Metaphyseal Cupping Causes & Reasons

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Metaphyseal Cupping Symptom Checker: Possible causes include Platyspondyly. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Metaphyseal Cupping,

Negated

None

Unsure

None

Possible Causes

Platyspondyly

Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. [malacards.org]

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Metaphyseal Acroscyphodysplasia

Title Other Names: Cupped metaphyses and cone-shaped epiphyses of knees with brachydactyly; Wedge-shaped epiphyses of knees; Bellini syndrome; Cupped metaphyses and cone-shaped [rarediseases.info.nih.gov]

Based on two independent personal cases and a pair of sibs from the literature, we delineate a new category of bone dysplasia with cup-shaped large metaphyses, for which the [ncbi.nlm.nih.gov]

MalaCards based summary : Metaphyseal Acroscyphodysplasia, is also known as cupped metaphyses and cone-shaped epiphyses of knees with brachydactyly. [malacards.org]

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Schmid Metaphyseal Chondrodysplasia

These changes were subtle and consisted of shortening of the tubular bones and metaphyseal cupping of the proximal phalanges and metacarpals. [ncbi.nlm.nih.gov]

[…] chondrodysplasia ; Metaphyseal cupping of metacarpals ; Metaphyseal cupping of proximal phalanges ; Mild short stature ; Platyspondyly ; Proximal femoral metaphyseal abnormality [mousephenotype.org]

[…] chondrodysplasia 0005871 Metaphyseal cupping of metacarpals Cupping of wide portion of long bone of hand 0006028 Metaphyseal cupping of proximal phalanges 0006208 Mild short [rarediseases.info.nih.gov]

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Vitamin D Deficiency

The radiography of the wrist showed evidence of cupping, fraying, metaphyseal widening, and demineralization of the distal radial and ulnar metaphyses. [ncbi.nlm.nih.gov]

[…] of metaphyses - Osteopenia Principles of treatment Treatment choice should be balanced by the following considerations: safety of treatment adherence considerations, i.e. [starship.org.nz]

Anteroposterior and lateral radiographs of the wrist of an 8-year-old boy with rickets demonstrates cupping and fraying of the metaphyseal region. [emedicine.medscape.com]

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Cystitis

Mild hand involvement often includes shortening of the tubular bones and metaphyseal cupping of the metacarpals and proximal phalanges. [ncbi.nlm.nih.gov]

Radiographs show metaphyseal irregularities of the long bones (e.g., splaying, flaring, cupping); shortening of the tubular bones; widened growth plates; coxa vara; and anterior [ncbi.nlm.nih.gov]

Radiologic hallmarks include short ribs with flared and cupped anterior ends, mild spondylar dysplasia, lacy iliac crests, and metaphyseal irregularities essentially confined [ncbi.nlm.nih.gov]

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Metaphyseal Chondrodysplasia, Spahr Type

Pathology Classification Schmid type - mild type, due to mutation in type X collagen ( COL10A1 gene), metaphyses are cupped resembling rickets Pena and Vaandrager type - intermediate [radiopaedia.org]

Major radiographic features in infancy included flared,cupped, and ragged metaphyses of all long bones, delayedmaturation of the scaphoid, trapezoid, and trapezium bones,wide [docslide.net]

Metaphyseal chondrodysplasia (also known as metaphyseal dysplasia or dysostosis) is a type of skeletal dysplasia. [radiopaedia.org]

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Spondylometaphyseal Dysplasia Type Kozlowski

The original report describes an Iranian infant with mild rhizomelic limb shortening, severe metaphyseal cupping and irregularity and platyspondyly who died shortly after [ncbi.nlm.nih.gov]

[…] is a rare, perinatally lethal osteochondrodysplasia comprising minor facial, cardiac and cerebral anomalies, rhizomelic shortness of long bones, metaphyseal cupping and irregularity [updoc.site]

KEY WORDS: lethal chondrodysplasia; platyspondyly; metaphyseal dysplasia; Sedaghatian dysplasia; AR inheritance INTRODUCTION Spondylometaphyseal dysplasia type Sedaghatian [updoc.site]

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Schneckenbecken Dysplasia

cupping, squared iliac bones, horizontal acetabular roofs, hypoplastic ischia and pubis. read more Next Generation Sequencing NGS/Del Dup Comprehensive Turnaround Time: Typically [ctgt.net]

Radiographic findings include very delayed bone maturation particularly at the knee, marked shortness of the metacarpals/ metatarsals and phalanges with metaphyseal cupping [ncbi.nlm.nih.gov]

[…] chondrodysplasia (OMIM 250220; short ribs with splayed posterior ends and cupped anterior ribs ends, mildly shortened tubular bones with metaphyseal cupping and irregularity [journals.lww.com]

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Fracture

Radiologic changes that should lead to further evaluation for possible deficiency include cupping and fraying of the metaphyses, sickle-shaped metaphyseal spurs, significant [pediatrics.aappublications.org]

