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133 Possible Causes for Midline Defects, Systolic Murmur

  • Scoliosis

    Abstract Cantrell's pentalogy (CP) is a rare syndrome characterized by defects in the lower sternum with ectopia cordis, anterior diaphragm defects, midline supraumbilical[] The location is defined by the vertebra that is most deviated and rotated from midline, called the apical vertebra.[] […] abdominal wall defects, defects in the diaphragmatic pericardium, and congenital heart disease.[]

  • Atrial Septal Defect

    Surgical atrial septal defect treatment is performed by an open heart surgery, done using an up-and-down (vertical) incision in the midline of the chest.[] murmur but did not clearly show the presence of fixed splitting of S2.[] Clinically, the patient had typical features of PE with chest computed tomography (CT) revealing a Haller index of 4.4 and a grade 2 systolic murmur being heard the loudest[]

  • Mitral Valve Prolapse

    Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum Mol Genet. 2006; 15 :2457–2467. [ PubMed ] [ Google Scholar ] 10.[] Scattered creptus was audible over mid and lower lung fields and a soft systolic murmur was auscultated at apex.[] […] skeletal defects in mice lacking filamin A, Hum Mol Genet, 2006 , vol. 15 (pg. 2457 - 2467 ) 10 Periostin regulates collagen fibrillogenesis and the biomechanical properties[]

  • Ventricular Septal Defect

    Objective:: Perventricular device closure of ventricular septal defect through midline sternotomy avoids the cardiopulmonary bypass, however, lacks the cosmetic advantage.[] An 32-months-old boy was admitted for a significant precordial systolic murmur.[] Most VSDs can be noticed by systolic murmur even today.[]

  • Endocardial Cushion Defect

    Echocardiography Allows direct visualization of the defect spectrum and often a large defect of the midline heart structures are seen.[] A cleft in the left AV valve results in a blowing apical systolic murmur of mitral regurgitation.[] Ectopia cordis results from the failure of migration of lateral mesoderm into the midline.[]

  • Funnel Chest

    We performed concomitant repair of pectus excavatum and an atrial septal defect through a short midline incision in an adult [5].[] In one series, systolic murmurs were auscultated in 46% of cases not associated with an underlying connective tissue disorder. [5] The prevalence of murmurs was independent[] […] cardiac murmur is sometimes heard and mitral valve prolapse is found in as many as 25% of patients. 4, 5, 31 The percentage of pectus patients with mitral valve prolapse[]

  • Pentalogy of Cantrell

    SYNDROME; THAS Cantrell pentalogy Thoraco-abdominal syndrome Midline Defects, X-Linked Cantrell syndrome THAS Cantrell deformity Cantrell Haller Ravitsch syndrome Statements[] On physical examination her vital signs were within normal limit, she had a systolic murmur on heart at lower left sternal area and there was a vascular structure present[] He was not tachypneic or tachycardic and had first and second heart sounds with a systolic murmur. Bowel sounds were audible and normal.[]

  • Lutembacher Syndrome

    Autosomal dominant secundum atrial septal defect with various cardiac and noncardiac defects: a new midline disorder.[] In addition, systolic murmurs at the left parasternal area can be heard on the grounds of increased pulmonary valve flow, holosystolic murmurs increasing during respiration[] Systolic murmurs: A pulmonary flow murmur due to increased flow across the pulmonic valve. Tricuspid regurgitation: lower left parasternal area.[]

  • Atrial Septal Defect 9

    Keywords Atrial septal defect. Thoracotomy. Direct cannulation.[] Murmurs • Pulmonary ejection systolic murmur – Increased pulmonary flow • Tricuspid murmur – is heard over left sternal edge louder on inspiration • Graham-Steell murmur[] Typical clinical findings consisted of loud first heart sound, widely fixed split second heart sound and soft ejection systolic murmur at the upper left sternal border were[]

  • Panhypopituitarism

    CONCLUSION: These data demonstrate that homozygous HESX1 mutation causing an R160H substitution can result in panhypopituitarism without midline defects.[] The systolic murmur with severity 2/6 was heard in LSB (left sternal border). At the lower extremities non-pitting edema was evident in both legs.[] We report on a neonate with unexplained heart failure and minor physical anomalies, suggesting a midline defect. She was diagnosed with complete CPHD.[]

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