Microcytosis: Causes & Reasons

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Possible Causes for microcytosis

Microcytic Anemia

Anemia occurred in 12% and microcytosis in 21% of these children. The combination of anemia and microcytosis was found in only one of 58 patients (2%). [ncbi.nlm.nih.gov]

Anemia was defined as hemoglobin 12 g/dL for women and 13 g/dL for men and microcytosis as MCV 80 fL. [tandfonline.com]

This reversal of microcytosis with deferoxamine provides objective evidence verifying the toxicity of aluminum, and suggests that microcytosis may be an easily detected marker [ncbi.nlm.nih.gov]

Iron Deficiency

These repeated iron infusions can improve the anemia, microcytosis and iron stores (ferritin). [danafarberbostonchildrens.org]

During stage 4, microcytosis and then hypochromia develop. During stage 5, iron deficiency affects tissues, resulting in symptoms and signs. [merckmanuals.com]

Evaluation of microcytosis. Am Fam Physician. 2010;82(9):1117–1122. 6. Ioannou GN, Spector J, Scott K, Rockey DC. [aafp.org]

Mucopolysaccharidosis Type 2

Blood film: Anisopoikilocytosis, microcytosis, hypochromia with pencil cells (showing iron deficiency). SEUC; urea: 20 mg/dl (2.5–6.4 mg/dl). [amhsr.org]

Mucopolysaccharidosis

Mucopolysaccharidosis type IVB (MPS IVB) is a very rare lysosomal storage disorder characterized by skeletal dysplasia, hearing disorder, and cardiac valvular disease. Herein, we report an extremely rare manifestation of MPS IVB in a 60-year-old female patient who underwent a successful aortic valve replacement. The[…] [ncbi.nlm.nih.gov]

Hemoglobinopathy

We conclude that microcytosis due to thalassemia is common in Ontario and that major forms of thalassemia, including forms predisposing to hemoglobin Bart's hydrops fetalis [ncbi.nlm.nih.gov]

KEYWORDS: Double heterozygosity; HPLC; Hb D-Punjab; Hb Fontainebleau; Hemoglobin variant; Hemoglobinopathy; Microcytosis [ncbi.nlm.nih.gov]

In both patients, a δ-globin mutation was suspected because of an abnormally low Hb A2 level, whereas the α hemoglobinopathy was sought to explain the slight microcytosis [ncbi.nlm.nih.gov]

Hypochromic Microcytic Anemia with Iron Overload Type 2

[…] had an early onset of anemia and splenomegaly (at birth) He had sideroblasts in the bone marrow with occasional ring forms, which is a rare finding in CDA. 2 Absence of microcytosis [annsaudimed.net]

In children, anemia is caused most often by disorders that result in smaller-than-normal RBCs (microcytosis) (Table 1). [pedsinreview.aappublications.org]

Pathology Basic Hematology Red Cell Disorders Sideroblastic Anemia Sideroblastic Anemia Sideroblastic anemias are usually associated with microcytosis and hypochromia and [med-ed.virginia.edu]

Thalassemia

The microcytosis which is characteristic of all thal, is well compensated for by an increased number of red blood cells. [ci.nii.ac.jp]

Carriers of this mutation have a normal hematologic picture without microcytosis and borderline hemoglobin A2 values, and may be missed during screening. [ncbi.nlm.nih.gov]

The presence of an α ⁰ allele should be discarded in individuals with microcytosis without iron deficiency and normal values of Hb A₂ and Hb F with MCH 23.40 pg. [ncbi.nlm.nih.gov]

Thalassemia Minor

Screening classification of cases representing possible thalassemia minor (n 60) and non-thalassemic microcytosis (n 60) were studied. [ncbi.nlm.nih.gov]

A diagnosis of thalassemia minor was made when microcytosis persisted after exclusion of iron deficiency or other causes of erythrocyte microcytosis. [ncbi.nlm.nih.gov]

Their blood exhibited marked microcytosis and mild erythrocytosis. Hemoglobin was 99% E and 1% F, 97% E and 3% F, respectively. [ncbi.nlm.nih.gov]

Anemia

[…] best content from AFP, as identified by the AFP editors, on anemia and related issues, including blood transfusions, iron deficiency and iron supplementation, macrocytosis, microcytosis [aafp.org]

If there are no family antecedents of microcytosis, it is necessary to investigate acquired causes of non-iron deficiency microcytosis, mainly ACD and sideroblastic anemia [dx.doi.org]

Conversely, a normal MCV cannot be taken to rule out those sources typically associated with microcytosis (MCV, 80) or macrocytosis (MCV 100). [cancertherapyadvisor.com]

