repeated blister formation, leading to mechanical fragility of the skin. It can affect all tissues with an epithelial surface or lining. [doi.org]
Collagen VII forms anchoring fibrils, crucial structures that "sew" the outer skin (epidermis) onto the inner skin (dermis). [doi.org]
Squamous Cell Carcinoma of the Skin
Hereditary Renal Cell Carcinoma
EB is a group of severe and socially relevant genetic skin diseases characterized by mechanically induced blistering and life-long fragility of the skin. [ojrd.biomedcentral.com]
The Epidermolysis bullosa (EB) Center Freiburg is the coordination center of the German EB-Network and a national center of excellence for rare skin fragility disorders. [ojrd.biomedcentral.com]
It combines clinical activities with internationally competitive research and deals with molecular diagnostics, clinical management, elucidation of disease mechanisms, and [ojrd.biomedcentral.com]
Epilepsy
EB is a group of severe and socially relevant genetic skin diseases characterized by mechanically induced blistering and life-long fragility of the skin. [ojrd.biomedcentral.com]
The Epidermolysis bullosa (EB) Center Freiburg is the coordination center of the German EB-Network and a national center of excellence for rare skin fragility disorders. [ojrd.biomedcentral.com]
It combines clinical activities with internationally competitive research and deals with molecular diagnostics, clinical management, elucidation of disease mechanisms, and [ojrd.biomedcentral.com]
Junctional Epidermolysis Bullosa
Key historical features The diagnosis of inherited junctional epidermolysis bullosa (EB) should be considered in any newborn or child with mechanically fragile skin and blisters [dermatologyadvisor.com]
The phenotypic consequences are diminished dermal-epidermal adhesion and, as clinical symptoms, skin fragility and mechanically induced blistering. [ncbi.nlm.nih.gov]
Any of the above mutations will result in mechanically fragile skin, characterized by blister formation within the same ultrastructural level (i.e. intra-lamina lucida) in [dermatologyadvisor.com]