Median Cleft Lip: Causes & Reasons

Possible Causes for Median Cleft Lip

Median cleft lip associated with bimanual hexadactyly and bilateral accessory toes: another case. [jprasurg.com]

median cleft lip, cleft palate, palatal grooves, alveolar notching, hyperplastic oral frenula, lobulated/bifid tongue, tongue hamartomas, missing incisor teeth, supernumerary [accessanesthesiology.mhmedical.com]

Median cleft lip, polydactyly, syndactyly and toe anomalies in a non-Indian infant. British Journal of Plastic Surgery. 1983; 36: 447 Google Scholar Gopalakrishna A. [jprasurg.com]

Frontonasal Dysplasia

This represents a very rare disorder involving the face (hypertelorism, median cleft lip, absence of the nasal tip) and often the central nervous system (CNS) (cranium bifidum [ncbi.nlm.nih.gov]

No supernumerary teeth were observed; 65% of individuals exhibited occlusal alterations, especially anterior open bite in the two individuals with median cleft lip. [ncbi.nlm.nih.gov]

cleft lip; median cleft nose; and/or any abnormal development of the center (median cleft) of the face. [ncbi.nlm.nih.gov]

Mohr Syndrome

Mohr syndrome is an autosomal recessive inherited disease characterized by median cleft lip, poly lobed tongue, absence of medial incisors, and polydactyly of hands and feet [ncbi.nlm.nih.gov]

cleft lip, fatty hamartomas on the dorsum of the tongue, conductive hearing loss, and unilateral or bilateral renal agenesis. [ncbi.nlm.nih.gov]

OFD5: Autosomal recessive includes polydactyly and median cleft lip only. OFD6: Autosomal recessive distinguished by polydactyly and cerebellar malformations. [japi.org]

Melhem-Fahl Syndrome

cleft lip corpus callosum lipoma skin polyps Median nodule of the upper lip Mediastinal endodermal sinus tumors Mediterranean fever Medium-chain Acyl-CoA dehydrogenase deficiency [statemaster.com]

cleft lip corpus callosum lipoma skin polyps Median nodule of the upper lip Mediastinal endodermal sinus tumors Medrano Roldan syndrome Megalencephalic leukodystrophy Megalencephaly-cystic [en.wikipedia.org]

cleft lip corpus callosum lipoma skin polyps Median nodule of the upper lip Mediastinal endodermal sinus tumors Medium-chain Acyl-CoA dehydrogenase deficiency Medullary thyroid [mindmappedia.com]

Holoprosencephaly Sequence

Face with median cleft lip. Hypotelorism with a flattened or absent nose. Face with median philtrum-premaxilla a large and flat nose. [fetalultrasound.com]

The other had multiple facial abnormalities such as hypotelorism, median cleft lip and palate, and preauricular skin tag. [cjhr.org]

One case of median cleft lip with hypotelorism and two cases of cyclopia, all with brains exhibiting alobar holoprosencephaly, were examined by detailed anatomical dissection [ncbi.nlm.nih.gov]

Malignant Hyperthermia - Arthrogryposis - Torticollis

cleft lip corpus callosum lipoma skin polyps Median nodule of the upper lip Mediastinal endodermal sinus tumors Mediastinal syndrome Mediterranean fever Medium-chain Acyl-CoA [en.wikipedia.org]

Median cleft lip corpus callosum lipoma skin polyps[?] Median nodule of the upper lip[?] Mediastinal endodermal sinus tumors[?] Mediterranean fever[?] [encyclopedia.kids.net.au]

Familial Median Cleft of the Upper and Lower Lips

Incomplete median cleft of lower lip with ankyloglossia. [jclpca.org]

lip (disorder) Cleft lip and alveolus Cleft lip and alveolus (disorder) Familial median cleft of upper and lower lip Familial median cleft of upper and lower lip (disorder [medicbind.com]

Keywords Tessier cleft 30; Median cleft; Cervical teratoma; Ankyloglossia Introduction Cleft lip and palate are common, whereas median mandibular clefts are extremely rare [omicsonline.org]

Mononen-Karnes-Senac Syndrome

cleft lip corpus callosum lipoma skin polyps Median nodule of the upper lip Mediastinal endodermal sinus tumors Mediastinal syndrome Mediterranean fever Medium-chain Acyl-CoA [en.wikipedia.org]

