Microcytosis: Causes & Reasons

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Possible Causes for Microcytosis

Hypochromic Microcytic Anemia with Iron Overload Type 2

[…] had an early onset of anemia and splenomegaly (at birth) He had sideroblasts in the bone marrow with occasional ring forms, which is a rare finding in CDA. 2 Absence of microcytosis [annsaudimed.net]

In children, anemia is caused most often by disorders that result in smaller-than-normal RBCs (microcytosis) (Table 1). [pedsinreview.aappublications.org]

Pathology > Basic Hematology > Red Cell Disorders > Sideroblastic Anemia Sideroblastic Anemia Sideroblastic anemias are usually associated with microcytosis and hypochromia [med-ed.virginia.edu]

Mucopolysaccharidosis Type 2

Blood film: Anisopoikilocytosis, microcytosis, hypochromia with pencil cells (showing iron deficiency). SEUC; urea: 20 mg/dl (2.5–6.4 mg/dl). [amhsr.org]

Gaucher Disease

[…] pulmonary symptoms are usually absent.1–3,5 LABORATORY FINDINGS AND MORPHOLOGIC FEATURES The peripheral blood usually shows a moderate to marked anisopoikilocytosis, mild microcytosis [archivesofpathology.org]

Microcytic Anemia

[…] of microcytosis. 1 Enlarge Print Table 4. [aafp.org]

I find microcytosis to be a fascinating and sometimes oversimplified issue. [news.mayomedicallaboratories.com]

Suggested algorithm for diagnosing the cause of microcytosis in adults. [aafp.org]

Mucopolysaccharidosis

Mucopolysaccharidoses (MPS) are lysosomal storage disorders caused by the deficiency of enzymes needed for the stepwise breakdown of glycosaminoglycans (also known as mucopolysaccharides). During the last decades the enzyme deficiencies underlying each disease – as well as the molecular defects causing them –[…] [news-medical.net]

Hemoglobinopathy

We conclude that microcytosis due to thalassemia is common in Ontario and that major forms of thalassemia, including forms predisposing to hemoglobin Bart's hydrops fetalis [ncbi.nlm.nih.gov]

KEYWORDS: Double heterozygosity; HPLC; Hb D-Punjab; Hb Fontainebleau; Hemoglobin variant; Hemoglobinopathy; Microcytosis [ncbi.nlm.nih.gov]

In both patients, a δ-globin mutation was suspected because of an abnormally low Hb A2 level, whereas the α hemoglobinopathy was sought to explain the slight microcytosis [ncbi.nlm.nih.gov]

Thalassemia Minor

Screening classification of cases representing possible thalassemia minor (n = 60) and non-thalassemic microcytosis (n = 60) were studied. [ncbi.nlm.nih.gov]

A diagnosis of thalassemia minor was made when microcytosis persisted after exclusion of iron deficiency or other causes of erythrocyte microcytosis. [ncbi.nlm.nih.gov]

Their blood exhibited marked microcytosis and mild erythrocytosis. Hemoglobin was 99% E and 1% F, 97% E and 3% F, respectively. [ncbi.nlm.nih.gov]

Thalassemia

The microcytosis which is characteristic of all thal, is well compensated for by an increased number of red blood cells. [ci.nii.ac.jp]

Carriers of this mutation have a normal hematologic picture without microcytosis and borderline hemoglobin A2 values, and may be missed during screening. [ncbi.nlm.nih.gov]

In all cases reported so far, patients with HbD-Punjab/β+-thalassemia (IVSI+5 G-C) combination experienced typical thalassemia with hypochromic microcytosis. [ncbi.nlm.nih.gov]

Hemoglobin Bart's Disease

The heterozygous state is asymptomatic but causes microcytosis without anemia. [wikilectures.eu]

They have a mild hemolytic anemia, microcytosis, and target cell formation. [sctpn.net]

Diminished hemoglobinization of individual red cells results in hypochromia and microcytosis. The alpha-globin genes are duplicated on the short arm of chromosome 16. [www1.cgmh.org.tw]

Alpha-Thalassemia

First of all, the degree of microcytosis is not explained by a single alpha gene deletion. [ashclinicalnews.org]

Carriers of alpha0-thalassemia (two deleted alpha-globin genes, ie, alpha-thalassemia trait) show microcytosis, hypochromia, and normal percentages of HbA2 and HbF, carriers [accessmedicine.mhmedical.com]

In addition, Hgb A2 would be expected to be decreased in association with alpha gene deletions sufficient to cause microcytosis. [ashclinicalnews.org]

