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109 Possible Causes for Metaphyseal Fraying

  • X-Linked Hypophosphatemia

    Diagnostic methods Diagnosis is based on clinical and biochemical findings, and typical rickets/osteomalacia radiographic feautures (in children: fraying and cupping of metaphyseal[]

  • Mohr Syndrome

    Mohr syndrome, one of the numerous forms of oro-facial-digital syndrome (OFDS), is a rare autosomal recessive disorder characterized by specific anomalies of the oral cavity, face, and digits. The diagnosis is clinical and hence a thorough physical exam is essential. Mohr syndrome is the second of at least nine[…][]

  • Schneckenbecken Dysplasia

    […] cupping and fraying of tubular bones have also been observed in Jansen metaphyseal dysplasia (OMIM 156400), which differs by the presence of splayed rib ends and normal alkaline[] […] defects reaching far into the diaphyses (the tubular bones are short and bowed with V-shaped ossification defects at their ends reaching deep into the diaphyses). 10,20 Metaphyseal[]

  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    Three siblings, aged 12, 4 and 2 years, presented at a Gambian clinic with bone deformities. Radiographs of knees and wrists confirmed the presence of florid rickets. The family (including 2 unaffected siblings and the mother) were investigated for hereditary rickets. The three affected siblings had biochemical[…][]

  • Spondyloepimetaphyseal Dysplasia Type SPONASTRIME

    Sponastrime dysplasia is a rare skeletal dysplasia characterized by severe short stature, scoliosis, a saddle nose, frontal bossing, and increased upper/lower segment ratio. Etiology of this condition is unknown. Radiological findings include a concavity in the posterior two thirds of lumbar vertebral bodies,[…][]

  • X-Linked Spondyloepimetaphyseal Dysplasia

    Am J Hum Genet. 2016 Jun 2;98(6):1243-1248. doi: 10.1016/j.ajhg.2016.04.004. Epub 2016 May 26. Cho SY 1, Bae JS 2, Kim NKD 3, Forzano F 4, Girisha KM 5, Baldo C 6, Faravelli F 4, Cho TJ 7, Kim D 8, Lee KY 8, Ikegawa S 9, Shim JS 10, Ko AR 11, Miyake N 12, Nishimura G 13, Superti-Furga A 14, Spranger J 15, Kim OH 16, Park WY 17,[…][]

  • Vitamin D Deficiency

    The radiography of the wrist showed evidence of cupping, fraying, metaphyseal widening, and demineralization of the distal radial and ulnar metaphyses.[] The characteristic finding is of wide growth plates due to poor mineralization, and a frayed appearance at the metaphyseal margin.[]

  • Fracture

    Radiologic changes that should lead to further evaluation for possible deficiency include cupping and fraying of the metaphyses, sickle-shaped metaphyseal spurs, significant[]

  • Hyponatremia

    There were demonstrable improvements in metaphyseal fraying and cupping within 1 month of initiating therapy, followed by almost complete resolution of all metaphyseal abnormalities[] *Radiological findings can include profound hypomineralisation, irregularity of the provisional zone of calcification, physeal widening, metaphyseal flaring/fraying, metaphyseal[] This corresponds to detection of metaphyseal widening, fraying and radiolucencies in the long bones in imaging tests5,11,12 (Fig. 2b).[]

  • Growth Failure

    […] of the metaphyses and a widened epiphyseal plate. 26 Management Nutritional rickets is managed by advice about a balanced diet, correction of predisposing risk factors and[] […] plasma alkaline phosphatase activity greatly increased, 25- hydroxyvitamin D may be low and parathyroid hormone elevated. 3- X-ray of the wrist joint – shows cupping and fraying[]

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