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Growth Failure

Figure 2: Minimal cupping at the phalangeal basis, short phalanges, short and broad metacarpal and metatarsal bones, cone-shaped epiphysis and metaphyseal cupping at middle [advbiores.net]

[…] and fraying of the metaphyses and a widened epiphyseal plate. 26 Management Nutritional rickets is managed by advice about a balanced diet, correction of predisposing risk [slideplayer.com]

Knee metaphyseal flaring with mild epiphyseal dysplasia and slender diaphysis of long bones. [advbiores.net]

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Hyponatremia

There were demonstrable improvements in metaphyseal fraying and cupping within 1 month of initiating therapy, followed by almost complete resolution of all metaphyseal abnormalities [hindawi.com]

Stillborn infants typically have irregular, short, and deep cup-shaped metaphyses, hypoplastic or absent bones, and thin diaphysis. [biodonsys.com]

The skeletal survey was interpreted at 2 months of age as being consistent with rickets, including metaphyseal cupping and fraying in multiple long bones. [hindawi.com]

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Cystocele

Mild hand involvement often includes shortening of the tubular bones and metaphyseal cupping of the metacarpals and proximal phalanges. [ncbi.nlm.nih.gov]

Radiologic hallmarks include short ribs with flared and cupped anterior ends, mild spondylar dysplasia, lacy iliac crests, and metaphyseal irregularities essentially confined [ncbi.nlm.nih.gov]

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Fibrochondrogenesis

The ribs are typically short and wide and have metaphyseal cupping at both ends (summary by {9:Tompson et al., 2010}). [diseaseinfosearch.org]

Short, broad dumbell-shaped metaphyses. Pear shaped vertebral bodies. Short, distally cupped ribs. Eteson DJ, Adomian GE, Ornoy A et.al. [fetalultrasound.com]

Ribs are short and wide, cupped both anteriorly and posteriorly. The long bones are short and broad (dumb-bell shaped) with irregular metaphyses and peripheral spurs. [ncbi.nlm.nih.gov]

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Rathbun Syndrome

Bone deformities like metaphyseal cupping, craniosynostosis, brachycephaly or bowed and short limbs may be noticed and the child may learn how to walk later than his healthy [symptoma.com]

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Facioauriculoradial Dysplasia

Anteroposterior radiograph of the upper limbs after the reconstruction showed profound radial aplasia, metaphyseal cupping associated with hypoplastic/defective ossification [link.springer.com]

Figure 2 Anteroposterior radiograph of the upper limbs after the reconstruction showed profound radial aplasia, metaphyseal cupping associated with hypoplastic/defective ossification [link.springer.com]

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Thoracolaryngopelvic Dysplasia

Long bones in Shwachman syndrome may show some metaphyseal cupping, which may cause confusion with neonatal rickets (9). [czytelniamedyczna.pl]

cupping and fraying of tubular bones have also been observed in Jansen metaphyseal dysplasia (OMIM 156400), which differs by the presence of splayed rib ends and normal alkaline [journals.lww.com]

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Infantile Scurvy

A five year old girl presented with short femora, cupped distal metaphyses and flexion deformity of the knees suggesting previous epiphyseo-metaphyseal damage. [ncbi.nlm.nih.gov]

[…] band underlying Frankel line Pelkan spur: metaphyseal spurs which result in cupping of the metaphysis Adults osteopenia pathological fractures Other significant manifestations [radiopaedia.org]

[…] radiologic shadow surrounding epiphyseal centers of ossification, which may result from bleeding Frankel line: dense zone of provisional calcification Trümmerfeld zone: lucent metaphyseal [radiopaedia.org]

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Coxa Vara

[…] striking on radiological imaging, which includes metaphyseal cupping and fraying. [unboundmedicine.com]

Mild hand involvement often includes shortening of the tubular bones and metaphyseal cupping of the metacarpals and proximal phalanges. [ncbi.nlm.nih.gov]

[Case Reports] Cureus. 2020 Mar 23; 12(3):e7371.C Metaphyseal chondrodysplasia, Schmid type (MDSC) is a rare inherited autosomal disorder with characteristic skeletal deformities [unboundmedicine.com]

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Skeletal Dysplasia

[…] hypoplastic ilia, and short, misshapen tubular bones with minimal tubulation.10,19 Infantile hypophosphatasia (OMIM 241500) is associated with severe demineralization and metaphyseal [journals.lww.com]

Additionally, the presence of metaphyseal broadening, cupping and dense line of ossification about the knee can simulate rachitic changes. [en.wikipedia.org]

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Pathological Fracture

cupping and fraying (See Figure 2) Physeal widening Enlargement of costochondral junction Bowing of long bones (See Figure 3) Management: Oral doses of 5,000-15,000 IU/day [learn.pediatrics.ubc.ca]

