Create issue ticket

644 Possible Causes for Midline Defects, Pediatric Disorder

  • Septo-Optic Dysplasia

    BACKGROUND: Septo-optic dysplasia, a variable combination of abnormalities of cerebral midline structures, is a clinically heterogeneous syndrome in which the midline defects[] Neurological Disorders and Stroke www.ninds.nih.bov/health_and_medical/disorders/septo-optic.html References in primary literature [ edit ] Hellstrom A, et al.[] It may also be accompanied by other malformations, including multiple facial dysmorphism, midline defects, cleft lip and palate, musculoskeletal and other non-neurological[]

  • Frontonasal Dysplasia

    Abstract Frontonasal dysplasia (FND) is a congenital malformation characterized by hypertelorism, broad nasion with a midline cleft in the bony dorsum, midline defect of the[] Radiology of syndromes and metabolic disorders. Pediatric Surgery. 2 nd ed. Chicago, IL: Year Book Medical; 1983. p. 235. [Figure 1] [Table 1][] Surgical intervention is often required for midline facial defects 9.[]

  • Kallmann Syndrome

    Abstract Kallmann syndrome (isolated hypogonadotropic hypogonadism) is associated with a number of midline defects, especially anosmia.[] Michael Freemark , Obesity and the Endocrine System, Part I: Pathogenesis of Weight Gain in Endocrine and Metabolic Disorders , Pediatric Obesity , 10.1007/978-3-319-68192[] PATIENT CONCERNS: Developmental disorders with olfactory abnormalities, developmental lag, heart malformations, external genital malformations.[]

  • Wolf Hirschhorn Syndrome

    Characteristics include marked prenatal and postnatal growth retardation with psychomotor delay, profound mental deficiency, distinctive facies, and midline defects.[] Abstract Wolf-Hirschhorn syndrome (WHS) is a complex genetic disorder caused by the loss of genomic material from the short arm of chromosome 4.[] defects, urinary tract malformations and brain, hearing and ophthalmologic malformations.[]

  • Patau Syndrome

    The major midline dysmorphic features of trisomy 13 are due to a defect in the fusion of the midline prechordial mesoderm in the first three weeks of gestation.[] Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 81. Madan-Khetapal S, Arnold G. Genetic disorders and dysmorphic conditions.[] Pediatr Dermatol. 2010 Mar-Apr;27(2):199-200. doi: 10.1111/j.1525-1470.2010.01098.x.[]

  • Atrial Septal Defect

    Surgical atrial septal defect treatment is performed by an open heart surgery, done using an up-and-down (vertical) incision in the midline of the chest.[] Alex Thompson, Dawn Hackman and Larry Burd , Mortality in Fetal Alcohol Spectrum Disorders , Open Journal of Pediatrics , 04 , 01 , (21) , (2014) .[]

  • Coxa Vara

    […] in membranous ossification is reflected by the clinical involvement of mostly midline structures notably cranium, spine and pubic symphysis. 2,4-6 Cranial and facial features[] Abstract Developmental coxa vara (DCV) is a well-known pediatric hip disorder that is associated with triplanar deformity of the proximal femur.[] D Resnick: Diagnosis of Bone and Joint Disorders Vol V, Saunders 1995, ISBN 0-7216-5071-6 External links [ edit ][]

  • Subdural Hematoma

    A narrow elongated defect, or so-called slot fracture, sometimes is produced by a stab wound and is diagnostic when identified.[] Headache is the most common symptom of MTBI. 4 Possible causes include posttraumatic migraine, tension headache, exacerbation of a preexisting headache disorder, analgesic[] […] of a young female who presented to the emergency department with a stab wound to the head produced by a large knife shows the extent of intracranial damage, which affects midline[]

  • Congenital Optic Disc Coloboma

    Pituitary stalk duplication in association with moya disease and bilateral morning glory disc anomaly - broadening the clinical spectrum of midline defects.[] Accompanying ocular disorders may include aniridia, albinism, coloboma, Duane retraction syndrome, high myopia, and numerous neurological and pediatric conditions.[] Scientific articles pertaining to specific disorders are scattered throughout medical subspecialty journals.[]

  • Neonatal Hypoglycemia

    Over 1/3 had structural lesions of the hypothalamic-pituitary area or midline facial defects.[] Pediatrics. 2011;127:575–9. PubMed CrossRef Google Scholar 38. Cook P, Walker V. Investigation of the child with an acute metabolic disorder.[] Pediatrics 1990;85:834-837. Cornblath M, Schwartz R. Disorders of Carbohydrate Metabolism in Infancy. 3rd ed. Philadelphia: W.B. Saunders, 1991, pp. 87-124, 225-246.[]

Further symptoms