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599 Possible Causes for Microcytic Anemia, Splenomegaly

  • Thalassemia

    The presence of splenomegaly and the elevation of Hb A(2) and Hb F and the exclusion of a defect of protein of red blood cell (RBC) membranes defined a clinical picture of[ncbi.nlm.nih.gov] On the basis of limited descriptions in the literature, the disease is reported as a mild microcytic anemia with an uncomplicated course.[ncbi.nlm.nih.gov] No splenomegaly was present. Both parents carry sickle cell thalassemia. Table 1, Table 2, and Image 1.[ncbi.nlm.nih.gov]

  • Castleman Disease

    Older age ( 40 years), splenomegaly, and hypoalbuminemia were risk factors for poorer MCD prognosis.[ncbi.nlm.nih.gov] Chronic, iron-refractory, microcytic anemia can be a diagnostic and therapeutic challenge.[ncbi.nlm.nih.gov] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov]

  • Alpha Thalassemia

    Hereditary spherocytosis (HS) is a common inherited hemolytic anemia characterized by heterogeneous clinical presentations with variable degrees of anemia, jaundice, splenomegaly[ncbi.nlm.nih.gov] Two hundred six patients with hypochromic microcytic anemia were evaluated for alpha thalassemia.[ncbi.nlm.nih.gov] Three deletions: Hb H Disease Patients with three alpha-globin deletions display a symptomatic microcytic anemia with moderate extravascular hemolysis that may yield splenomegaly[pathwaymedicine.org]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] anemia of varying degree. [3] Uraninite is a radioactive , uranium-rich mineral and ore with a chemical composition that is largely UO2 , but also contains UO3 and oxides[interhomeopathy.org] MCHC, MCV and RDW aren’t elevated in all anemias…they are different in different anemias.[pathologystudent.com]

  • Cooley's Anemia

    Splenomegaly, episodes of jaundice and roentgenologic evidence of bone involvement were prominent features.[jamanetwork.com] Heterozygous gammabeta(0) mice suffer from microcytic anemia.[ncbi.nlm.nih.gov] —An American Negro male first entered the hospital at the age of 28 months with the clinical findings of dark urine, epistaxis, jaundiced sclerae, splenomegaly, and cardiac[jamanetwork.com]

  • Erythropoietic Protoporphyria

    As hepatic complications worsen the patient will develop splenomegaly, leading to entrapment and hemolysis of erythrocytes.[clinicaladvisor.com] anemia, thrombocytopenia, and mild hepatic dysfunction.[ncbi.nlm.nih.gov] This patient presented cutaneous photosensitivity similar to the heterozygous cases, but a higher protoporphyrin accumulation in erythrocytes, microcytic anemia, and early[ncbi.nlm.nih.gov]

  • Gastrointestinal Hemorrhage

    This is often due to pre-existing liver disease and splenomegaly.[geekymedics.com] anemia, chronic blood loss Protect airway and give high-flow oxygenInsert 2 large-bore (14-16G) IV cannulate take blood for FBC, U&E, LFT, clotting, cross-match 4-6 units[slideshare.net] Other signs to look for are ascites and erythema (chronic liver disease) and splenomegaly and dilated abdominal wall veins (portal hypertension).[uspharmacist.com]

  • Polycythemia Vera

    […] in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] In patients with associated acid-peptic disease, occult gastrointestinal bleeding may lead to presentation with hypochromic, microcytic anemia.[theoncologyinstitute.com] […] efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly[ncbi.nlm.nih.gov]

  • Extramedullary Hematopoiesis

    These findings thus challenge our understanding of splenomegaly as a marker of disease.[ncbi.nlm.nih.gov] Her admission workup showed microcytic anemia.[ncbi.nlm.nih.gov] Medullary expansion of the bony structures with widening of the ribs being the most pronounced bony finding Resorption of trabeculae produces coarsened appearance to bones Splenomegaly[learningradiology.com]

  • Hemoglobin SC Disease

    We report here our experience with an adult patient with severe SC disease who developed symptomatic splenomegaly requiring splenectomy while being treated with hydroxyurea[ncbi.nlm.nih.gov] An 86-year-old black woman admitted for an elective cataract extraction was found to have moderate hypochromic microcytic anemia.[ncbi.nlm.nih.gov] Acute splenic sequestration, a well recognized complication of the various sickle cell syndromes, is characterized by increasing splenomegaly and a sudden fall in hemoglobin[ncbi.nlm.nih.gov]

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