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18 Possible Causes for Mental Retardation, Sleep Apnea, Wide Space Between the First and Second Toe

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Abstract Although there is considerable variability, most individuals with Down syndrome have mental retardation and speech and language deficits, particularly in language[oadoi.org] Obstructive sleep apnea (OSA) is more common in children with Down syndrome, affecting up to 60% of patients, and may persist in up to 50% of patients after adenotonsillectomy[ncbi.nlm.nih.gov]

  • Dubowitz Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] , short stature, microcephaly, mild mental retardation with behavior problems, eczema, and unusual and distinctive faci DUBOWITZ SYNDROME edit English Dubowitz syndrome Human[wikidata.org] Severe obstructive sleep apnea in a patient with spinal muscle atrophy. Chest . 2004 Nov. 126(5):1705-7. [Medline] . [Full Text] . Yasuma F, Kuru S, Konagaya M.[emedicine.medscape.com]

  • Kleiner Holmes Syndrome

    […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] Alopecia-Mental Retardation Syndrome 1 Alopecia-Mental Retardation Syndrome 2 Alopecia-Mental Retardation Syndrome 3 Alopecia-Mental Retardation Syndrome with Convulsions[rgd.mcw.edu] A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic[books.google.de]

  • Familial Congenital Nasolacrimal Duct Obstruction

    space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] […] retinopathy and mental retardation; {268050}), which has been mapped to chromosome 8q21.3-q22.1.[mendelian.co] There was no family history of such a condition, but the patient was mildly mentally retarded since childhood.[ijo.in]

  • Atelosteogenesis Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Retardation, Characteristic Facies, Short Stature, and Skeletal Anomalies KBGS 148050 Genetic Test Registry Kniest Dysplasia 156550 Genetic Test Registry Larsen Syndrome[ukgtn.nhs.uk] […] or commonly referred to as Sleep Apnea. 18. frequent respiratory infections 19. frequent ear infections. 20. connective tissue disorder 21. dislocation of the shoulders 22[tawnymullins77.blogspot.com]

  • Trisomy 10p

    spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com] Besides multiple minor dysmorphias the patient showed severe mental retardation, small stature, hypotonia, retarded bone age.[ncbi.nlm.nih.gov] Hippokrates (1977) 0.75 [Apnea conditions in sleep and sudden infant death]. Hippokrates (1976) 0.75 [Contribution to the Sjögren-Larsson syndrome (author's transl)].[pubrank.carbocation.com]

  • Craniofrontonasal Dysplasia

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The patient’s initial symptoms included frequent headaches, history of obstructive sleep apnea, and abnormal head shape.[ncbi.nlm.nih.gov] retardation.[link.springer.com]

  • Russell-Silver Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] At follow-up, five of the 15 patients exhibited late catch-up growth and had normal height, six had developmental delays or mental retardation, and asymmetry was present in[ncbi.nlm.nih.gov] Apnea My Son Noonan Syndrome Chronic Illness Chronic Pain Forward Global Genes - Building awareness and communities to support and find treatments for Rare Diseases Mom on[pinterest.se]

  • Weaver Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The clinical manifestations are mild mental retardation, overgrowth with accelerated bone age, minor facial anomalies including broad forehead, mild hypertelorism, depressed[ncbi.nlm.nih.gov] Pathophysiology of sleep apnea. Physiol Rev (2010) 90:47–112. 4. American Academy of Sleep Medicine.[medichub.ro]

  • MORM Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Based on the experience of mental retardation as it presents in that population, these individuals had mild to moderate mental retardation.[nature.com] "Interactions Between Obesity and Obstructive Sleep Apnea" . Chest . 137 (3): 711–719. doi : 10.1378/chest.09-0360 . PMC 3021364 .[en.wikipedia.org]

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