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1,122 Possible Causes for Midline Defects

  • Lethal Midline Granuloma

    One of the causes of such defects is midline lethal granuloma, which is a destructive granulomatous lesion of uncertain aetiology, involving the nose, paranasal sinuses and[ncbi.nlm.nih.gov] These midfacial defects lead to functional and cosmetic deficiencies.[ncbi.nlm.nih.gov] Prosthetic rehabilitation of the midfacial defects has always perplexed maxillofacial prosthodontists.[ncbi.nlm.nih.gov]

  • Mitochondrial Neurogastrointestinal Encephalomyopathy Type 4B

    […] cleft of lower lip Midline defects autosomal type Midline defects recessive type Midline developmental field defects Midline field defects Midline lethal granuloma Midphalangeal[diseaseinfosearch.org] […] impairment, and cleft palate Microtia, meatal atresia and conductive deafness Microtia-Anotia Microvillus inclusion disease Middle ear infection Middle East respiratory syndrome Midline[diseaseinfosearch.org]

  • Nephrogenic Diabetes Insipidus

    Common causes of central DI include intra-ventricular hemorrhage, congenital infection and midline defects.[casereports.in] However, CDI in infants is rare, and has been associated to intraventricular hemorrhage, congenital infection, midline defects and septo-optic dysplasia [ 4 ].[casereports.in]

  • Short Rib-Polydactyly Syndrome Type Beemer-Langer

    Two additional abnormalities are present, namely hypo- thalamic hamartoma and a midline defect in the occipi- tal bone which have not been reported in Beemer- Langer syndrome[docslide.com.br] . • The brain may be normal or altered by agenesis of the corpus callosum , cerebral dysgenesis, porencephaly , or midline cerebral and cerebellar defects. • Research has[medlink.com] This defect need not be taken as specific for the hydrolethalus syndrome and may represent a defect in ossification.[docslide.com.br]

  • Trisomy 18

    Craniofacial malformations are common congenital defects caused by failed midline inductive signals.[ncbi.nlm.nih.gov] The major midline dysmorphic features of trisomy 13 are due to a defect in the fusion of the midline prechordial mesoderm in the first three weeks of gestation.[pedclerk.bsd.uchicago.edu] […] arteriosus, a defect of the lower sternum, a midline supraumbilical abdominal wall defect with omphalocele, congenital left posterior diaphragmatic hernia (Bochdalek hernia[ncbi.nlm.nih.gov]

  • Vitreoretinal Degeneration

    Wagner's vitreoretinal degeneration, midline facial defects and a moderate generalized epiphyseal dysplasia defined radiologically were encountered in a boy and his father[ncbi.nlm.nih.gov] The presence of a congenital midline scalp defect should alert the clinician to possible underlying central nervous system and/or ocular pathology and should lead to consideration[ncbi.nlm.nih.gov] Data from these families imply that congenital occipital scalp defects rather than true encephaloceles may, as is true in some cases of Meckel syndrome, accompany Knobloch[ncbi.nlm.nih.gov]

  • Polyhydramnios

    Opitz G/BBB syndrome is a congenital disorder characterized by midline defects, such as hypertelorism, cleft lip and/or palate, hypospadias, and by dysphagia often caused[ncbi.nlm.nih.gov]

  • Low-Grade Astrocytoma

    We report on a child with midline facial defects with hypertelorism (MFDH), median cleft lip, sphenoidal ventriculocele, partial agenesis of the corpus callosum, and low-grade[ncbi.nlm.nih.gov]

  • Panhypopituitarism

    These data demonstrate that homozygous HESX1 mutation causing an R160H substitution can result in panhypopituitarism without midline defects.[ncbi.nlm.nih.gov] We report on a neonate with unexplained heart failure and minor physical anomalies, suggesting a midline defect. She was diagnosed with complete CPHD.[ncbi.nlm.nih.gov] Children with congenital midline defects or optic atrophy (which suggests the presence of septo-optic dysplasia) and boys with micropenis due to deficit gonadotropin hormones[symptoma.com]

  • Beckwith-Wiedemann Syndrome

    Beckwith-Wiedemann syndrome (BWS) is a rare congenital syndrome characterized by gigantism, macroglossia, exophthalmos, postpartum hypoglycemia, and multiple midline defects[ncbi.nlm.nih.gov] […] the association between BWS and midline defects.[pediatrics.aappublications.org] BWS is characterized by large body size, enlarged organs, macroglossia (enlarged tongue), midline abdominal wall defects (omphalocele/exomphalos, umblicial hernia, diastasis[howbigbws.com]

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