Mechanically Fragile Skin: Causes & Reasons

Possible Causes for Mechanically Fragile Skin

The initial clinical presentation commonly includes mechanical fragility of the skin and blisters in sun-exposed areas. [ncbi.nlm.nih.gov]

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

fragility erosions and thickened skin blisters with painful indolent sores as shown [Figure 1], [Figure 2] and [Figure 3] and hypertrichosis on face. [ijhas.in]

Chester Porphyria

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

[…] porphyria variega´ta (variegate porphyria (VP)) a hereditary, autosomal dominant, type of hepatic porphyria characterized by chronic cutaneous manifestations, notably extreme mechanical [medical-dictionary.thefreedictionary.com]

Epidermolysis Bullosa Simplex

It is characterized by mechanically fragile skin that readily blister. [genome.jp]

Epidermolysis bullosa (EB) simplex, like all types of inherited epidermolysis bullosa, is characterized by the presence of mechanically fragile skin and recurrent blisters [dermatologyadvisor.com]

Autosomal Recessive Epidermolysis Bullosa Simplex

[…] by blistering of the skin and mucosae following mild mechanical trauma. [pcds.org.uk]

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

Format Definition A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering and cleavage within basal keratinocytes, fragility of the skin and [uniprot.org]

Epidermolysis Bullosa Simplex Type Kobner

It is characterized by mechanically fragile skin that readily blister. [genome.jp]

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

[…] microfilaments in the skin, resulting in skin that is fragile and sensitive to mechanical pressure or friction. [nature.com]

Platelet-Type Bleeding Disorder 19

It is characterized by mechanically fragile skin that readily ... [kegg.jp]

Generalized Dominant Dystrophic Epidermolysis bullosa

[…] by blistering of the skin and mucosae following mild mechanical trauma. [pcds.org.uk]

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

fragility disorders characterized by blistering of the skin and mucosae following mild mechanical trauma. [ijpd.in]

Epidermolysis Bullosa Simplex Type Cockayne-Touraine

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

EB comprises a group of rare genetic states that are characterized by extremely fragile skin and recurrent blister formation following minor mechanical friction or trauma. [clinicaladvisor.com]

Dst-null mice show neural degeneration and mild skin fragility upon mechanical stress 18 Epidermolysis bullosa simplex. Target proteins in suprabasal EBS 4.1. [slideplayer.com]

Epidermolysis Bullosa

The main clinical features are mechanical fragile skin, tension blisters and encrustation. [zgmfskin.net]

Epidermolysis bullosa (EB) is a heterogeneous group of rare, chronic, inherited skin disorders characterized by marked mechanical fragility of epithelial tissues, with blistering [ncbi.nlm.nih.gov]

EB is a group of severe and socially relevant genetic skin diseases characterized by mechanically induced blistering and life-long fragility of the skin. [ojrd.biomedcentral.com]

Adult Junctional Epidermolysis Bullosa

[…] by blistering of the skin and mucosae following mild mechanical trauma. [pcds.org.uk]

Key historical features The diagnosis of inherited junctional epidermolysis bullosa (EB) should be considered in any newborn or child with mechanically fragile skin and blisters [dermatologyadvisor.com]

Created: 28th September 2014 | Last Updated: 31st May 2018 Introduction Epidermolysis bullosa (EB) comprises a group of genetically determined skin fragility conditions characterised [pcds.org.uk]

Transient Bullous Dermolysis of the Newborn

These findings support the hypothesis that the temporary mechanical fragility and blistering of the skin in infants with this rare subset of dominant dystrophic epidermolysis [uncch.pure.elsevier.com]

Diagnostic Approach Physical findings The diagnosis of EB is suggested at birth or during early infancy by the presence of mechanical fragility of the skin, recurrent blisters [online.epocrates.com]

This Consensus meeting resulted in an expansion of EB’s classification to include other disorders associated with mechanical fragility of the skin. [debra.org]

Alpha-B Crystallinopathy

It is characterized by mechanically fragile skin that readily blister ... [kegg.jp]

fragile skin that readily blister. [kegg.jp]

Congenital malformation H00586 Epidermolysis bullosa, junctional Inherited epidermolysis bullosa is a diverse group of disorders characterized by mechanically fragile skin [kegg.jp]

Junctional Epidermolysis Bullosa

The phenotypic consequences are diminished dermal-epidermal adhesion and, as clinical symptoms, skin fragility and mechanically induced blistering. [ncbi.nlm.nih.gov]

Any of the above mutations will result in mechanically fragile skin, characterized by blister formation within the same ultrastructural level (i.e. intra-lamina lucida) in [dermatologyadvisor.com]

Hereditary Renal Cell Carcinoma

EB is a group of severe and socially relevant genetic skin diseases characterized by mechanically induced blistering and life-long fragility of the skin. [ojrd.biomedcentral.com]

The Epidermolysis bullosa (EB) Center Freiburg is the coordination center of the German EB-Network and a national center of excellence for rare skin fragility disorders. [ojrd.biomedcentral.com]

It combines clinical activities with internationally competitive research and deals with molecular diagnostics, clinical management, elucidation of disease mechanisms, and [ojrd.biomedcentral.com]