Beta Thalassemia

Codocytes (target cells) Possible basophilic stippling Nucleated RBCs are usually not present Marked hypochromia and microcytosis Codocytes (target cells) Possible basophilic [labce.com]

First of all, the degree of microcytosis is not explained by a single alpha gene deletion. [ashclinicalnews.org]

However, the analysis carried out in his parents, with increased HBA2 rate and microcytosis concluded in beta-thalassemia trait for father and mother. [ncbi.nlm.nih.gov]

Thalassaemia-Haemoglobin C Disease

A Hb E syndrome should always be considered in a Southeast Asian patient with microcytosis, with or without anemia. [path.upmc.edu]

The father also had Hb-C trait but in addition displayed microcytosis, elevated Hb-F levels and a concentration of Hb-C less than usual for heterozygotes. [ncbi.nlm.nih.gov]

They have a mild hemolytic anemia, microcytosis, and target cell formation. [sctpn.net]

Hemoglobin Lepore-Beta-Thalassemia Syndrome

[…] settings where the test may be helpful Extensive and economical diagnosis and classification of hemoglobinopathies or thalassemia including complex disorders Evaluation of microcytosis [mayomedicallaboratories.com]

[…] and normal hemoglobin electrophoresis for whom more common causes of microcytosis such as iron deficiency and alpha thalassemia have been excluded Testing Algorithm Delineates [mayocliniclabs.com]

The heterozygous state is asymptomatic but causes microcytosis without anemia. [wikilectures.eu]

Hemoglobin E Disease

The heterozygous state is asymptomatic but causes microcytosis without anemia. [wikilectures.eu]

A Hb E syndrome should always be considered in a Southeast Asian patient with microcytosis, with or without anemia. [path.upmc.edu]

Microcytosis on peripheral blood has been described by other authors also. [medresearch.in]

Beta-Thalassemia Associated with Another Hemoglobin Anomaly

First of all, the degree of microcytosis is not explained by a single alpha gene deletion. [ashclinicalnews.org]

Microcytosis and hypochromia were found in every case. Most of the patients were from the North-Western part of Tunisia. [ncbi.nlm.nih.gov]

[…] relative deficiency of one pair of chains and the resultant imbalance of chain pairs result in ineffective production of red blood cells, deficient hemoglobin production, microcytosis [britannica.com]

Hemoglobin E-Thalassemia

A Hb E syndrome should always be considered in a Southeast Asian patient with microcytosis, with or without anemia. [path.upmc.edu]

Adams, J. in: JCI | PubMed | Google Scholar First published July 1, 1981 - More info Abstract Inheritance of the gene for betaE-globin is associated with hypochromia and microcytosis [jci.org]

Such individuals are usually not anemic but may have microcytosis. [web2.iadfw.net]

Hemoglobin D Disease

Hemoglobinopathies can present several clinical symptoms, from benign (mild microcytosis) to the most severe (sickle cell disease, Hb Bart’s hydrops fetalis, …) with multiple [sebia.com]

She had mild anemia with RBC microcytosis, but she did not have hepatosplenomegaly. [ajts.org]

As with our patient, microcytosis is seen in some patients with S/O Arab disease ( 6 ). [clinchem.aaccjnls.org]

Sickle Cell - Hemoglobin E

In heterozygotes (Hb AE), a microcytosis is present without anemia, and target cells can be seen on peripheral blood smear. [merckmanuals.com]

They have a mild hemolytic anemia, microcytosis, and target cell formation. [sctpn.net]

Such individuals are usually not anemic but may have microcytosis. [web2.iadfw.net]

Red Blood Cell Disorder

Hemoglobinemia Hemosiderinuria Hereditary pyropoikilocytosis HFE hereditary haemochromatosis I Iron deficiency L Latent iron deficiency M McLeod syndrome Methemoglobinemia Microcytosis [en.wikipedia.org]

Found with Hypochromic Microcytosis Macrocytosis: abnormally large erythrocytes (i.e., less than 8 in diameter). [medical-labs.net]

Microcytosis (small size) of red blood cell Clinical Information An increase in the number of abnormally shaped red blood cells. [icd10data.com]

Normocytic Normochromic Anemia

Monika Nema 46.  In iron deficiency anemia, hypochromia follows microcytosis.  Whereas in anemia of chronic disease, hypochromia preceeds microcytosis. Dr. [slideshare.net]

Peripheral blood smear shows: Microcytosis and hypochromasia. There is anisocytosis, poikilocytosis. There are pencil cells (elliptical RBCs). [labpedia.net]