Beta Thalassemia

Codocytes (target cells) Possible basophilic stippling Nucleated RBCs are usually not present Marked hypochromia and microcytosis Codocytes (target cells) Possible basophilic [labce.com]

First of all, the degree of microcytosis is not explained by a single alpha gene deletion. [ashclinicalnews.org]

However, the analysis carried out in his parents, with increased HBA2 rate and microcytosis concluded in beta-thalassemia trait for father and mother. [ncbi.nlm.nih.gov]

Iron Deficiency Anemia

The vast majority (86.5%) of results indicated microcytosis, yet just more than half (50.8%) of anemic patients received iron therapy. [ncbi.nlm.nih.gov]

When fully manifest, this is characterized by microcytosis (when sufficient microcytic cells are produced) and hypochromaisa. [eclinpath.com]

Normally, a hypochromasia is displayed in the laboratory diagnostics in combination with a microcytosis and a reduced value of serum ferritin ( 15 µg/l). [lecturio.com]

Alpha-Thalassemia

The presence of an α ⁰ allele should be discarded in individuals with microcytosis without iron deficiency and normal values of Hb A₂ and Hb F with MCH 23.40 pg. [ncbi.nlm.nih.gov]

Most silent carriers have only mild microcytosis, which can be differentiated from other common causes of microcytosis on the basis of serum iron and ferritin concentrations [emedicine.medscape.com]

First of all, the degree of microcytosis is not explained by a single alpha gene deletion. [ashclinicalnews.org]

Hemoglobin Lepore-Beta-Thalassemia Syndrome

[…] settings where the test may be helpful Extensive and economical diagnosis and classification of hemoglobinopathies or thalassemia including complex disorders Evaluation of microcytosis [mayomedicallaboratories.com]

Thalassemia and Hemoglobinopathy Ev Useful For Extensive and economical diagnosis and classification of hemoglobinopathies or thalassemia including complex disorders Evaluation of microcytosis [hematology.testcatalog.org]

Such individuals are usually not anemic but may have microcytosis. [web2.iadfw.net]

Hemoglobin Bart's Disease

The heterozygous state is asymptomatic but causes microcytosis without anemia. [wikilectures.eu]

They have a mild hemolytic anemia, microcytosis, and target cell formation. [sctpn.net]

Diminished hemoglobinization of individual red cells results in hypochromia and microcytosis. The alpha-globin genes are duplicated on the short arm of chromosome 16. [www1.cgmh.org.tw]

Hemoglobin E Disease

The heterozygous state is asymptomatic but causes microcytosis without anemia. [wikilectures.eu]

A Hb E syndrome should always be considered in a Southeast Asian patient with microcytosis, with or without anemia. [path.upmc.edu]

In heterozygotes (Hb AE), a microcytosis is present without anemia, and target cells can be seen on peripheral blood smear. [msdmanuals.com]

Hemoglobin E-Thalassemia

A Hb E syndrome should always be considered in a Southeast Asian patient with microcytosis, with or without anemia. [path.upmc.edu]

Such individuals are usually not anemic but may have microcytosis. [web2.iadfw.net]

[…] by Adams, J. in: JCI PubMed Google Scholar First published July 1, 1981 - More info Abstract Inheritance of the gene for betaE-globin is associated with hypochromia and microcytosis [jci.org]

Congenital Hemolytic Anemia

A child with congenital hemolytic anemia, extreme microcytosis and bizarre red cell morphology has been studied. [ncbi.nlm.nih.gov]

Hypochromia Microcytosis Also, you can have hemolysis Who typically gets beta thalassmias? [cram.com]

A follow up PBS showed microcytosis, anisopoikilocytosis, polychromasia, teardrop cells, fragmented cells and elliptocytes. [casesjournal.biomedcentral.com]

Thalassaemia-Haemoglobin C Disease

A Hb E syndrome should always be considered in a Southeast Asian patient with microcytosis, with or without anemia. [path.upmc.edu]

The father also had Hb-C trait but in addition displayed microcytosis, elevated Hb-F levels and a concentration of Hb-C less than usual for heterozygotes. [ncbi.nlm.nih.gov]

They have a mild hemolytic anemia, microcytosis, and target cell formation. [sctpn.net]

Normocytic Normochromic Anemia

Monika Nema 46.  In iron deficiency anemia, hypochromia follows microcytosis.  Whereas in anemia of chronic disease, hypochromia preceeds microcytosis. Dr. [slideshare.net]

Peripheral blood smear shows: Microcytosis and hypochromasia. There is anisocytosis, poikilocytosis. There are pencil cells (elliptical RBCs). [labpedia.net]

Microcytosis….. No anemia MCV decreased 6. Microcytosis without anemia in porto-systemic shunt (PSS) 7. Drugs and chemicals like chloramphenicol or lead toxicity 49. [slideshare.net]