Wide mouth

Group I – Pre alveolar clefts: • Unilateral cleft lip • Bilateral cleft lip • Median cleft lip Group II - Post alveolar clefts: • Cleft hard palate alone • Cleft soft palate [webdental.com]

(Left) Incomplete median lip cleft with moderate widening of the interorbital distance and nose. [passeidireto.com]

Median cleft of the lower lip and mandible: A case report. Br J Plast Surg. 1971;24:391–3. [PubMed] [Google Scholar] 4. Rosenthal R. [ncbi.nlm.nih.gov]

Arhinencephaly

Infant, Newborn Trisomy Pub Type(s) Journal Article Language eng PubMed ID 14079950 TY - JOUR T1 - FAMILIAL ALOBAR HOLOPROSENCEPHALY (ARHINENCEPHALY) WITH MEDIAN CLEFT LIP [unboundmedicine.com]

Median cleft lip 13. Unilateral cleft lip 14. Bilateral cleft lip 15. Absence of the superior labial frenulum 16. Solitary median central maxillar incisor [en.atlaseclamc.org]

[…] normality, extends through ethmocephaly, cebocephaly, median cleft lip, and the two patients presented here. [pediatrics.aappublications.org]

Isolated Arhinencephaly

Note the facial features which include median cleft lip, nasal depression, hypo- telorism, receding forehead, and microcephaly. A median cleft palate was also present. [rrnursingschool.biz]

cleft lip, closely set eyes, small flattened nose hypertelorism, microphtalmy, unilateral or bilateral cleft lip can be seen as well etiology: often is associated with these [atlases.muni.cz]

It is involved in large variable phenotypic expressivity, going of polymalformative syndrome to the isolated median cleft lip or palate [ 10 ]. [omicsonline.org]

Myelocerebellar Disorder

cleft lip corpus callosum lipoma skin polyps * Median nodule of the upper lip * Mediastinal endodermal sinus tumors * Mediterranean fever * Medium-chain Acyl-CoA dehydrogenase [en.academic.ru]

McPherson Robertson Cammarano syndrome Me Mea-Med Meacham Winn Culler syndrome Meadows syndrome Measles Meckel like syndrome Meckel syndrome Medeira Dennis Donnai syndrome Median [academickids.com]

Short Rib-Polydactyly Syndrome

The pregnancy was terminated, and a fetus was delivered with facial dysmorphism, a median cleft lip, a narrow chest, micromelia, aplasia of tibiae, hypoplastic nails, syndactyly [ncbi.nlm.nih.gov]

We present premature female twin fetuses with concordant extremely shortened ribs, short limbs, macrocephaly, median cleft upper lip and facial dysmorphism. [ncbi.nlm.nih.gov]

cleft lip and palate Central cleft lip and palate Midline cleft lip/palate [ more ] 0008501 Narrow chest Low chest circumference Narrow shoulders [ more ] 0000774 Natal tooth [rarediseases.info.nih.gov]

Saldino-Noonan Syndrome

Type IV (Beemer-Langer ): median cleft lip and ambiguous genitalia in some 46,XY individuals. [fetalmedicine.org]

cleft lip, preaxial and postaxial polysyndactyly, short ribs and limbs, genital abnormalities, and anomalies of epiglottis and viscera Short rib polydactyly syndrome type [emedicine.medscape.com]

A distinguishing feature of the syndrome is the presence of a median or midline cleft lip with or without cleft palate. [obgyn.mhmedical.com]

Cleft of Hard Palate

cheiloschisis congenital fissure of lip harelip labium leporinum Excludes: cleft lip with cleft palate ( Q37.- ) Q36.0 Cleft lip, bilateral Q36.1 Cleft lip, median Q36.9 [apps.who.int]

Q36.1 Cleft lip, median Q36.9 Cleft lip, unilateral Q37 Cleft palate with cleft lip Q37.0 Cleft hard palate with bilateral cleft lip Reimbursement claims with a date of service [icd10data.com]

lip alone type II: unilateral cleft lip and palate type III: bilateral cleft lip and palate type IV: midline/median cleft lip and palate type V: facial clefts associated [radiopaedia.org]