Microcytosis….. No anemia MCV decreased 6. Microcytosis without anemia in porto-systemic shunt (PSS) 7. Drugs and chemicals like chloramphenicol or lead toxicity 49. [slideshare.net]

Congenital Heinz Body Hemolytic Anemia

Found with Hypochromic Microcytosis Macrocytosis: abnormally large erythrocytes (i.e., less than 8 in diameter). [medical-labs.net]

Such individuals are usually not anemic but may have microcytosis. [web2.iadfw.net]

Also recall that iron deficiency anemia causes microcytosis, and thus iron deficiency anemia causes hypochromic, microcytic anemia. [theartofmed.wordpress.com]

Congenital Hemolytic Anemia

A child with congenital hemolytic anemia, extreme microcytosis and bizarre red cell morphology has been studied. [ncbi.nlm.nih.gov]

Hypochromia Microcytosis Also, you can have hemolysis Who typically gets beta thalassmias? [cram.com]

A follow up PBS showed microcytosis, anisopoikilocytosis, polychromasia, teardrop cells, fragmented cells and elliptocytes. [casesjournal.biomedcentral.com]

Traumatic Hemolytic Anemia

Peripheral blood smear showed some microcytosis and an increased number of schistocytes. The white cells and platelets were normal. [bloodjournal.org]

Chronic microangiopathic hemolytic anemia may result in iron deficiency anemia with its associated laboratory abnormalities (inappropriate reticulocytosis, microcytosis, and [thebigl.co]

Hemoglobin C Disease

Patients typically had a mild hemolytic anemia characterized by microcytosis and target cells. [ncbi.nlm.nih.gov]

The heterozygous state is asymptomatic but causes microcytosis without anemia. [wikilectures.eu]

Apart from a mild microcytosis, there are no other clinical complications. [clinicaladvisor.com]

Hereditary Sideroblastic Anemia

The blood smear showed marked microcytosis, hypochromia, and poikilocytosis. [nejm.org]

In general, the CSAs that affect heme synthesis result in non-syndromic anemia with small red blood cells (microcytosis), whereas those that affect mitochondrial protein synthesis [danafarberbostonchildrens.org]

Microcytosis is a term used to describe red blood cells that are smaller than normal. [healthline.com]

Sickle Cell - Hemoglobin D

The peripheral blood smear shows microcytosis, target cells and a few pyknotic spherocytes. [wardelab.com]

Possible Condition Clinical Manifestations F only Homozygous beta o -thalassemia Premature Infant Severe thalassemia Repeat screening necessary FE EE E beta o -thalassemia Microcytosis [sickle.bwh.harvard.edu]

The literature reports that the homozygous and heterozygous states of -α 3.7Kb -thal, are characterized by mild anemia, hypochromia and microcytosis. [bmchematol.biomedcentral.com]

Acquired Sideroblastic Anemia

The blood smear showed marked microcytosis, hypochromia, and poikilocytosis. [nejm.org]

Pathology > Basic Hematology > Red Cell Disorders > Sideroblastic Anemia Sideroblastic Anemia Sideroblastic anemias are usually associated with microcytosis and hypochromia [med-ed.virginia.edu]

Methylmalonic Acidemia with Homocystinuria Type cblF

Anemia was defined as hemoglobin <12 g/dL for women and <13 g/dL for men and microcytosis as MCV <80 fL. [tandfonline.com]

In children, anemia is caused most often by disorders that result in smaller-than-normal RBCs (microcytosis) (Table 1). [pedsinreview.aappublications.org]

Microcytosis is a term used to describe red blood cells that are smaller than normal. [healthline.com]

Iron Deficiency

These repeated iron infusions can improve the anemia, microcytosis and iron stores (ferritin). [danafarberbostonchildrens.org]

During stage 4, microcytosis and then hypochromia develop. During stage 5, iron deficiency affects tissues, resulting in symptoms and signs. [merckmanuals.com]

Evaluation of microcytosis. Am Fam Physician. 2010;82(9):1117–1122. 6. Ioannou GN, Spector J, Scott K, Rockey DC. [aafp.org]

Anemia due to Adenosine Triphosphatase Deficiency

All patients with microcytosis had serum ferritin measured. [em-consulte.com]

Both produce asymptomatic hypochromia and microcytosis. In HbH disease, HbA production is only 25–30% normal. [clinicalgate.com]

Serum ferritin was assayed more often in subjects with anemia and microcytosis than the others. [em-consulte.com]