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1,549 Possible Causes for Mild Cognitive Impairment, Percussion Myotonia, Variation in Fiber Size Seen on Muscle Biopsy

  • Oculo-Pharyngo-Distal Myopathy

    myotonia: delayed relaxation following percussion of the thenar eminence Grip myotonia: delayed relaxation of firm handshake Reflexes depressed Gait: high steppage (foot[evidencereviewed.com] Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment.[ncl.ac.uk] It always follows muscle activation (action myotonia), usually voluntary, but may be elicited by mechanical stimulation (percussion myotonia) of the muscle.[clinicalgate.com]

  • Myotonic Dystrophy

    Percussion myotonia or myotonia of grasp or both is usually present if looked for.[pediatrics.aappublications.org] Specifically, the regional distribution and neuropsychologic correlates of NFTs and amyloid plaques in cognitively normal elderly subjects and in persons with mild cognitive[doi.org] In addition to muscle problems, issues with respiratory function, heart abnormalities, cataracts, cognitive impairment and personality abnormalities are often seen.[web.archive.org]

    Missing: Variation in Fiber Size Seen on Muscle Biopsy
  • Paramyotonia Congenita

    They experience neither grip nor percussion myotonia during warm weather, whereas myotonia is provoked by cold. Her younger son has no symptoms.[ncbi.nlm.nih.gov] cognitive impairments 17 ; more severe intellectual disability is more common with younger onset of clinical disease.[now.aapmr.org] Also of diagnostic importance are the myotonic reactions inducible at room temperature, such as percussion myotonia, active myotonia and paradoxical myotonia.[ncbi.nlm.nih.gov]

    Missing: Variation in Fiber Size Seen on Muscle Biopsy
  • Generalized Myotonia of Thomsen

    On examination he showed percussion myotonia. There was no grip myotonia or eyelid myotonia. Nerve conduction studies were normal.[jnnp.bmj.com] Spasticity, dystonia, tremor and migraine were variably present; cognitive impairment was severe in early childhood cases, but was absent in adults.[jnnp.bmj.com] Secondary outcomes: (1) clinical relaxation time; (2) electromyographic relaxation time; (3) stair test; (4) presence of percussion myotonia; and (5) adverse events.[cochrane.org]

    Missing: Variation in Fiber Size Seen on Muscle Biopsy
  • Acute Alcohol Intoxication

    Acute alcohol intoxication refers to the development of severe and possibly life-threatening complications after ingestion of large amounts of alcohol. Symptoms range from changes in behavior to severe hypothermia, vomiting, altered consciousness, coma, and respiratory insufficiency that may be fatal. A detailed[…][symptoma.com]

    Missing: Percussion Myotonia Variation in Fiber Size Seen on Muscle Biopsy
  • Hypoglycemia

    Some diabetes medications increase the risk of hypoglycemia, as can inadequate nutrition, cognitive impairment, and other factors.[ncbi.nlm.nih.gov] Abstract Hypoglycemic events range from mild to severe and occur at an increased rate among older adults with diabetes.[ncbi.nlm.nih.gov]

    Missing: Percussion Myotonia Variation in Fiber Size Seen on Muscle Biopsy
  • Alzheimer Disease

    The first cohort included 49 older controls and 48 individuals with mild cognitive impairment, while the second cohort included 94 older controls and 57 mild cognitive impairment[ncbi.nlm.nih.gov] Recent research has identified a transitional state between the cognitive changes of normal aging and Alzheimer's disease (AD), known as mild cognitive impairment (MCI).[ncbi.nlm.nih.gov] Mild cognitive impairment (MCI) manifests as memory impairment in the absence of dementia and progresses to Alzheimer's disease (AD) at a rate of around 15% per annum, versus[ncbi.nlm.nih.gov]

    Missing: Percussion Myotonia Variation in Fiber Size Seen on Muscle Biopsy
  • Chronic Alcoholism

    […] associated impairment in emotional processes and social cognition.[ncbi.nlm.nih.gov] After some six months of abstinence, the mild cortical atrophy and impaired cognition often associated with alcoholism disappear.[britannica.com] Chronic excessive alcohol consumption is associated with cognitive deficits, ranging from mild to severe, in executive functions, memory, and metacognitive abilities, with[ncbi.nlm.nih.gov]

    Missing: Percussion Myotonia Variation in Fiber Size Seen on Muscle Biopsy
  • Hyponatremia

    Abstract Hyponatremia is the most common electrolyte disorder and also a predictor of mild cognition impairment.[ncbi.nlm.nih.gov] cognition impairment.[journals.plos.org] OBJECTIVE: The study objective was to determine the eventual consequences (falls, unsteadiness, and cognitive impairment) of mild chronic hyponatremia, which is generally[ncbi.nlm.nih.gov]

    Missing: Percussion Myotonia Variation in Fiber Size Seen on Muscle Biopsy
  • Brain Concussion

    […] an earlier age of onset in people with mild cognitive impairment and Alzheimer’s disease.[alz.org] Cognitive impairment following closed head injury. Neurol Clin. 1992 Nov. 10(4):879-93. [Medline]. McCrea M, Guskiewicz KM, Marshall SW, et al.[emedicine.medscape.com] These results were consistent with other studies that indicate traumatic brain injury is a significant risk factor for cognitive decline in older adults and associated with[alz.org]

    Missing: Percussion Myotonia Variation in Fiber Size Seen on Muscle Biopsy

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