Dystrophic Epidermolysis Bullosa

In each situation, the end result is marked mechanical fragility of the skin, recurrent blister formation, and scarring. [dermatologyadvisor.com]

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in the gene encoding type VII collagen, resulting in fragile skin and mucous membranes that [ncbi.nlm.nih.gov]

Epidermolysis Bullosa - Pyloric Atresia

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

DEFINITION• Group of genetically determined skin fragility disorders characterised by blistering of skin and mucosae following mild mechanical trauma.• Alternative term – [slideshare.net]

Limb-Girdle Muscular Dystrophy Type 2L

[…] disorder characterized by mechanical fragility of the skin, resulting in blistering and chronic wounds. [paperity.org]

TGFβ-signaling in Squamous Cell Carcinoma Occurring in Recessive Dystrophic Epidermolysis Bullosa Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary skin [paperity.org]

Muscular Dystrophy-Dystroglycanopathy Type C5

[…] disorder characterized by mechanical fragility of the skin, resulting in blistering and chronic wounds. [paperity.org]

TGFβ-signaling in Squamous Cell Carcinoma Occurring in Recessive Dystrophic Epidermolysis Bullosa Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary skin [paperity.org]

Herlitz Disease

An overview of JEB Epidermolysis bullosa (EB) is a family of rare, inherited disorders characterized by fragility of the skin and mucous membranes in response to minor mechanical [nature.com]

Pretibial Dystrophic Epidermolysis Bullosa

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

Clinical description General considerations [ 2 ] The hallmark cutaneous features of inherited EB, in addition to mechanically fragile skin and easy inducibility of blisters [ojrd.biomedcentral.com]

Purpura Senilis

This purpura occurs when the protein in the skin degrades leading to fragile skin and thus damage to the tiny blood vessels under the skin. [godoymedical.net]

With modern increases in lifespan, skin atrophy associated with solar damage is presenting as a clinically significant inability to mechanically protect patients. [pubmed.ncbi.nlm.nih.gov]

Dermatoporosis: a chronic cutaneous insufficiency/fragility syndrome. Clinicopathological features, mechanisms, prevention and potential treatments. [ncbi.nlm.nih.gov]

Variegate Porphyria

Variegate porphyria (VP) is an autosomal dominant disease characterized in adults by mechanical fragility and blistering of sun-exposed skin or acute visceral and neurological [ncbi.nlm.nih.gov]

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

The most common photocutaneous manifestations of porphyria cutanea tarda are due to increased mechanical fragility after sunlight exposure; erosions and blisters form painful [emedicine.medscape.com]

Sialolithiasis

This condition is characterized by a spectrum of blistering and mechanical fragility of the skin. [ncbi.nlm.nih.gov]

Epidermolysis Bullosa Pruriginosa

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [ojrd.biomedcentral.com]

DISCUSSION Epidermolysis bullosa (EB) is a hereditary mechanical bullous dermatosis characterized by the formation of blisters caused by skin fragility and mechanical trauma [wjgnet.com]

Hepatoerythropoietic Porphyria

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

What you should be alert for in the history Mechanical fragility and blistering of sunlight-exposed skin, typically appearing for the first time during spring or summer, are [clinicalpainadvisor.com]

Hallopeau-Siemens Disease

All types and subtypes of inherited EB are associated with mechanically fragile skin. This can be induced by light lateral or rotary traction to the skin. [link.springer.com]

In each situation, the end result is marked mechanical fragility of the skin, recurrent blister formation, and scarring. [dermatologyadvisor.com]

Perioperative careful management and minimal mandatory monitoring might be needed to minimize mechanical injury to the skin and mucous membranes. [omicsonline.org]

Congenital Erythropoietic Porphyria

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

The interaction of excess porphyrins in the skin and light radiation causes photoxidative damage of biomolecular targets that is manifested as mechanical fragility and blistering [emedicine.medscape.com]

[…] porphyria variega´ta ( variegate porphyria (VP)) a hereditary, autosomal dominant, type of hepatic porphyria characterized by chronic cutaneous manifestations, notably extreme mechanical [medical-dictionary.thefreedictionary.com]

Skeletal Dysplasia - Intellectual Disability Syndrome

It is characterized by mechanically fragile skin that readily ... [kegg.jp]

Delta Aminolevulinate Dehydrase Deficiency

fragility of the skin, particularly areas exposed to the sunlight, and by episodes of abdominal pain and neuropathy. [medical-dictionary.thefreedictionary.com]

(painless blisters, skin fragility, sclerodermatous changes, cheeks and temples, hypertrichosis) 1. [aasldpubs.onlinelibrary.wiley.com]

[…] porphyria variega´ta ( variegate porphyria (VP)) a hereditary, autosomal dominant, type of hepatic porphyria characterized by chronic cutaneous manifestations, notably extreme mechanical [medical-dictionary.thefreedictionary.com]

Cicatricial Alopecia

The initial clinical presentation commonly includes mechanical fragility of the skin and blisters in sun-exposed areas. [ncbi.nlm.nih.gov]

Porphyria cutanea tarda (PCT) is a disorder caused by deficient activity of a liver enzyme that leads to the accumulation of photoactive metabolites in the skin. [ncbi.nlm.nih.gov]