Thoracolaryngopelvic Dysplasia

cleft lip, preaxial and postaxial polysyndactyly, short ribs and limbs, genital abnormalities, and anomalies of epiglottis and viscera Short rib polydactyly syndrome type [emedicine.medscape.com]

The occurrence of a median cleft lip also identifies type 2 and type 4 SRPS. [journals.lww.com]

lip palate psychomotor retardation Polydactyly myopia syndrome Polydactyly postaxial dental and vertebral Polydactyly postaxial with median cleft of upper lip Polydactyly [sosu.us]

Prata-Libéral-Gonçalves Syndrome

lip palate psychomotor retardation Polydactyly myopia syndrome Polydactyly postaxial dental and vertebral Polydactyly postaxial with median cleft of upper lip Polydactyly [mindmappedia.com]

[…] disease, familial Polycystic ovarian syndrome Polycystic ovaries urethral sphincter dysfunction Polycythemia vera Polydactyly alopecia seborrheic dermatitis Polydactyly cleft [bioreference.net]

Polydactyly postaxial with median cleft of upper lip[?] Polydactyly postaxial[?] Polydactyly preaxial type 1[?] Polydactyly syndrome middle ray duplication[?] [encyclopedia.kids.net.au]

Aprosencephaly and Cerebellar Dysgenesis

[ 5 ] Anterior cephalocele Median cleft lip, hypertelorism Frontonasal dysplasia ACC, lipoma, macrocephaly, HME, cranium bifidum Sporadic, ALX AR mutations, AD, X-linked patterns [radiologykey.com]

Marilyn Jones ; Introduction ; 17.1 Median Cleft Lip ; 17.2 Cleft Lip with or without Cleft Palate ; 17.3 Cleft Palate ; Chapter 18 Tongue ; Michael I. [geneeskundeboek.nl]

Patients with FND usually present with two or more of the following: pronounced ocular hypertelorism, broadening of the nasal root, median facial cleft affecting the nose [radiologykey.com]

Postaxial Oligodactyly, Tetramelic

lip Bilateral cleft lip and palate Median cleft lip Hypopituitarism Omphalocele Spastic diplegia Dental malocclusion Spontaneous abortion Smooth philtrum Thin upper lip vermilion [mendelian.co]

cleft lip corpus callosum lipoma skin polyps Median nodule of the upper lip Mediastinal endodermal sinus tumors Mediastinal syndrome Mediterranean fever Medium-chain Acyl-CoA [sosu.us]

[…] hearing loss * Cleft tongue syndrome * Cleft upper lip median cutaneous polyps * Cleidocranial dysplasia * Cleidorhizomelic syndrome * C-like syndrome * Cloacal exstrophy [medicalgeek.com]

Joubert Syndrome Type 10

SR(P)S Beemer-Langer type is characterized clinically by median cleft lip,’ small chest with extremely short ribs, protuberant abdomen with umbilical hernia, and ambiguous [docksci.com]

Variability of expression of oral-facial-digital syndrome type I in 15 Saudi girls: Why is there a high rate of median cleft lip in the phenotype?. [123dok.net]

Holoprosencephaly Type 7

Most commonly associated with facial abnormalities such as cyclopia, ethmocephaly, cebocephaly, and median cleft lip. [radiopaedia.org]

It is usually obvious at birth even if antenatal diagnosis has not been made, due to associated midline facial anomalies including 3: proboscis cyclopia cleft lip and/or palate [radiopaedia.org]

[…] ocular hypotelorism solitary median maxillary central incisor Additionally, these children also have systemic problems, with poor feeding, hypothalamic/pituitary dysfunction [radiopaedia.org]

Holoprosencephaly Type 8

Most commonly associated with facial abnormalities such as cyclopia, ethmocephaly, cebocephaly, and median cleft lip. [radiopaedia.org]

It is usually obvious at birth even if antenatal diagnosis has not been made, due to associated midline facial anomalies including 3: proboscis cyclopia cleft lip and/or palate [radiopaedia.org]

[…] ocular hypotelorism solitary median maxillary central incisor Additionally, these children also have systemic problems, with poor feeding, hypothalamic/pituitary dysfunction [radiopaedia.org]

