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361 Possible Causes for Mental Retardation of Variable Severity

  • Alzheimer Disease

    retardation, mental illness or any other life long mental health disorders.[] ANALYTICAL APPROACH All demographic variables, measures of severity of dementia and comorbid conditions were gathered at initial MDS assessment on admission to the nursing[] […] coefficient (0.81), and proved of research value. 48 49 Patients were at least 65 years of age at their initial MDS assessment, and we excluded patients with a history of mental[]

  • Germ Cell Tumor

    Prader-Willi syndrome (PWS) is a multisystem genetic disorder characterized by lack of satiety leading to morbid obesity, variable degrees of mental retardation, behavior[] The underlying genetic cause for PWS is an imprinting defect resulting from a lack of expression of several paternally inherited genes embedded within the 15q11.2-q13 region[]

  • Pyruvate Carboxylase Deficiency

    Children with inborn errors of PC metabolism have lactic acidosis, hypoglycemia, and mental retardation.[] The variable severity of the clinical phenotype is dependent on both genetic and environmental factors.[]

  • Mental Retardation

    Mental retardation in the affected boy can recognize several mechanisms such as variable expressivity, non-penetrance, multifactorial/polygenic inheritance, recessive inheritance[] Abstract BACKGROUND: Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation syndrome (MCLMR) is a rare autosomal dominant disorder with variable[] Affected males showed non-specific, non-progressive mental retardation ranging from severe to moderate, without seizures, whereas carrier females showed highly variable cognitive[]

  • Early Infantile Epileptic Encephalopathy Type 2

    retardation, severe Severe mental retardation [ more ] 0010864 Neonatal onset 0003623 Severe global developmental delay 0011344 Spastic paraplegia 0001258 Spastic tetraplegia[] Myoclonic status in nonprogressive encephalopathies Affected children have a poor prognosis, experiencing developmental regression, and eventual severe mental retardation.[] […] degree of psychomotor delay and cognitive impairment, ranging from mild to severe mental retardation [23].[]

  • Muscular Dystrophy-Dystroglycanopathy Type C1

    The phenotype is characterized by weakness apparent after walking is achieved; mental retardation and mild brain anomalies are variable.[] The most severe end of the phenotypic spectrum of dystroglycanopathies is represented by congenital muscular dystrophy with brain and eye anomalies, previously designated[]

  • Epilepsy with Continuous Spike-and-Slow-Waves during Sleep

    Myoclonic status in nonprogressive encephalopathies Affected children have a poor prognosis, experiencing developmental regression, and eventual severe mental retardation.[] Myoclonic-astatic epilepsy (Doose syndrome) The prognosis is variable and difficult to predict.[] After several years, the seizures may remit in 54-89% of patients. [36] The cognitive outcome ranges from no sequelae in most cases to progressive cognitive impairment in[]

  • Isolated Congenital Sclerocornea

    mental retardation, spastic diplegia, and hypogonadism. – Oculodentodigital dysplasia (ODDD): caused by mutation in GJA1.[] […] recessive syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe[] Oculodentodigital dysplasia is phenotypically variable syndrome that can include facial dysmorphisms (syndactyly and camptodactyly), digit malformations, small teeth and microphthalmia[]

  • Mowat-Wilson Syndrome

    The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease[] Genotype-phenotype analysis confirmed that ZFHX1B deletions and stop mutations result in a recognizable facial dysmorphism with associated severe mental retardation and variable[] Mowat-Wilson syndrome (MWS) is a recently delineated mental retardation (MR)-multiple congenital anomaly syndrome, characterized by typical facies, severe MR, epilepsy, and[]

  • Autosomal Dominant Prognathism

    Several members had impaired intellect, and 1 was severely mentally retarded.[] Variable neurologic findings included dysphagia, nystagmus, abnormal gait, and abnormal involuntary movements.[]

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