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104 Possible Causes for microtubule, pole to pole

  • Paclitaxel

    Microtubule dynamics assays revealed that DPT destabilized microtubule assembly in a different mode.[ncbi.nlm.nih.gov] Once the two kinetochores of a sister-chromatid pair attach to microtubules from the opposite poles, they congress to the center of the cells ( Cleveland et al., 2003 ).[doi.org] Many new drugs that target microtubules are in clinical trials and large numbers of microtubule-active compounds are being developed.[doi.org]

  • Griseofulvin

    At or near half-maximal proliferation inhibitory concentration, griseofulvin dampened the dynamicity of microtubules in MCF-7 cells without significantly disrupting the microtubule[ncbi.nlm.nih.gov] Almost all spindle poles in cells with multipolar spindles contained two centrin signals, clearly indicating that each spindle pole consists of a complete centrosome ( Fig[cancerres.aacrjournals.org] microtubules.[doi.org]

  • TUBB2B-Related Polymicrogyria

    Using in vitro biochemical assays and yeast genetics, we find that TUBB2B-E421K αβ-heterodimers are incorporated into the microtubule network where they alter microtubule[scholar.harvard.edu] Parasagittal ( a ) and axial ( b ) T1-weighted images show coarse polymicrogyria extending from the frontal pole to the occipital pole Fig. 7 Grade 2 perisylvian PMG.[link.springer.com] Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus[sinobiological.com]

  • MRX100

    KIF4 protein has the property of nucleotide-dependent binding to microtubules, microtubule-activated ATPase activity, and microtubule plus-end-directed motility.[doi.org] Poleward and away from the pole forces balance each other during metaphase congression and are responsible for chromosome motility toward the poles ( Marshall, 2002 ).[doi.org] Microtubule‐associated proteins . J Cell Biol 160 : 517 – 528 Schuyler SC , Pellman D ( 2001 ) Microtubule ‘plus‐end‐tracking proteins’: the end is just the beginning .[doi.org]

  • Frontotemporal Dementia

    The vast majority of these mutations map to the C-terminal region of tau possessing microtubule assembly and microtubule dynamics regulatory activities as well as the ability[ncbi.nlm.nih.gov] (Brodmann areas 10 and 11), temporal pole (Brodmann area 38) and the hypothalamus, but not in the nucleus basalis of Meynert, in comparison with controls.[dx.doi.org] The presence of microtubule-associated-protein-tau-based pathological features in some patients and the discovery, in some familial cases, of mutations in the tau gene links[ncbi.nlm.nih.gov]

  • Autosomal Recessive Primary Microcephaly

    The dgt41 mutant shows an early embryo lethality with severe microtubule-organizational defects, including a lack of microtubules attached to kinetochores.[diginole.lib.fsu.edu] […] and to focus the poles of the mitotic spindles during mitosis and meiosis [ 81 , 82 ].[ncbi.nlm.nih.gov] […] orientation of mitotic spindles, 2) chromosome condensation mechanism during embryonic neurogenesis, 3) DNA damage-response signaling, 4) transcriptional regulations and microtubule[ncbi.nlm.nih.gov]

  • Autosomal Recessive Primary Microcephaly 4

    The dgt41 mutant shows an early embryo lethality with severe microtubule-organizational defects, including a lack of microtubules attached to kinetochores.[diginole.lib.fsu.edu] Centrosomes occupy a position at the spindle pole during mitosis, and the centrosomes are transmitted to the daughter cells by means of their attachment to spindle poles.[cruk.cam.ac.uk] microtubule organization from the centrosome, organism-specific biosystem In addition to recruiting proteins and complexes necessary for increased microtubule nucleation,[ncbi.nlm.nih.gov]

  • Polymicrogyria

    Abstract Microtubules are essential components of axon guidance machinery.[ncbi.nlm.nih.gov] Parasagittal ( a ) and axial ( b ) T1-weighted images show coarse polymicrogyria extending from the frontal pole to the occipital pole Fig. 7 Grade 2 perisylvian PMG.[doi.org] […] and microtubule-associated proteins.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Spastic Paraplegia Type 10

    Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS Keywords - Cellular component i Cytoplasm , Cytoskeleton , Microtubule[uniprot.org] , PTEN, RINT1, RNF43, RPS20, SCG5, SMAD4, STK11, TP53 Sindromes tumorales Sindromes de poliposis (14 genes, CAN11) APC, BMPR1A, CHEK2, GREM1, MSH3, MUTYH, NTHL1, POLD1, POLE[web.gencellpharma.com] Wood JD, Landers JA, Bingley M, et al. (2006) The microtubule‐severing protein spastin is essential for axon outgrowth in the zebrafish embryo.[els.net]

  • Congenital Fibrosis of Extraocular Muscles

    "Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance". Cell. 140 : 74–87. doi : 10.1016/j.cell.2009.12.011. PMC 3164117.[en.wikipedia.org] The pole sutures are moved laterally, and then two further single throws are created on the opposite side of the pole sutures.[cybersight.org] Descartes M, Flaherty M, Jamieson RV, Moller HU, Meuthen I, Callen DF, Kerwin J, Lindsay S, Meindl A, Gupta ML Jr, Pellman D, Engle EC Title Human TUBB3 mutations perturb microtubule[genome.jp]

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