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2,127 Possible Causes for Microcephaly (2-3 SD), Muscle Hypotonia, Poor Coordination of the Lower Extremity

Did you mean: Microcephaly (2-3 SD, Muscle Hypotonia, Poor Coordination of the Lower Extremity

  • Dysequilibrium Syndrome

    Clinical features include cerebellar ataxia, early-onset cataracts, mild to severe cognitive impairment, hypotonia, and muscle weakness.[ncbi.nlm.nih.gov] Microcephaly (-3 to -4 SD below the mean) has been reported in a few affected individuals. Life span.[ncbi.nlm.nih.gov] Clinical features include severe, progressive neurodegenerative disorder characterized by normal development until age one year, followed by onset of ataxia, muscle hypotonia[ncbi.nlm.nih.gov]

  • Helsmoortel-van der Aa Syndrome

    SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] FEATURES OF WOLF-HIRSCHHORN SYNDROME *Short Philtrum *Immunodeficient *Microcephaly (Small Head Size) *Seizures *Muscle Hypotonia *Renal Anomalies *Deafness 30.[slideshare.net] A common finding in microcephaly is also short stature, typically between -1 SD and -2 SD and in Seckel syndrome it ranges between -4 and -12 SD 3.[centogene.com]

  • Cannabis Abuse

    Abstract Previous neuroimaging studies showed that use of marijuana can alter patterns of cortical activation during rest or a task challenge. We used functional magnetic resonance imaging to examine whether recent cannabis abuse contributed to stress-induced blood-oxygen-level-dependent (BOLD) contrast in a[…][ncbi.nlm.nih.gov]

    Missing: Microcephaly (2-3 SD)
  • Spinocerebellar Ataxia Type 13

    hypotonia.[cerebellumandataxias.biomedcentral.com] SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] Poor Co-ordination- The function of upper and lower extremity muscles are affected, because of lack of normal coordination.[epainassist.com]

    Missing: Microcephaly (2-3 SD)
  • Autosomal Recessive Spinocerebellar Ataxia Type 17

    Hypotonia is a decrease in the normal resistance offered by muscles to passive manipulation When an affected limb is shaken flapping movements of the hands appear of wider[slideshare.net] SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] People with this type of ataxia share many characteristic symptoms including: frequent falls due to poor balance imprecise hand coordination postural or kinetic tremor of[ipfs.io]

    Missing: Microcephaly (2-3 SD)
  • Lissencephaly

    PATHOLOGY AND GENETICS OF MCDs Microcephaly Microcephaly, defined as a head circumference 2-3 SD below the mean, is a condition most frequently associated with subnormal intelligence[neuropathology-web.org] Children who are born with lissencephaly suffer from severe motor impairment, seizures, muscle spasticity, muscle hypotonia, facial abnormalities, difficulty swallowing, abnormalities[disabilitybenefitscenter.org] Infants with ILS may have poor muscle tone (hypotonia) and difficulty feeding, which leads to poor growth overall.[ghr.nlm.nih.gov]

    Missing: Poor Coordination of the Lower Extremity
  • Autosomal Recessive Spinocerebellar Ataxia 18

    SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] Hypotonia is a decrease in the normal resistance offered by muscles to passive manipulation When an affected limb is shaken flapping movements of the hands appear of wider[slideshare.net] Muscle tone • Hypotonia is a typical cerebellar sign. • Wider excursion of hands on shaking the arms. • Obliteration of the space between the volar aspect of the wrist and[slideshare.net]

    Missing: Microcephaly (2-3 SD)
  • Spinocerebellar Ataxia Type 1

    SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] […] twitch 0002380 Gait imbalance Abnormality of balance Abnormality of equilibrium Imbalanced walk [ more ] 0002141 Generalized hypotonia Decreased muscle tone Low muscle tone[rarediseases.info.nih.gov] Symptoms progress to include development of up-gaze palsy, dysdiadochokinesia, and hypotonia.[saintfrancis.com]

    Missing: Microcephaly (2-3 SD)
  • Methylmalonic Aciduria Type cblA

    Mild microcephaly was quite common, but head circumference was not significantly different between subgroups (Kruskal-Wallis rank sum test χ 2 [3] 2.40, p 0.49).[nature.com] hypotonia, hepatomegaly and coma.[orpha.net] Affected infants can experience vomiting, dehydration, weak muscle tone (hypotonia), developmental delay, excessive tiredness (lethargy), an enlarged liver (hepatomegaly),[ghr.nlm.nih.gov]

    Missing: Poor Coordination of the Lower Extremity
  • Kaufman Oculocerebrofacial Syndrome

    Affected individuals have weak muscle tone (hypotonia), and are delayed in developing motor skills such as walking. Intellectual disability is severe or profound.[ghr.nlm.nih.gov] Microcephaly is often moderate with OFC -2 to -3 SD; it is not currently known to worsen with age.[ncbi.nlm.nih.gov] Generalized hypotonia Generalized muscular hypotonia, Decreased muscle tone, Low muscle tone, Hypotonia [more] Generalized muscular hypotonia (abnormally low muscle tone).[rarediseases.oscar.ncsu.edu]

    Missing: Poor Coordination of the Lower Extremity

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