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428 Possible Causes for Metrorrhagia, Mutation in the WWOX Gene

  • Epithelial Ovarian Cancer

    TP53 and PTEN are among the best known tumor suppressor genes involved in EOC pathogenesis, but mutations have also been found in genes OPCML and WWOX, among others.[]

  • Anemia

    INTRODUCTION Table 1 Etiopathogenic classification of anemia. Regenerative anemia Acute or chronic bleeding Hemolytic anemia Hereditary (hemoglobinopathy, enzymopathy, membrane-cytoskeletal defects) Acquired (autoimmune, mechanical destruction, toxic-metabolic, drugs, infectious, PNH, hypersplenism) Hypo-regenerative[…][]

    Missing: Mutation in the WWOX Gene
  • Pregnancy

    Pregnancy in patients with end-stage renal disease is rare, with a paucity of management guidelines in the literature. Various hemodialysis (HD) and peritoneal dialysis (PD) protocols have been used to successfully manage pregnancy in this population; however, there is a growing body of evidence that the best[…][]

    Missing: Mutation in the WWOX Gene
  • Endometriosis

    Some papers have cited endometriosis as one of the leading causes of recurrent minimal metrorrhagia particularly causing post coital bleeding.[]

    Missing: Mutation in the WWOX Gene
  • Uterine Fibroid

    Symptoms and course MYOMA (FIBROIDS) OF THE UTERUS [MUOMA (FIBROMYOMA) UTERI] Mono - and metrorrhagia (polymenorrhea), pain, fluid serous leucorrhoea.[] […] clinical benefit [Figure 3] being the response obtained stable disease, but in concomitance with a worsening of the clinical presentation (the patient experienced a symptomatic metrorrhagia[] […] period and you don’t have to worry about sudden embarrassing heavy bleeding, spotting before period, prolonged menstrual bleeding, intermenstrual bleeding also known as metrorrhagia[]

    Missing: Mutation in the WWOX Gene
  • Hypothyroidism

    Hypothyroidism has multiple etiologies and manifestations. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions. This paper describes evidence-based clinical guidelines for the clinical management of hypothyroidism in ambulatory patients. The development of these[…][]

    Missing: Mutation in the WWOX Gene
  • Coagulation Abnormalities

    We report the case of a 26-year-old woman suffering from borderline personality disorder (BPD), major depression and bulimia nervosa according to DSM-IV who showed unexplained impairment of the vitamin K-dependent coagulation pathway. Subsequently we discuss different manifestations of self damaging behaviour[…][]

    Missing: Mutation in the WWOX Gene
  • Endometrial Polyp

    A 69-year-old woman presented with metrorrhagia. The patient had been diagnosed 4 years before with infiltrating lobular breast carcinoma. Follow-up was uneventful.[] Metrorrhagia was assessed by average days of bleeding per month.[] CONCLUSION: Our results showed that simple polypectomy and more invasive surgical procedures led to subjective improvement in symptoms of menorrhagia and metrorrhagia and[]

    Missing: Mutation in the WWOX Gene
  • Hyperthyroidism

    OBJECTIVE: The treatment of hyperthyroidism associated with severe liver dysfunction (LD) is a clinical challenge, and there has been no unified examination of this problem. The objective of this study was to assess the efficacy and safety of radioiodine ( 131 I) in combination with a molecular adsorbent[…][]

    Missing: Mutation in the WWOX Gene
  • Cervical Cancer

    Postcoital spotting has long been considered a warning sign, but metrorrhagia or menorrhagia may occur as well.[] Establish a history of later symptoms of cervical cancer, including abnormal bleeding or spotting (between periods or after menopause); metrorrhagia (bleeding between normal[]

    Missing: Mutation in the WWOX Gene

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