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23 Possible Causes for Microphallus, Small Testicular Volume

  • Hypogonadotropic Hypogonadism

    The twins manifested with microphallus, cryptorchidism, and deficient postnatal activation of the hypothalamic-pituitary-gonadal axis, findings consistent with IHH.[ncbi.nlm.nih.gov] Cryptorchid or maldescended testes and small testicular volume are clinical hallmarks of congenital hypogonadotropic hypogonadism (CHH) [ 1 ].[ijpeonline.biomedcentral.com] As a result, he had a full-skin exam and was found to have a microphallus, undescended testes, and minimal pubic hair distribution. He had a normal sense of smell.[omicsonline.org]

  • Anorchia

    Physical examination may reveal microphallus or normal external male genitalia with bilateral or unilateral palpable intrascrotal or inguinal masses or no palpable masses.[symptoma.com] Testicles are “born” small and grow in size during puberty and later adulthood before losing some volume in later age.[drelist.com] Family members of 7/26 cases had histories of primary ovarian failure in the mother (n   2), or sister 46,XX, together with fetal malformations of the only boy with microphallus[ncbi.nlm.nih.gov]

  • Kallmann Syndrome Type 4

    A large proportion of these subjects report a history of cryptorchidism (40%) or microphallus (20%) (46).[78stepshealth.us] Cryptorchid or maldescended testes and small testicular volume are clinical hallmarks of congenital hypogonadotropic hypogonadism (CHH) [ 1 ].[ijpeonline.biomedcentral.com] Mean testicular volumes of HH patients were measured at the time of the diagnosis (solid circles) and at participation in the current study (small line).[journals.plos.org]

  • Hypogonadism

    Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[msdmanuals.com] […] testes – volume typically 3 Lack of secondary sexual characteristics Most common cause is Klinefelter syndrome Postpubertal hypogonadism Sexual – decreased libido, erectile[arupconsult.com] Second- or 3rd-trimester onset of testosterone deficiency results in microphallus and undescended testes.[msdmanuals.com]

  • Kallmann Syndrome Type 3

    As a result, he had a full-skin exam and was found to have a microphallus, undescended testes, and minimal pubic hair distribution. He had a normal sense of smell.[omicsonline.org] Mean testicular volumes of HH patients were measured at the time of the diagnosis (solid circles) and at participation in the current study (small line).[journals.plos.org] Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[msdmanuals.com]

  • Hypogonadotropic Hypogonadism Type 18

    As a result, he had a full-skin exam and was found to have a microphallus, undescended testes, and minimal pubic hair distribution. He had a normal sense of smell.[omicsonline.org] The clinical phenotype of our patients mirrored the severity of their hormonal deficiency with small prepubertal testicular volume and underdeveloped external genitalia.[journals.plos.org] Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[merckmanuals.com]

  • Hypogonadotropic Hypogonadism Type 8

    As a result, he had a full-skin exam and was found to have a microphallus, undescended testes, and minimal pubic hair distribution. He had a normal sense of smell.[omicsonline.org] When the deficit is more severe and testicular volume is very small, FSH must be added [ 1 ].[em-consulte.com] […] syncope) or neurologic manifestations (eg, color blindness, hearing deficit, epilepsy, paraplegia). [28] Absent or incomplete puberty Some male patients may present with microphallus[emedicine.medscape.com]

  • Klinefelter Syndrome

    Beyond single case reports, data are not available for 48,XXXY; however, microphallus is described in case reports, ( 10 ) and it is predicted that mean phallus length would[ncbi.nlm.nih.gov] They concluded that the decline in serum testosterone may be related to the small testicular volume and Leydig cell loss near the scars after the procedures.[web.archive.org] The treatment of men with Klinefelter syndrome has been thought to be limited by the small testicular volume, extensive tubular sclerosis, and high FSH typically found for[dx.doi.org]

  • XXXXY Syndrome

    A two month-old boy with intrauterine growth restriction (IUGR) and low birth weight, facial dysmorphism, clinodactyly in feet, microphallus, and right undescendent testis[ncbi.nlm.nih.gov] Testicular volume is typically less than 10 ml in postpubertal 47,XXY individuals [ 5 ].[doi.org] […] multiple congenital anomalies including microcephaly, facial dysmorphism (hypertelorism, megacornea, cleft palate, and micrognathia), obvious heart murmur, umbilical hernia, microphallus[ncbi.nlm.nih.gov]

  • Hypogonadotropic Hypogonadism Type 21

    Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[merckmanuals.com] Cryptorchid or maldescended testes and small testicular volume are clinical hallmarks of congenital hypogonadotropic hypogonadism (CHH) [ 1 ].[ijpeonline.biomedcentral.com] Low testicular volume (indicated by small testicles) is a key indicator of both primary testicular failure and secondary hypogonadism.[myvmc.com]

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