Beta-Thalassemia Associated with Another Hemoglobin Anomaly

First of all, the degree of microcytosis is not explained by a single alpha gene deletion. [ashclinicalnews.org]

Microcytosis and hypochromia were found in every case. Most of the patients were from the North-Western part of Tunisia. [ncbi.nlm.nih.gov]

[…] relative deficiency of one pair of chains and the resultant imbalance of chain pairs result in ineffective production of red blood cells, deficient hemoglobin production, microcytosis [britannica.com]

Hemoglobin D Disease

Hemoglobinopathies can present several clinical symptoms, from benign (mild microcytosis) to the most severe (sickle cell disease, Hb Bart’s hydrops fetalis, …) with multiple [sebia.com]

She had mild anemia with RBC microcytosis, but she did not have hepatosplenomegaly. [ajts.org]

As with our patient, microcytosis is seen in some patients with S/O Arab disease ( 6 ). [clinchem.aaccjnls.org]

Red Blood Cell Disorder

Hemoglobinemia Hemosiderinuria Hereditary pyropoikilocytosis HFE hereditary haemochromatosis I Iron deficiency L Latent iron deficiency M McLeod syndrome Methemoglobinemia Microcytosis [en.wikipedia.org]

Found with Hypochromic Microcytosis Macrocytosis: abnormally large erythrocytes (i.e., less than 8 in diameter). [medical-labs.net]

Microcytosis (small size) of red blood cell Clinical Information An increase in the number of abnormally shaped red blood cells. [icd10data.com]

Traumatic Hemolytic Anemia

Peripheral blood smear showed some microcytosis and an increased number of schistocytes. The white cells and platelets were normal. [bloodjournal.org]

Chronic microangiopathic hemolytic anemia may result in iron deficiency anemia with its associated laboratory abnormalities (inappropriate reticulocytosis, microcytosis, and [thebigl.co]

Vitamin B12 Deficiency

Iron deficiency related microcytosis dominates over B 12 deficiency related macrocytosis if the iron deficiency is more severe than the B 12 deficiency ( e6 ). [ncbi.nlm.nih.gov]

Sickle Cell - Hemoglobin E

In heterozygotes (Hb AE), a microcytosis is present without anemia, and target cells can be seen on peripheral blood smear. [merckmanuals.com]

They have a mild hemolytic anemia, microcytosis, and target cell formation. [sctpn.net]

Such individuals are usually not anemic but may have microcytosis. [web2.iadfw.net]

Megaloblastic Anemia in Pregnancy

Deletion of two genes (alpha thalassaemia trait) causes a more marked microcytosis (MCV 65 – 78) and hypochromia. [bpac.org.nz]

Two hundred women with singleton pregnancies and Hb concentration at booking Results: figures for 110 women (55%) showed microcytosis, hypochromia was observed in 122 (61% [panafrican-med-journal.com]

As a general rule, macrocytosis occurs when there are problems with the synthesis of the blood cells, as in vitamin B12 or folic acid deficiency, whilst microcytosis is associated [patient.info]

Leukoerythroblastic Anemia

Microcytosis: small red cells o. Metamyelocyte: the stage of neutrophil maturation immediately before the band cell. [kerrybrandis.com]

Conversely, a normal MCV cannot be taken to rule out those sources typically associated with microcytosis (MCV, 80) or macrocytosis (MCV 100). [cancertherapyadvisor.com]

Microcytosis suggests iron deficiency anemia. [ascopost.com]

Congenital Heinz Body Hemolytic Anemia

Found with Hypochromic Microcytosis Macrocytosis: abnormally large erythrocytes (i.e., less than 8 in diameter). [medical-labs.net]

Such individuals are usually not anemic but may have microcytosis. [web2.iadfw.net]

Also recall that iron deficiency anemia causes microcytosis, and thus iron deficiency anemia causes hypochromic, microcytic anemia. [theartofmed.wordpress.com]

Hemoglobin C Disease

Patients typically had a mild hemolytic anemia characterized by microcytosis and target cells. [ncbi.nlm.nih.gov]

As with our patient, microcytosis is seen in some patients with S/O Arab disease ( 6 ). [clinchem.aaccjnls.org]

The heterozygous state is asymptomatic but causes microcytosis without anemia. [wikilectures.eu]

Hereditary Sideroblastic Anemia

The blood smear showed marked microcytosis, hypochromia, and poikilocytosis. [nejm.org]

Microcytosis is a term used to describe red blood cells that are smaller than normal. [healthline.com]

In general, the CSAs that affect heme synthesis result in non-syndromic anemia with small red blood cells (microcytosis), whereas those that affect mitochondrial protein synthesis [danafarberbostonchildrens.org]