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37 Possible Causes for Mental Retardation, Onset of Dysarthria in Third Decade of Life

  • Hallervorden-Spatz Syndrome

    Clinical features Dystonia Dysarthria Spasticity Choreoathetosis Parkinsonism Hyperreflexia Extensor toe signs Onset in first to third decade of life Gait change / loss of[ncbi.nlm.nih.gov] Clinical presentations include dystonia, dysarthria, dementia, severe mental retardation and ataxia with rare features as rigidity, choreoathetosis, seizures, optic atrophy[medresearch.in] At about 1 1/2 years of age the patients with Hallerworden‐Spatz disease developed clinical signs including progressive extrapyramidal motor disorder and mental retardation[doi.org]

  • Spinocerebellar Ataxia Type 1

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com] SCA 13 is developed in childhood and mental retardation is one of the major problems with the child.[healthsaline.com] .), NS22920 and NS45667 (to H.T.O.) and National Institute of Child Health and Human Development grant HD024064 (to the Baylor College of Medicine Mental Retardation and Developmental[doi.org]

  • Hereditary Orotic Aciduria

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Abstract Urine from 1,358 mentally retarded subjects was screened for the presence of elevated concentrations of orotic acid and orotidine.[ncbi.nlm.nih.gov] A 3-year-old boy who had been diagnosed as having cerebral palsy and mental retardation presented himself with an increase in excretion of urinary orotic acid.[ncbi.nlm.nih.gov]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Mild mental retardation. Usually not diagnosed until after puberty. One Barr body seen on buccal smear.[kumc.edu] 38 8 CAPN1 Spastic paraplegia 76, autosomal recessive AR 6 16 CASK Mental retardation and microcephaly with pontine and cerebellar hypoplasia, FG syndrome, Mental retardation[blueprintgenetics.com]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Ankyrin-B (N105/13, N105/17) LONG QT SYNDROME 4 CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED Ataxin-1 (N76/3, N76/8) SPINOCEREBELLAR ATAXIA 1 CASK (K56A/50) MENTAL RETARDATION AND[neuromab.ucdavis.edu] 38 8 CAPN1 Spastic paraplegia 76, autosomal recessive AR 6 16 CASK Mental retardation and microcephaly with pontine and cerebellar hypoplasia, FG syndrome, Mental retardation[blueprintgenetics.com]

  • Autosomal Recessive Spinocerebellar Ataxia Type 17

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Only 2 truncating mutations were reported in homozygosity, one of which (c.1150-1151del) was associated with juvenile or adolescent onset and mental retardation, whereas we[spatax.wordpress.com] Individuals with a premutation do not manifest mental retardation, which is classical phenotype of Fragile X syndrome.[e-jmd.org]

  • Spinocerebellar Ataxia Type 13

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com] "Mapping of spinocerebellar ataxia 13 to chromosome 19q13.3-q13.4 in a family with autosomal dominant cerebellar ataxia and mental retardation".[en.wikipedia.org] "Mapping of spinocerebellar ataxia 13 to chromosome 19q13.3-q13.4 in a family with autosomal dominant cerebellar ataxia and mental retardation." .[ipfs.io]

  • Autosomal Dominant Spastic Ataxia Type 1

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Volcke Ph, Dereymaeker AM, Fryns JP, Van den Berghe H: On the nosology of moderate mental retardation with special attention to X-linked mental retardation.[karger.com] 38 8 CAPN1 Spastic paraplegia 76, autosomal recessive AR 6 16 CASK Mental retardation and microcephaly with pontine and cerebellar hypoplasia, FG syndrome, Mental retardation[blueprintgenetics.com]

  • Autosomal Recessive Spinocerebellar Ataxia

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] 32 7 CAPN1 Spastic paraplegia 76, autosomal recessive AR 6 14 CASK Mental retardation and microcephaly with pontine and cerebellar hypoplasia, FG syndrome, Mental retardation[blueprintgenetics.com] The first symptoms include ataxia, muscle weakness, mental retardation, and cataracts.[ataxiacenter.umn.edu]

  • X-Linked Spinocerebellar Ataxia Type 5

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Mental Retardation, X-Linked 72 3 Mental Retardation, X-Linked 9 2 Mental Retardation, X-Linked 90 3 Mental Retardation, X-Linked 93 2 Mental Retardation, X-Linked 96 1 Mental[preventiongenetics.com] Mild mental retardation. Usually not diagnosed until after puberty. One Barr body seen on buccal smear.[kumc.edu]

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