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243 Possible Causes for Mild Distal Muscle Weakness

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2J

    An autosomal recessive degenerative myopathy (OMIM:608807) characterised by progressive weakness of the pelvic and shoulder girdle muscles. Severe disability occurs within two decades of onset. Molecular pathology Defects of TTN, which encodes a critical protein in striated muscle, cause limb-girdle muscular[…][medical-dictionary.thefreedictionary.com]

  • Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org] He had mild weakness of distal leg muscles and disturbed sensation of heat and pain below ankles, mildly impaired sensation of touch in his legs with preserved vibration sense[petit.lib.yamaguchi-u.ac.jp] In the early stages of peripheral neuropathy, patients typically present with progressive symptoms, including sensory loss, numbness, and pain or burning sensations in distal[aafp.org]

  • Peripheral Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org] In the early stages of peripheral neuropathy, patients typically present with progressive symptoms, including sensory loss, numbness, and pain or burning sensations in distal[aafp.org]

  • Polyneuropathy

    On motor examination, mild distal weakness was observed in 38 patients (41%) and distal muscle atrophy was observed in 14 (15%).[jamanetwork.com]

  • Sepsis

    In addition, muscle weakness—a muscular disability rating score (MDRS) of 1 was no deficit; 2, minimal deficit or atrophy; 3, mild to moderate distal deficit; 4, mild to moderate[jama.ama-assn.org]

  • X-linked Parkinsonism-Spasticity Syndrome

    There are occasional reports of mild distal muscle atrophy but more marked involvement of the upper limbs with spasticity, weakness, or amyotrophy is not usually seen in pure[jnnp.bmj.com]

  • Muscular Dystrophy

    Distal myopathies. These are very rare forms of muscle weakness affecting the distal muscles, which are those of the hands and feet. There are different types.[patient.info] Most are very mild. How is muscular dystrophy treated? There is no cure for MD, although there are treatments which can help.[patient.info]

  • Septicemia

    In addition, muscle weakness—a muscular disability rating score (MDRS) of 1 was no deficit; 2, minimal deficit or atrophy; 3, mild to moderate distal deficit; 4, mild to moderate[jama.ama-assn.org]

  • Lafora Disease

    Weakness Symmetric Proximal Distal: 1 patient with only hand weakness Specific muscles involved Neck flexion Shoulder abduction: May be asymmetric Elbow flexion & extension[neuromuscular.wustl.edu] weakness more improved than proximal Better pulmonary function Some muscles remain weak Late onset: Mild improvement or disease stabilization reported Course after treatment[neuromuscular.wustl.edu] Abdominal muscles Foot dorsiflexion Scapular winging : Mild; May be asymmetric Respiratory: Mild Face & Eyes: Normal Course: Slow progression Cardiomyopathy: Some patients[neuromuscular.wustl.edu]

  • Paraneoplastic Syndrome

    ; Legs Arms; Symmetric Sensory: Panmodal sensory loss; Paresthesias Weakness: Distal & Proximal with sparing of intermediate muscles Mild distal weakness 2 axonal neuropathy[neuromuscular.wustl.edu] […] disorders of nerve muscle : Common 15% weight loss, or Late disease: Nearly 100% Polyneuropathy : Distal, Symmetric, Sensory Motor; Axonal Myopathy : Proximal 2 Type II muscle[neuromuscular.wustl.edu] […] than neoplasm Paraneoplastic syndromes indicate evaluation for neoplasm Associations : Several paraneoplastic syndromes may be related to one type of neoplasm Incidence Mild[neuromuscular.wustl.edu]

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