Mechanically-fragile-skin: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for mechanically fragile skin

Porphyria Cutanea Tarda

The initial clinical presentation commonly includes mechanical fragility of the skin and blisters in sun-exposed areas. [ncbi.nlm.nih.gov]

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

fragility erosions and thickened skin blisters with painful indolent sores as shown [Figure 1], [Figure 2] and [Figure 3] and hypertrichosis on face. [ijhas.in]

Rosacea

Fragility of the epidermis, a common pathophysiological mechanism of acne vulgaris, rosacea and reactive skin involving inflammasome activation. [scielo.br]

Epidermolysis Bullosa Simplex

It is characterized by mechanically fragile skin that readily blister. [genome.jp]

Epidermolysis bullosa (EB) simplex, like all types of inherited epidermolysis bullosa, is characterized by the presence of mechanically fragile skin and recurrent blisters [dermatologyadvisor.com]

Alpha-B Crystallinopathy

It is characterized by mechanically fragile skin that readily blister ... [kegg.jp]

fragile skin that readily blister. [kegg.jp]

Congenital malformation H00586 Epidermolysis bullosa, junctional Inherited epidermolysis bullosa is a diverse group of disorders characterized by mechanically fragile skin [kegg.jp]

Epididymitis

EB is a group of severe and socially relevant genetic skin diseases characterized by mechanically induced blistering and life-long fragility of the skin. [ojrd.biomedcentral.com]

The Epidermolysis bullosa (EB) Center Freiburg is the coordination center of the German EB-Network and a national center of excellence for rare skin fragility disorders. [ojrd.biomedcentral.com]

It combines clinical activities with internationally competitive research and deals with molecular diagnostics, clinical management, elucidation of disease mechanisms, and [ojrd.biomedcentral.com]

Hereditary Renal Cell Carcinoma

EB is a group of severe and socially relevant genetic skin diseases characterized by mechanically induced blistering and life-long fragility of the skin. [ojrd.biomedcentral.com]

The Epidermolysis bullosa (EB) Center Freiburg is the coordination center of the German EB-Network and a national center of excellence for rare skin fragility disorders. [ojrd.biomedcentral.com]

It combines clinical activities with internationally competitive research and deals with molecular diagnostics, clinical management, elucidation of disease mechanisms, and [ojrd.biomedcentral.com]

Malignant Neoplasm of the Skin

RDEB‐HS is characterised by repeated blister formation, leading to mechanical fragility of the skin. It can affect all tissues with an epithelial surface or lining. [doi.org]

Collagen VII forms anchoring fibrils, crucial structures that "sew" the outer skin (epidermis) onto the inner skin (dermis). [doi.org]

Squamous Cell Carcinoma of the Skin

fragile skin, have a 50 times greater than normal risk of developing SCC. [doi.org]

[…] dystrophic epidermolysis bullosa (RDEB), in which there is a defect in the type VII collagen gene whereby either no collagen VII or very low levels are produced resulting in a mechanically [doi.org]

Epilepsy

EB is a group of severe and socially relevant genetic skin diseases characterized by mechanically induced blistering and life-long fragility of the skin. [ojrd.biomedcentral.com]

The Epidermolysis bullosa (EB) Center Freiburg is the coordination center of the German EB-Network and a national center of excellence for rare skin fragility disorders. [ojrd.biomedcentral.com]

It combines clinical activities with internationally competitive research and deals with molecular diagnostics, clinical management, elucidation of disease mechanisms, and [ojrd.biomedcentral.com]

Platelet-Type Bleeding Disorder 19

It is characterized by mechanically fragile skin that readily ... [kegg.jp]

Junctional Epidermolysis Bullosa

Key historical features The diagnosis of inherited junctional epidermolysis bullosa (EB) should be considered in any newborn or child with mechanically fragile skin and blisters [dermatologyadvisor.com]

The phenotypic consequences are diminished dermal-epidermal adhesion and, as clinical symptoms, skin fragility and mechanically induced blistering. [ncbi.nlm.nih.gov]

Any of the above mutations will result in mechanically fragile skin, characterized by blister formation within the same ultrastructural level (i.e. intra-lamina lucida) in [dermatologyadvisor.com]

Appendiceal Abscess

[…] junctional, or dermal components underlying the physiologic mechanical properties of the skin. [emedicine.medscape.com]

Epidermolysis bullosa The term epidermolysis bullosa indicates a group of congenital disorders characterized by skin fragility due to an inherited defect in the epidermal, [emedicine.medscape.com]

Drug Eruptions

The mechanisms include increased fragility of the capillaries, allergic thrombocytopenia, and capillaritis. [news-medical.net]

[…] count 9 /l) Capillary fragility due to systemic, inhaled or topical corticosteroids Capillaritis (unknown mechanism) Overdose of anticoagulants often because of drug interaction [health.auckland.ac.nz]

