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70 Possible Causes for Microcephaly (2-3 SD), Some Patients Acquire Late Ambulation

Did you mean: Microcephaly (2-3 SD, Some Patients Acquire Late Ambulation

  • Dysequilibrium Syndrome

    Microcephaly (-3 to -4 SD below the mean) has been reported in a few affected individuals. Life span.[ncbi.nlm.nih.gov] Short stature (height just below the 2 nd centile) is a feature in a few affected individuals. Deep tendon reflexes in the lower extremities tend to be brisk.[ncbi.nlm.nih.gov]

  • TORCH Syndrome

    The principal neuroimaging findings in CZS include microcephaly (ie, head circumference 2-3 SD less than mean at a given age), brain parenchymal calcifications (mostly punctate[doi.org] The principal neuroimaging findings in CZS include microcephaly (ie, head circumference 23 SD less than mean at a given age), brain parenchymal calcifications (mostly punctate[ncbi.nlm.nih.gov]

    Missing: Some Patients Acquire Late Ambulation
  • Microcephaly

    […] those with milder microcephaly (-2 to -3 SD; approximately 40%).[ncbi.nlm.nih.gov] A common finding in microcephaly is also short stature, typically between -1 SD and -2 SD and in Seckel syndrome it ranges between -4 and -12 SD 3 .[centogene.com] Children with severe microcephaly (head circumference -3 SD) are more likely ( approximately 80%) to have imaging abnormalities and more severe developmental impairments than[ncbi.nlm.nih.gov]

    Missing: Some Patients Acquire Late Ambulation
  • Vertical Heterotropia

    PATHOLOGY AND GENETICS OF MCDs Microcephaly Microcephaly, defined as a head circumference 2-3 SD below the mean, is a condition most frequently associated with subnormal intelligence[neuropathology-web.org] Acquired (secondary) microcephaly is caused by prenatal or perinatal brain injury due to hypoxic/ischemic insults, congenital infections, and other causes.[neuropathology-web.org]

    Missing: Some Patients Acquire Late Ambulation
  • Carrington Syndrome

    Microcephaly is defined as an occipitofrontal circumference (OFC) of at least 2 or 3 SDs below population norms for age and sex ( 43 ).[pnas.org] Of many possible causes for LB1’s microcephaly, few were systematically investigated. Here we consider DS as a diagnosis for the reasons already stated.[pnas.org]

    Missing: Some Patients Acquire Late Ambulation
  • Amish Lethal Microcephaly

    A common finding in microcephaly is also short stature, typically between -1 SD and -2 SD and in Seckel syndrome it ranges between -4 and -12 SD 3.[centogene.com] Proportional microcephaly occurs when the head circumference is 23 SD below the mean in addition to height and weight being at similar percentiles.[mdpi.com] More severe cognitive impairment has been observed in individuals with Seckel syndrome and in those with isolated microcephaly with brain malformations 3.[centogene.com]

    Missing: Some Patients Acquire Late Ambulation
  • Severe Neonatal-Onset Encephalopathy with Microcephaly

    Discussion Microcephaly is usually defined as an occipitofrontal head circumference (OFC) more than 2 standard deviations (SD) below the mean for sex, age and ethnicity.[pediatriceducation.org] . Incidence of moderate to severe mental retardation  HC from 2-3 SD below the age is 33%.  HC 3 SD, incidence is 62% Not always associated with mental retardation 5.[slideshare.net] Severe microcephaly is used for OFC 3 standard deviations. Rates of microcephaly range from 0.5-12 patients/10,000 live births.[pediatriceducation.org]

    Missing: Some Patients Acquire Late Ambulation
  • Pseudo-Zellweger Syndrome

    PATHOLOGY AND GENETICS OF MCDs Microcephaly Microcephaly, defined as a head circumference 2-3 SD below the mean, is a condition most frequently associated with subnormal intelligence[neuropathology-web.org] Acquired (secondary) microcephaly is caused by prenatal or perinatal brain injury due to hypoxic/ischemic insults, congenital infections, and other causes.[neuropathology-web.org]

    Missing: Some Patients Acquire Late Ambulation
  • Lissencephaly

    PATHOLOGY AND GENETICS OF MCDs Microcephaly Microcephaly, defined as a head circumference 2-3 SD below the mean, is a condition most frequently associated with subnormal intelligence[neuropathology-web.org] Acquired (secondary) microcephaly is caused by prenatal or perinatal brain injury due to hypoxic/ischemic insults, congenital infections, and other causes.[neuropathology-web.org]

    Missing: Some Patients Acquire Late Ambulation
  • Methylmalonic Aciduria Type cblA

    Mild microcephaly was quite common, but head circumference was not significantly different between subgroups (Kruskal-Wallis rank sum test χ 2 [3] 2.40, p 0.49).[nature.com] Again, mut 0 patients (SD 2.2; range, 6.2 to 0.4) were more severely affected than cblB (SD 1.7; range, 4.9 to 1.8), mut (SD 1.05; range, 3.1 to 0.9) and cblA (SD 1.0; range[nature.com]

    Missing: Some Patients Acquire Late Ambulation

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