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361 Possible Causes for Mental Retardation of Variable Severity

  • Alzheimer Disease

    retardation, mental illness or any other life long mental health disorders.[doi.org] ANALYTICAL APPROACH All demographic variables, measures of severity of dementia and comorbid conditions were gathered at initial MDS assessment on admission to the nursing[doi.org] […] coefficient (0.81), and proved of research value. 48 49 Patients were at least 65 years of age at their initial MDS assessment, and we excluded patients with a history of mental[doi.org]

  • Germ Cell Tumor

    Prader-Willi syndrome (PWS) is a multisystem genetic disorder characterized by lack of satiety leading to morbid obesity, variable degrees of mental retardation, behavior[ncbi.nlm.nih.gov] The underlying genetic cause for PWS is an imprinting defect resulting from a lack of expression of several paternally inherited genes embedded within the 15q11.2-q13 region[ncbi.nlm.nih.gov]

  • Pyruvate Carboxylase Deficiency

    Children with inborn errors of PC metabolism have lactic acidosis, hypoglycemia, and mental retardation.[ncbi.nlm.nih.gov] The variable severity of the clinical phenotype is dependent on both genetic and environmental factors.[ncbi.nlm.nih.gov]

  • Mental Retardation

    Mental retardation in the affected boy can recognize several mechanisms such as variable expressivity, non-penetrance, multifactorial/polygenic inheritance, recessive inheritance[ncbi.nlm.nih.gov] Abstract BACKGROUND: Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation syndrome (MCLMR) is a rare autosomal dominant disorder with variable[ncbi.nlm.nih.gov] Affected males showed non-specific, non-progressive mental retardation ranging from severe to moderate, without seizures, whereas carrier females showed highly variable cognitive[latunisiemedicale.com]

  • Early Infantile Epileptic Encephalopathy Type 2

    retardation, severe Severe mental retardation [ more ] 0010864 Neonatal onset 0003623 Severe global developmental delay 0011344 Spastic paraplegia 0001258 Spastic tetraplegia[rarediseases.info.nih.gov] Myoclonic status in nonprogressive encephalopathies Affected children have a poor prognosis, experiencing developmental regression, and eventual severe mental retardation.[emedicine.medscape.com] […] degree of psychomotor delay and cognitive impairment, ranging from mild to severe mental retardation [23].[journals.plos.org]

  • Muscular Dystrophy-Dystroglycanopathy Type C1

    The phenotype is characterized by weakness apparent after walking is achieved; mental retardation and mild brain anomalies are variable.[link.springer.com] The most severe end of the phenotypic spectrum of dystroglycanopathies is represented by congenital muscular dystrophy with brain and eye anomalies, previously designated[link.springer.com]

  • Epilepsy with Continuous Spike-and-Slow-Waves during Sleep

    Myoclonic status in nonprogressive encephalopathies Affected children have a poor prognosis, experiencing developmental regression, and eventual severe mental retardation.[emedicine.medscape.com] Myoclonic-astatic epilepsy (Doose syndrome) The prognosis is variable and difficult to predict.[emedicine.medscape.com] After several years, the seizures may remit in 54-89% of patients. [36] The cognitive outcome ranges from no sequelae in most cases to progressive cognitive impairment in[emedicine.medscape.com]

  • Isolated Congenital Sclerocornea

    mental retardation, spastic diplegia, and hypogonadism. – Oculodentodigital dysplasia (ODDD): caused by mutation in GJA1.[bredagenetics.com] […] recessive syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe[bredagenetics.com] Oculodentodigital dysplasia is phenotypically variable syndrome that can include facial dysmorphisms (syndactyly and camptodactyly), digit malformations, small teeth and microphthalmia[bredagenetics.com]

  • Mowat-Wilson Syndrome

    The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease[ncbi.nlm.nih.gov] Genotype-phenotype analysis confirmed that ZFHX1B deletions and stop mutations result in a recognizable facial dysmorphism with associated severe mental retardation and variable[ncbi.nlm.nih.gov] Mowat-Wilson syndrome (MWS) is a recently delineated mental retardation (MR)-multiple congenital anomaly syndrome, characterized by typical facies, severe MR, epilepsy, and[ncbi.nlm.nih.gov]

  • Autosomal Dominant Prognathism

    Several members had impaired intellect, and 1 was severely mentally retarded.[findzebra.com] Variable neurologic findings included dysphagia, nystagmus, abnormal gait, and abnormal involuntary movements.[findzebra.com]

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