Mild Cognitive Decline: Causes & Reasons

Possible Causes for Mild Cognitive Decline

[…] ataxia (SCA21) OMIM #607454 Mild ataxia Cognitive delay Extrapyramidal features Hyporeflexia -- 7p21-p15.1 Spinocerebellar ataxia (SCA22) Gradual onset, slow progression [emedicine.medscape.com]

decline Myoclonus tremor -- 1p21-q21 Spinocerebellar ataxia (SCA20) OMIM #608687 Dysarthria Dystonia Calcification of dentate nucleus Palatal tremor -- 11p13-q11 Spinocerebellar [emedicine.medscape.com]

Spinocerebellar ataxia (SCA18) OMIM #607458 Ataxia Sensorimotor neuropathy -- 7q22-q32 Spinocerebellar ataxia (SCA19) OMIM #607346 Slowly progressive ataxia Hyporeflexia Cognitive [emedicine.medscape.com]

Unverricht-Lundborg Syndrome

cognitive decline over time. [orpha.net]

cognitive decline. [diseases.jensenlab.org]

(ULD) is a rare progressive myoclonic epilepsy disorder characterized by action- and stimulus-sensitive myoclonus, and tonic-clonic seizures with ataxia, but with only a mild [orpha.net]

Progressive Myoclonic Epilepsy Type 7

Learning disability prior to seizure onset and mild cognitive decline may be associated. [orpha.net]

Adult Polyglucosan Body Disease

As the disease progressed, mild cognitive decline may have affected up to half of the patients. [research.vu.nl]

TAU Syndrome

Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of Alzheimer type. Arch Neurol 66(5):638-645, 2009. Anderson, H. [labtestsonline.it]

Nicergoline Poisoning

[…] functioning and awareness in subjective cognitive decline, mild cognitive impairment, and very mild Alzheimer disease SY Ryu, A Kim, SY Kim, KW Park, KH Park, YC Youn, DW [scholar.google.co.kr]

[…] dizziness (PPPD): a SPECT study S Na, JJ Im, H Jeong, ES Lee, TK Lee, YA Chung, IU Song Journal of Neural Transmission 126 (2), 123-129, 2019 102019Self‐and informant‐reported cognitive [scholar.google.co.kr]

Autosomal Recessive Spastic Paraplegia Type 44

Early cognitive development is normal but mild cognitive decline appears eventually. Pes cavus and scoliosis may occur. [disorders.eyes.arizona.edu]

cognitive decline, cataracts, and thin corpus callosum on brain imaging. [30] SPG47 614066 AP4B1 1p13.2 Autosomal recessive Formerly called cerebral palsy – spastic quadriplegic [psychology.wikia.com]

Brain imaging can show thinning of the corpus callosum, with mild cerebellar and cerebral atrophy. [disorders.eyes.arizona.edu]

Autosomal Recessive Spastic Paraplegia Type 35

cognitive decline associated with leukodystrophy on brain imaging. [ncbi.nlm.nih.gov]

[…] recessive spastic paraplegia-35 is a complicated form of SPG characterized by childhood onset of gait difficulties due to progressive spastic paraparesis, dysarthria, and mild [ncbi.nlm.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 20

Early cognitive development is normal but mild cognitive decline appears eventually. Pes cavus and scoliosis may occur. [disorders.eyes.arizona.edu]

Brain imaging can show thinning of the corpus callosum, with mild cerebellar and cerebral atrophy. [disorders.eyes.arizona.edu]

Autosomal Recessive Spastic Paraplegia Type 46

Early cognitive development is normal but mild cognitive decline appears eventually. Pes cavus and scoliosis may occur. [disorders.eyes.arizona.edu]

Brain imaging can show thinning of the corpus callosum, with mild cerebellar and cerebral atrophy. [disorders.eyes.arizona.edu]

Autosomal Dominant Spastic Paraplegia Type 4

decline in cognitive function. [rarediseases.info.nih.gov]

(hyperreflexia) Ankle spasms High arches in the feet (pes cavus) Reduced bladder control Ataxia (lack of muscle control) Seizures Some individuals may also experience a mild [rarediseases.info.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 23

cognitive decline, extrapyramidal features, optic atrophy and seizures. [monarchinitiative.org]

[…] lower limb (followed by upper limb) spasticity with hyperreflexia and extensor plantar responses, with additional manifestations including progressive dysarthria, dystonia, mild [monarchinitiative.org]

Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

Other common features include ataxia (58%), spasticity (57%), recurrent seizures (49%), and mild cognitive decline. [1], [4] Seizures are usually well controlled with antiepileptics [annalsofian.org]

cognitive decline (summary by Lopez-Hernandez et al., 2011 ). [mendelian.co]

Subcortical Dementia

AD – STAGESStage 3: Mild cognitive decline (early-stage Alzheimers can be diagnosed in some,but not all, individuals with these symptoms)Friends, family or co-workers begin [slideshare.net]

DIFFERENTIAL DIAGNOSIS  DELIRIUM  MILD COGNITIVE IMPAIRMENT (MCI)  AGE-RELATED COGNITIVE DECLINE  MENTAL RETARDATION  SCHIZOPHRENIA  DEPRESSION  FACTITIOUS D/O  ALCOHOL [slideshare.net]

Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment. [researchsquare.com]

Autosomal Recessive Spastic Paraplegia Type 21

Early cognitive development is normal but mild cognitive decline appears eventually. Pes cavus and scoliosis may occur. [disorders.eyes.arizona.edu]

