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421 Possible Causes for Microcytic Anemia, Splenomegaly

  • Thalassemia

    Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. .[mayoclinic.org] On the basis of limited descriptions in the literature, the disease is reported as a mild microcytic anemia with an uncomplicated course.[ncbi.nlm.nih.gov] Note : Thalassemia is a microcytic, hypochromic anemia. Its cause is a genetically based decreased synthesis of one or several globin chains.[lecturio.com]

  • Alpha Thalassemia

    BACKGROUND: Hereditary spherocytosis (HS) is a common inherited hemolytic anemia characterized by heterogeneous clinical presentations with variable degrees of anemia, jaundice, splenomegaly[ncbi.nlm.nih.gov] MATERIAL AND METHODS: Two hundred six patients with hypochromic microcytic anemia were evaluated for alpha thalassemia.[ncbi.nlm.nih.gov] Three deletions: Hb H Disease Patients with three alpha-globin deletions display a symptomatic microcytic anemia with moderate extravascular hemolysis that may yield splenomegaly[pathwaymedicine.org]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] anemia of varying degree. [3] Uraninite is a radioactive , uranium-rich mineral and ore with a chemical composition that is largely UO2 , but also contains UO3 and oxides[interhomeopathy.org] MCHC, MCV and RDW aren’t elevated in all anemias…they are different in different anemias.[pathologystudent.com]

  • Castleman Disease

    Older age ( 40 years), splenomegaly, and hypoalbuminemia were risk factors for poorer MCD prognosis. 2017 The Authors.[ncbi.nlm.nih.gov] Abstract Chronic, iron-refractory, microcytic anemia can be a diagnostic and therapeutic challenge.[ncbi.nlm.nih.gov] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov]

  • Cooley's Anemia

    Splenomegaly, episodes of jaundice and roentgenologic evidence of bone involvement were prominent features.[jamanetwork.com] Heterozygous gammabeta(0) mice suffer from microcytic anemia.[ncbi.nlm.nih.gov] —An American Negro male first entered the hospital at the age of 28 months with the clinical findings of dark urine, epistaxis, jaundiced sclerae, splenomegaly, and cardiac[jamanetwork.com]

  • Erythropoietic Protoporphyria

    As hepatic complications worsen the patient will develop splenomegaly, leading to entrapment and hemolysis of erythrocytes.[clinicaladvisor.com] Microcytic anemia occurs in 20% to 60% of patients. We investigated 178 patients with dominant EPP confirmed by molecular analysis.[ncbi.nlm.nih.gov] anemia, thrombocytopenia, and mild hepatic dysfunction.[ncbi.nlm.nih.gov]

  • Gastrointestinal Hemorrhage

    This is often due to pre-existing liver disease and splenomegaly.[geekymedics.com] anemia, chronic blood loss Protect airway and give high-flow oxygenInsert 2 large-bore (14-16G) IV cannulate take blood for FBC, U&E, LFT, clotting, cross-match 4-6 units[slideshare.net] Other signs to look for are ascites and erythema (chronic liver disease) and splenomegaly and dilated abdominal wall veins (portal hypertension).[uspharmacist.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    BACKGROUND: PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com]

  • Severe Congenital Hypochromic Anemia with Ringed Sideroblasts

    This is a rare finding in CDA. 2 Case A full-term male Saudi infant presented after delivery with pallor, splenomegaly (6 cm below left costal margin) and a systolic murmur[annsaudimed.net] MalaCards based summary : Anemia, Hypochromic Microcytic, with Iron Overload 2, is also known as hypochromic microcytic anemia with iron overload 2 .[malacards.org] Lymphadenopathy, splenomegaly. Once case of fatal adrenal hemmorhage. [89] Joints bones muscles cartilage: Hypotonia (generalized or tructal) with increasing severity.[autoinflammatory-search.org]

  • Haemoglobin E Disease

    There were no signs of splenomegaly.[nejm.org] Hb E disease (homozygous Hb E, Hb EE) is also a benign disorder with a mild microcytic anemia (average MCV 62 fl, Hgb 12 g/dl).[path.upmc.edu] Homozygous Hb E disease (a hemoglobinopathy ) causes a mild hemolytic anemia, usually without splenomegaly.[msdmanuals.com]

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