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113 Possible Causes for Midbrain Atrophy

  • Classic Progressive Supranuclear Palsy Syndrome

    MRI features include 1-4 : midbrain atrophy midbrain to pons area ratio (figure 1): reduced area ratio on the midline sagittal plane to approximately 0.12 (normal 0.24) 4.[radiopaedia.org] ), and higher for global atrophy of midbrain (16 of 52 cases).[ajnr.org] Midbrain atrophy on conventional MRI correlates with the clinical phenotype of RS but is not predictive of PSP pathology.[ingentaconnect.com]

  • Progressive Supranuclear Palsy

    This fact has important implications for the limitation of midbrain atrophy as a diagnostic imaging biomarker of PSP pathology.[ncbi.nlm.nih.gov] Atrophy of pons with preservation of midbrain. Atrophy of both pons and midbrain. Atrophy of midbrain with preservation of pons. Atrophy of whole of brain stem.[doi.org] MRI features include 1-4 : midbrain atrophy midbrain to pons area ratio (figure 1): reduced area ratio on the midline sagittal plane to approximately 0.12 (normal 0.24) 4.[radiopaedia.org]

  • Alzheimer Disease

    Aβ42 may be particularly abundant in the cerebral cortex, hippocampus, cerebellum, midbrain, and basal ganglia. Prominent cerebral amyloid angiopathy has also been seen.[alzforum.org] Neuropathology Those affected by the E280A mutation show neuropathology consistent with a diagnosis of AD, including severe brain atrophy, Aβ pathology, and hyperphosphorylated[alzforum.org]

  • Meningitis

    In AIDS patients there is often cortical atrophy and there may be coexistent pathology.[dx.doi.org] MRI scans are more sensitive for detection of multiple enhancing nodules within the brain parenchyma, meninges, basal ganglia and midbrain.[dx.doi.org]

  • Pseudobulbar Palsy

    ), and higher for global atrophy of midbrain (16 of 52 cases).[ajnr.org] Indeed, some degree of midbrain atrophy may also be present in PD.[ajnr.org] We found a significant correlation between alterations in the superior midbrain profile and global atrophy of the midbrain.[ajnr.org]

  • Vascular Dementia

    Pathological Findings In Vascular Dementia Macroscopy Atrophy (cortical and/or subcortical) Ventricular dilatation Infarcts (usually in large vessel territories, multiple,[web.archive.org] Other strategic locations include the frontal white matter or base of the forebrain, basal ganglia, genu of the internal capsule, hippocampus, mamillary bodies, and the midbrain[web.archive.org]

  • Multi-Infarct Dementia

    Pathological Findings In Vascular Dementia Macroscopy Atrophy (cortical and/or subcortical) Ventricular dilatation Infarcts (usually in large vessel territories, multiple,[web.archive.org] Other strategic locations include the frontal white matter or base of the forebrain, basal ganglia, genu of the internal capsule, hippocampus, mamillary bodies, and the midbrain[web.archive.org]

  • Perry Syndrome

    atrophy, predominant nonmotor symptoms responsive to levodopa, distinctive craniocervical levodopa induced dyskinesias, and a good response to high-dose levodopa therapy[ncbi.nlm.nih.gov] The proband displayed a series of distinctive features not previously described in Perry syndrome: a disorder of vertical downward saccades accompanied by progressive midbrain[ncbi.nlm.nih.gov]

  • Shy Drager Syndrome

    Focal midbrain atrophy, involving particularly the upper part of the quadrigeminal plate, was obvious in five cases.[ncbi.nlm.nih.gov] Putaminal involvement and vermian cerebellar atrophy are significantly most common in MSA, but cortical atrophy, midbrain atrophy, and third ventricle enlargement are most[emedicine.medscape.com] […] example, if MRI shows characteristic changes in the midbrain, pons, or cerebellum.[merckmanuals.com]

  • Olivopontocerebellar Atrophy

    In contrast, patients with severe atrophy revealed by the midbrain ratio had significantly lengthened RT and MT performances compared to those with mild-moderate atrophy assessed[ncbi.nlm.nih.gov] Statistically significant atrophy of pons, brachium pontis, cerebellum and midbrain was noted in patient group.[ncbi.nlm.nih.gov] Abstract We described cytoplasmic inclusions in glial cells in 18 patients with olivopontocerebellar atrophy (OPCA) (multiple system atrophy, MSA).[ncbi.nlm.nih.gov]

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