[…] usually normal in hypophosphatemic rickets 25-OH Vitamin D – low in vitamin D deficiency GFR and Creatinine – to determine kidney function Radiographic Findings: Osteopenia Metaphyseal [learn.pediatrics.ubc.ca]

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Pseudoachondroplasia

metaphyseal cupping. [slideshare.net]

Leg radiographs depicting dysplastic distal femoral and proximal tibial epiphyses, and distal femoral metaphyseal broadening, cupping, irregularities (white arrows) and radiolucent [en.wikipedia.org]

 thesplayed and cupped metaphyses as well as the shortening of the leg 13.  the short, thick tubular bones. 14.  characteristictrident hand, with separation of the third [slideshare.net]

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Non-Syndromic Ocular Stickler Syndrome Type 1

[…] tubular bones with splayed and cupped metaphyses. [abcam.com]

PLSD-T is characterized by varying platyspondyly, short ribs with anterior cupping, hypoplasia of the lower ilia with broad ischial and pubic bones, and shortening of the [abcam.com]

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Rickets

There is cupping and fraying of all of the metaphyses (white arrows) in this skeletally-immature child. For more information, click on the link if you see this icon [learningradiology.com]

[…] coarsened trabecular patterns  widened growth plate with irregular, frayed, and cupped metaphyseal margins (paintbrush metaphyses).  Bowing deformities, fractures, decreased [slideshare.net]

cupping Looser's zones (pseudofracture on the compression side of bone) decreased bone density prominence of rib heads at the osteochondral junction ( rachitic rosary ) bowing [orthobullets.com]

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Ulna Metaphyseal Dysplasia Syndrome

Features include growth plate widening, decreased density, and irregularities in the zone of provisional calcification, metaphyseal cupping and fraying, increased epi-metaphyseal [rrnursingschool.biz]

The cupped metaphyses with pointed edges at birth are another distinctive feature. [czytelniamedyczna.pl]

Shortening of long bones with cupped and widened metaphyses was also noted. [mjdrdypu.org]

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Hypocalcemic Vitamin D-Dependent Rickets

cupping Looser's zones (pseudofracture on the compression side of bone) decreased bone density prominence of rib heads at the osteochondral junction ( rachitic rosary ) bowing [orthobullets.com]

The distal radial and ulnar metaphyses were cup-shaped, and the distal femoral and proximal tibial metaphyses were slightly widened. [pedsinreview.aappublications.org]

Shaft head looks like a cup; Osteo-cartilaginous junction looks fringe, with a vague contour. Chest radiograph y : anterior extremities of the ribs are enlarged. [doctortipster.com]

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Spondyloepimetaphyseal Dysplasia Type Missouri

cupping 0003021 Platyspondyly Flattened vertebrae 0000926 Radial bowing Bowing of outer large bone of the forearm 0002986 Rhizomelia Disproportionately short upper portion [rarediseases.info.nih.gov]

Decreased elbow extension Elbow limited extension Limitation of elbow extension Limited extension at elbows Limited forearm extension Restricted elbow extension [ more ] 0001377 Metaphyseal [rarediseases.info.nih.gov]

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Metaphyseal Anadysplasia

The metaphyses show mild fraying, cupping, and widening [Coarse, frayed, disorganized metaphyses with edge indistinctness] As anticipated above in the section "Metaphyseal [rrnursingschool.biz]

Regression after the age of 10 years Premature fusion of the femoral and tibial epihyses in their metaphyses Cupping metaphyses and cone epiphyses Coronal cleft vertebrae [updoc.site]

Roentgenographic bone changes consisting of splaying, cupping and irregularity of the metaphyses with deep radiolucent metaphyseal defects and bicentric ossification of the [semanticscholar.org]

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Isolated Congenital Sclerocornea

cupping Tracheal stenosis Aplastic anemia Abnormality of the distal phalanx of finger Heart block Abnormality of the pancreas Aplasia/Hypoplasia of the abdominal wall musculature [mendelian.co]

[…] of the hip bone Sporadic Narrow mouth Constipation Agenesis of corpus callosum Syndactyly Heterogeneous Patent ductus arteriosus High palate Pulmonary lymphoma Mesomelia Metaphyseal [mendelian.co]

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Pyosalpinx

In children they include fraying and cupping of metaphyseal regions and in adults, pseudofractures. [orpha.net]

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Primary Immune Deficiency Disorder

These abnormalities include cupping and flaring at the costochondral junctions anteriorly, metaphyseal cupping, and irregularity at the costovertebral junction with increased [ajronline.org]

Reticular dysgenesis is associated with bone anomalies of square shaped scapular tips and cupped costochondral junctions [13]. [symbiosisonlinepublishing.com]

Patients with cartilage-hair hypoplasia have short-limb skeletal dwarfism with metaphyseal dysplasia consisting of sclerosis and cupping (Fig. 13). [ajronline.org]

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