Brain imaging can show thinning of the corpus callosum, with mild cerebellar and cerebral atrophy. [disorders.eyes.arizona.edu]

Anaplastic Oligoastrocytoma

[…] deficit a 11 18 11 19 Severe deficit b 17 27 17 30 N/A 7 11 – – a Defined as: Mild neuro deficit and/or mild cognitive decline. b Defined as: Severe neurologic deficit and [academic.oup.com]

No is defined as no or disabled or retired. b Only included patients with known information at both time points. c Where mild is mild neurologic deficit and/or mild cognitive [academic.oup.com]

decline. [academic.oup.com]

Alzheimer Disease

Beginning at age 89 years, very mild cognitive and functional decline reported by his collateral source resulted in a diagnosis of very mild dementia of the Alzheimer type [ncbi.nlm.nih.gov]

Elevated saturated fatty acids could have negative effects on age-related cognitive decline and mild cognitive impairment (MCI). [ncbi.nlm.nih.gov]

Progressive Myoclonic Epilepsy Type 3

Patient 8 experienced a mild cognitive decline in his early 20s, a few years before his death. [academic.oup.com]

Cognitive decline is slow and sometimes mild. Patients typically do not live beyond middle-age, but there are exceptions. [en.wikipedia.org]

Patient 5a was noted to have mild cognitive decline in the last year of her life, whereas her brother, Patient 5b had no cognitive dysfunction at age 28 years, the year prior [academic.oup.com]

Vascular Dementia

Stage 3 The last stage in this category is stage 3, mild cognitive decline. [leisurecare.com]

This model consists of the following 7 stages: Stage 1: No Impairment – No memory loss Stage 2: Very Mild Cognitive Decline – Normal memory loss associated with aging Stage [kindlycare.com]

More recently, some physicians use the term "vascular cognitive impairment," perhaps because it seems to capture the wide range (from mild to severe) of cognitive decline [alzheimers.about.com]

Dementia

N/A No Dementia Stage 2: Very Mild Cognitive Decline This stage is used to describe normal forgetfulness associated with aging. [dementiacarecentral.com]

Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage on the continuum of cognitive decline, characterized by objective impairment in cognition that [doi.org]

Unknown No Dementia Stage 3: Mild Cognitive Decline This stage includes increased forgetfulness, slight difficulty concentrating, and decreased work performance. [dementiacarecentral.com]

Familial Cerebral Cavernous Malformation

Mild cognitive decline with memory deficits has also developed. [nejm.org]

Mild cognitive decline with memory deficits has also developed. Ithamar Ganmore, M.D., Ph.D. Anat Achiron, M.D., Ph.D. [nejm.org]

Pilotto Syndrome

Cumulative epidemiological evidence suggested that vascular and vascular-related factors may be important for the development of agerelated cognitive decline (ARCD), mild [eurekaselect.com]

Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis. [neuroscience-aachen.de]

cognitive impairment (MCI), and cognitive decline of degenerative (Alzheimers disease, AD) or vascular origin (vascular dementia, VaD). [eurekaselect.com]

Organic Brain Syndrome

[…] to moderate cognitive decline of the organic brain syndrome, statistically significant effects could be detected after eight weeks (on the EEG), and after 12 weeks of treatment [ncbi.nlm.nih.gov]

Stage 3: Mild cognitive decline no dementia This stage includes increased forgetfulness, slight difficulty concentrating and some decreased work performance. [emedicinehealth.com]

This subjective cognitive decline is associated with an increased risk of progression to mild cognitive impairment (MCI) and dementia (Jessen et al., 2014). [asha.org]

Spastic Paraplegia - Precocious Puberty

Early cognitive development is normal but mild cognitive decline appears eventually. Pes cavus and scoliosis may occur. [disorders.eyes.arizona.edu]

Brain imaging can show thinning of the corpus callosum, with mild cerebellar and cerebral atrophy. [disorders.eyes.arizona.edu]

Autosomal Recessive Spastic Paraplegia Type 63

613162 SPG45 10q24.3–q25.11 Autosomal recessive SPG46 614409 SPG46 9p21.2–q21.12 Autosomal recessive Childhood onset, slowly progressive, associated with cerebellar signs, mild [psychology.wikia.com]

Cerebral Cortical Atrophy

[…] of cognitive decline in patients with MCI. [sciencedaily.com]

decline not only in patients diagnosed with Alzheimer’s but also in individuals with mild cognitive impairment or those who are cognitively normal but are at risk for Alzheimer [massgeneral.org]

Brain atrophy in Parkinson's disease correlates with cognitive decline, which worsens with the degree of tissue shrinkage. [medpagetoday.com]

Alcohol Dementia

Stages of Alzheimer's disease include no cognitive impairment, mild cognitive decline, moderate cognitive decline, moderately severe cognitive decline... [neurology.health-cares.net]

Bottom Line: This observational study examined alcohol consumption and the risk of dementia and cognitive decline in older adults with or without mild cognitive impairment [eurekalert.org]

In the abstract, researchers found that participants with mild cognitive impairment "had a greater decline in time out of home over time compared to cognitively intact patients [cnn.com]

Spastic Paraplegia - Glaucoma - Intellectual Disability

Early cognitive development is normal but mild cognitive decline appears eventually. Pes cavus and scoliosis may occur. [disorders.eyes.arizona.edu]

Brain imaging can show thinning of the corpus callosum, with mild cerebellar and cerebral atrophy. [disorders.eyes.arizona.edu]

Autosomal Dominant Spastic Paraplegia Type 29

decline in cognitive function. [rarediseases.info.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 27