Holoprosencephaly Type 4

Most commonly associated with facial abnormalities such as cyclopia, ethmocephaly, cebocephaly, and median cleft lip. [radiopaedia.org]

It is usually obvious at birth even if antenatal diagnosis has not been made, due to associated midline facial anomalies including 3: proboscis cyclopia cleft lip and/or palate [radiopaedia.org]

[…] ocular hypotelorism solitary median maxillary central incisor Additionally, these children also have systemic problems, with poor feeding, hypothalamic/pituitary dysfunction [radiopaedia.org]

Holoprosencephaly Type 9

Most commonly associated with facial abnormalities such as cyclopia, ethmocephaly, cebocephaly, and median cleft lip. [radiopaedia.org]

It is usually obvious at birth even if antenatal diagnosis has not been made, due to associated midline facial anomalies including 3: proboscis cyclopia cleft lip and/or palate [radiopaedia.org]

[…] ocular hypotelorism solitary median maxillary central incisor Additionally, these children also have systemic problems, with poor feeding, hypothalamic/pituitary dysfunction [radiopaedia.org]

Sakoda Complex

[Sphenoethmoidal meningoencephalocele associated with agenesis of corpus callosum and median cleft lip and palate--report of two cases (author's transl)]. [pubmed.ncbi.nlm.nih.gov]

cleft lip and palate. [link.springer.com]

: Sphenoethmoidal meningoencephalocele associated with agenesis of corpus callosum and median cleft lip and palate: case report. J. [syndromefinder.ncchd.go.jp]

Short Rib-Polydactyly Syndrome Type Majewski

cleft lip and palate, a ventriculoseptal defect and cystic kidneys. [medical-dictionary.thefreedictionary.com]

[…] markedly short ribs, short limbs, polydactyly and multiple anomalies including a narrow thorax with hypoplastic lungs, extreme polysyndactyly, dysproportionate dwarfism, median [medical-dictionary.thefreedictionary.com]

Holoprosencephaly Type 6

Familial alobar holoprosencephaly (Arhinencephaly) with median cleft lip and palate. [link.springer.com]

Alobar holoprosencephaly (arhinencephaly) with median cleft lip and palate: Clinical electroencephalographic and nosologic considerations. Confin. neurol. [link.springer.com]

Face predicts brain: Diagnostic significance of median facial anomalies for holoprosencephaly (Archinencephaly). [link.springer.com]

Holoprosencephaly Type 2

lip that occurs in the middle of the lip (median cleft lip) or on both sides (bilateral cleft lip). [rarediseases.info.nih.gov]

The other had multiple facial abnormalities such as hypotelorism, median cleft lip and palate, and preauricular skin tag. [cjhr.org]

Familial alobar holoprosencephaly (Arhinencephaly) with median cleft lip and palate. Neurology 13, 913–918 (1963) Google Scholar 2. [link.springer.com]

Short Rib-Polydactyly Syndrome Type Beemer-Langer

[…] bridge ( 1867273 ) median cleft lip ( 1867273 ) median alveolar ridge ( 1867273 ) grooved palate ( 1867273 ) accessory frenula ( 1867273 ) small tongue ( 1867273 ) hypertelorism [humpath.com]

We present premature female twin fetuses with concordant extremely shortened ribs, short limbs, macrocephaly, median cleft upper lip and facial dysmorphism. [ncbi.nlm.nih.gov]

cleft lip and palate ; Narrow chest ; Natal tooth ; Neonatal death ; Omphalocele ; Patent ductus arteriosus ; Patent foramen ovale ; Periportal fibrosis ; Polyhydramnios [mousephenotype.org]

Orofaciodigital Syndrome Type 5

Synonyms OFD5 Oral-facial-digital syndrome 5 Thurston syndrome Polydactyly postaxial with median cleft of upper lip OFD syndrome 5 Orofaciodigital syndrome V Oral facial digital [rarediseases.org]

Orpha Number: 2919 Definition Oral-facial-digital syndrome, type 5 is characterized by median cleft of the upper lip, postaxial polydactyly of hands and feet, and oral manifestations [rareguru.com]

Causes Advocacy and Support Groups Research Summary A rare orofaciodigital syndrome characterized by median cleft of the upper lip, postaxial polydactyly of hands and feet [rarediseases.info.nih.gov]