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5,012 Possible Causes for Mental Retardation, Psychomotor Development Profoundly Delayed, Wide Space Between the First and Second Toe

  • Seckel Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] It is extremely rare and typically causes dwarfism, mental retardation, intrauterine growth retardation and microcephaly.[symptoma.com] The syndrome is characterized by severe intrauterine and postnatal growth retardation with proportional dwarfism, typical beak-like triangular nose, and mental retardation[ncbi.nlm.nih.gov]

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Abstract Although there is considerable variability, most individuals with Down syndrome have mental retardation and speech and language deficits, particularly in language[oadoi.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org]

    Missing: Psychomotor Development Profoundly Delayed
  • Dubowitz Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] , short stature, microcephaly, mild mental retardation with behavior problems, eczema, and unusual and distinctive faci DUBOWITZ SYNDROME edit English Dubowitz syndrome Human[wikidata.org] Dubowitz syndrome is an autosomal recessive disorder of growth retardation, characteristic face, mild mental retardation, and eczema originally described by Dubowitz [1965[ncbi.nlm.nih.gov]

    Missing: Psychomotor Development Profoundly Delayed
  • Ring Chromosome 10

    […] deficiency Mental retardation Mental retardation, nonspecific Mental-retardation [ more ] 0001249 Intrauterine growth retardation Prenatal growth deficiency Prenatal growth[rarediseases.info.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] eyelids 0000494 Frontal bossing 0002007 Hypertelorism Wide-set eyes Widely spaced eyes [ more ] 0000316 Hypocalcemia Low blood calcium levels 0002901 Intellectual disability Mental[rarediseases.info.nih.gov]

    Missing: Psychomotor Development Profoundly Delayed
  • Hyperphosphatasia-Intellectual Disability Syndrome 1

    (OMIM phenotype number #239300 ) Hyperphosphatasia with mental retardation syndrome (HPMRS), also called "Mabry syndrome", is a rare autosomal recessive form of intellectual[iofbonehealth.org] It is characterized by a cluster of irreversible BIRTH DEFECTS including abnormalities in physical, mental, and behavior development (such as FETAL GROWTH RETARDATION; MENTAL[bioportfolio.com] Hyperphosphatasia with mental retardation syndrome Other names image_size 240px This condition is inherited in an autosomal recessive manner Hyperphosphatasia with mental[en.wikipedia.org]

    Missing: Wide Space Between the First and Second Toe
  • Cutis Laxa

    Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] While the patients with GORAB mutations have severe osteopenia, the patients with PYCR1 mutations have severe mental retardation.[ncbi.nlm.nih.gov] , mental retardation, and tumor predisposition.[ncbi.nlm.nih.gov]

    Missing: Psychomotor Development Profoundly Delayed
  • Kenny-Caffey Syndrome Type 1

    Mental retardation of varying degree was found in all patients. All had severe intrauterine and postnatal growth retardation. Four patients have died.[scienceopen.com] space between the first and second toes.[medcraveonline.com] Disorders stemming from this gene include mental retardation, and growth retardation.[amazingwristbands.com]

    Missing: Psychomotor Development Profoundly Delayed
  • Early Infantile Epileptic Encephalopathy Type 28

    7 MRD7 614104 Genetic Test Registry Mental Retardation, Autosomal Dominant 8 MRD8 614254 Genetic Test Registry Mental Retardation, X-Linked 1 Mental Retardation, X-Linked[ukgtn.nhs.uk] retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) Mental retardation, CASK-related, X-linked Mental retardation, autosomal dominant 5 (MRD5) Myoclonic[ncbi.nlm.nih.gov] retardation; early infantile epileptic encephalopathy 1; Partington X-Linked Mental Retardation Syndrome XL, XLR 7 CACNA1A 601011 episodic ataxia type 2; familial hemiplegic[centogene.com]

    Missing: Wide Space Between the First and Second Toe
  • Seckel Syndrome Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes. nd. 3pp. www.nlm.nih.gov/cgi/jablonski/syndrome_cgi?[rarediseases.org] The presence of mental retardation and neurologic signs is one of the peculiar features of this syndrome, but only recently were rare cases of malformation of cortical development[journals.sagepub.com]

    Missing: Psychomotor Development Profoundly Delayed
  • Impacted Cerumen

    Moreover, a strong propensity for recurrent cerumen impaction in the mentally retarded population was found.[ncbi.nlm.nih.gov] Abstract The incidence of occlusion of the external auditory canal due to impacted cerumen was determined for 44 mentally retarded subjects in comparison with 44 nonretarded[ncbi.nlm.nih.gov] Impacted cerumen is a major cause of primary care consultation, and a common comorbidity in ENT patients, the elderly, infirm and people with mental retardation.[ncbi.nlm.nih.gov]

    Missing: Psychomotor Development Profoundly Delayed Wide Space Between the First and Second Toe

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