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1,065 Possible Causes for Metabolic Alkalosis, Mutation in the Tight Junction Protein 2 Gene

  • Hypomagnesemia

    Laboratory tests showed hypokalemia, metabolic alkalosis, hypocalciuria, and hypomagnesemia related to genetically proven GS.[ncbi.nlm.nih.gov] It has been recently attributed to a mutation in the Claudin 16 (CLDN 16) gene of the Paracellin-1 (PCLN-1) tight junction protein.[ncbi.nlm.nih.gov] In this case, a third factor, Gitelman syndrome, resulted in persistent hypomagnesemia with metabolic alkalosis and, while separate from her eating disorder, simultaneously[ncbi.nlm.nih.gov]

  • Autosomal Dominant Primary Hypomagnesemia with Hypocalciuria

    In patients with FXYD2 mutations, no hypokalemia or metabolic alkalosis is observed. In contrast, in patients with HNF1B mutations, hypokalemia can be detected.[orpha.net] […] of the claudin 16 gene (3q27) coding for a tight junctional protein that regulates paracellular Mg(2 ) transport in the loop of Henle; (4) autosomal-dominant hypoparathyroidism[ncbi.nlm.nih.gov] alkalosis Normotension Elevated plasma renin level Hypokalemia Hypochloremia Metabolic alkalosis Hypomagnesemia Hypocalciuria Normotension Hypertension Hypokalemia Metabolic[medbullets.com]

  • Vomiting of Pregnancy

    alkalosis. 1,3,15 It is recommended to replete with thiamine if significant electrolyte abnormalities exist to protect against Wernicke’s.[emdocs.net] Serum electrolytes and ketones: Assess electrolyte status to evaluate for low potassium or sodium, identify hyperchloremic metabolic alkalosis or acidosis, and evaluate renal[emedicine.medscape.com] Clinical findings include dehydration, acidosis due to inadequate nutrition, alkalosis due to loss of hydrochloride and hypokalaemia.[bmcmedicine.biomedcentral.com]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Acidosis

    Definition A combined respiratory acidosis / metabolic alkalosis will result in elevated PaCO 2 and serum bicarbonate.[openanesthesia.org] metabolic alkalosis.[acid-base.com] Which process is the primary disorder (e.g. primary respiratory acidosis with metabolic compensation versus primary metabolic alkalosis with respiratory compensation) is dependent[openanesthesia.org]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Hypovolemia

    Lactated Ringer's infusate should not be given in patients with severe metabolic alkalosis, lactic acidosis with decreased lactate clearance, or severe hyperkalemia, and in[ncbi.nlm.nih.gov] alkalosis.[ 1 ] All resuscitation fluids can contribute to the formation of interstitial edema, especially under different inflammatory conditions and confounding medical[ncbi.nlm.nih.gov] […] extracellular fluid) has shown no harmful effects in any particular type of patient.[ 8 , 9 ] However, such solution have demerits of hypotonicity, hyperlactatemia, and metabolic[ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Gitelman Syndrome

    Investigations revealed hypokalemia at 2.7 mmol/L, metabolic alkalosis, hypocalciuria and normal serum magnesium level.[ncbi.nlm.nih.gov] The laboratory tests revealed hypokalemia, hypomagnesemia, metabolic alkalosis and hypocalciuria. We started intravenous magnesium and potassium infusion.[ncbi.nlm.nih.gov] Gitelman syndrome is a rare inherited renal tubulopathy associated with metabolic alkalosis and electrolyte disorders.[ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Milk-Alkali Syndrome

    Metabolic Alkalosis Metabolic alkalosis has the capacity to affect calcium homeostasis at several critical sites.[cjasn.asnjournals.org] The defining features of the syndrome are the triad: metabolic alkalosis, hypercalcemia and renal failure.[acutecaretesting.org] alkalosis.[en.wikipedia.org]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Hypertrophic Pyloric Stenosis

    To investigate the influence of enhanced metabolic alkalosis (MA) on cerebral (c-rSO 2 ) and renal (r-rSO 2 ) tissue oxygenation, two-site near-infrared spectroscopy (NIRS[ncbi.nlm.nih.gov] Logistic regression analysis demonstrated that the prevalence of metabolic alkalosis increased across the decade, whereas the prevalence of metabolic acidosis decreased and[ncbi.nlm.nih.gov] After the correction of systemic metabolic alkalosis and pH normalization, cerebrospinal fluid can keep a state of metabolic alkalosis.[ncbi.nlm.nih.gov]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Low Chloride

    Excessive intake may result in hypertension, oedema, hypokalaemia and metabolic alkalosis. 7 7.2.7 Usefulness of Urinary Chloride Measurements Metabolic alkalosis may be divided[anaesthesiamcq.com] Chronic low Cl- levels can leading to metabolic alkalosis, low fluid volume in the blood serum and urinary potassium loss.[allnutriments.blogspot.com] Low chloride levels can also indicate that blood pH is higher than normal, a condition called metabolic alkalosis.[reference.com]

    Missing: Mutation in the Tight Junction Protein 2 Gene
  • Hypercalcemia

    […] osteoclast and bone osteolytic activity Prevents osteoclast formation Increases urinary excretion of calcium Other factors altering serum calcium include the following: Metabolic[emedicine.medscape.com] PTH Life-long and asymptomatic hypercalcemia Hypercalcemia without hypercalciuria in patients and family members Milk-alkali syndrome No hypercalciuria Metabolic alkalosis[web.archive.org] alkalosis, which causes an increase in tubular calcium reabsorption Phosphate-induced decrease of serum calcium levels and increase of PTH Stimulation of osteoclasts by cytokines[emedicine.medscape.com]

    Missing: Mutation in the Tight Junction Protein 2 Gene

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