Purpuric rashes: These are caused by bleeding into the skin, in reaction to drugs such as medications that prevent the formation of platelets. [news-medical.net]

Epidermolysis Bullosa

The main clinical features are mechanical fragile skin, tension blisters and encrustation. [zgmfskin.net]

Epidermolysis bullosa (EB) is a heterogeneous group of rare, chronic, inherited skin disorders characterized by marked mechanical fragility of epithelial tissues, with blistering [ncbi.nlm.nih.gov]

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

Vulvar Hemangioma

[…] junctional, or dermal components underlying the physiologic mechanical properties of the skin. [emedicine.medscape.com]

Lupus Erythematosus

Furthermore, mechanical skin fragility is not a common feature of BSLE, though it is a feature of EBA. [mdedge.com]

Dystrophic Epidermolysis Bullosa

In each situation, the end result is marked mechanical fragility of the skin, recurrent blister formation, and scarring. [dermatologyadvisor.com]

Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in the gene encoding type VII collagen, resulting in fragile skin and mucous membranes that [ncbi.nlm.nih.gov]

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

Sialolithiasis

This condition is characterized by a spectrum of blistering and mechanical fragility of the skin. [ncbi.nlm.nih.gov]

Acute Hepatic Porphyria

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

(painless blisters, skin fragility, sclerodermatous changes, cheeks and temples, hypertrichosis) 1. [aasldpubs.onlinelibrary.wiley.com]

[…] porphyria variega ta ( variegate porphyria (VP)) a hereditary, autosomal dominant, type of hepatic porphyria characterized by chronic cutaneous manifestations, notably extreme mechanical [medical-dictionary.thefreedictionary.com]

Muscular Dystrophy-Dystroglycanopathy Type C5

[…] disorder characterized by mechanical fragility of the skin, resulting in blistering and chronic wounds. [paperity.org]

TGFβ-signaling in Squamous Cell Carcinoma Occurring in Recessive Dystrophic Epidermolysis Bullosa Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary skin [paperity.org]

Limb-Girdle Muscular Dystrophy Type 2L

[…] disorder characterized by mechanical fragility of the skin, resulting in blistering and chronic wounds. [paperity.org]

TGFβ-signaling in Squamous Cell Carcinoma Occurring in Recessive Dystrophic Epidermolysis Bullosa Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary skin [paperity.org]

Acute Intermittent Porphyria

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

Epidermolysis Bullosa Simplex Type Kobner

It is characterized by mechanically fragile skin that readily blister. [genome.jp]

[…] microfilaments in the skin, resulting in skin that is fragile and sensitive to mechanical pressure or friction. [nature.com]

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

Variegate Porphyria

Variegate porphyria (VP) is an autosomal dominant disease characterized in adults by mechanical fragility and blistering of sun-exposed skin or acute visceral and neurological [ncbi.nlm.nih.gov]

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

The most common photocutaneous manifestations of porphyria cutanea tarda are due to increased mechanical fragility after sunlight exposure; erosions and blisters form painful [emedicine.medscape.com]

Impetigo Neonatorum

Mechanical fragility at birth is the hallmark of the disease characterized by extensive blistering of the skin associated with crusting and erosions. [indianpediatrics.net]

Hepatoerythropoietic Porphyria

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

What you should be alert for in the history Mechanical fragility and blistering of sunlight-exposed skin, typically appearing for the first time during spring or summer, are [clinicalpainadvisor.com]

Congenital Erythropoietic Porphyria

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

The interaction of excess porphyrins in the skin and light radiation causes photoxidative damage of biomolecular targets that is manifested as mechanical fragility and blistering [emedicine.medscape.com]

Epidermolysis Bullosa Simplex Type Cockayne-Touraine

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

Epidermolysis bullosa simplex (EBS) is characterized by fragility of the skin (and mucosal epithelia in some cases) that results in non-scarring blisters and erosions caused [ncbi.nlm.nih.gov]

EB comprises a group of rare genetic states that are characterized by extremely fragile skin and recurrent blister formation following minor mechanical friction or trauma. [clinicaladvisor.com]

Vulvar Dystrophy

[…] junctional, or dermal components underlying the physiologic mechanical properties of the skin. [emedicine.medscape.com]

Transient Bullous Dermolysis of the Newborn

These findings support the hypothesis that the temporary mechanical fragility and blistering of the skin in infants with this rare subset of dominant dystrophic epidermolysis [uncch.pure.elsevier.com]

Diagnostic Approach Physical findings The diagnosis of EB is suggested at birth or during early infancy by the presence of mechanical fragility of the skin, recurrent blisters [online.epocrates.com]

This Consensus meeting resulted in an expansion of EB’s classification to include other disorders associated with mechanical fragility of the skin. [debra.org]