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30 Possible Causes for Mild Distal Sensory Axonal Neuropathy

  • Vasculitis

    Rituxan Neuropathy with IgG or polyclonal IgM binding to Sulfatide Clinical Features Sensory Symmetric; Paraesthesias Distal; Hands & feet Motor loss: Mild or absent Electrophysiology[neuromuscular.wustl.edu] Axonal loss Serum Autoantibody: IgM or IgG vs Sulfatide Serum M-Protein : Occasional Treatment: Cyclophosphamide & Plasma exchange Polyneuropathy & IgM anti-sulfatide antibodies[neuromuscular.wustl.edu]

  • Paraneoplastic Syndrome

    ; Legs Arms; Symmetric Sensory: Panmodal sensory loss; Paresthesias Weakness: Distal & Proximal with sparing of intermediate muscles Mild distal weakness 2 axonal neuropathy[neuromuscular.wustl.edu] : Less prominent than sensory change Proximal weakness 2 type II muscle fiber atrophy Progression Slow Occurs later in course of disease: Rare at neoplasm onset Severity:[neuromuscular.wustl.edu] Clinical 5% of patients with cancer: More common later in disease course than at onset 100% with weight loss 15% Electrophysiological change: 30% to 40% Clinical Distribution: Distal[neuromuscular.wustl.edu]

  • Distal Hereditary Motor Neuropathy Type 1

    Charcot-Marie-Tooth hereditary neuropathy type 2 (CMT2) is a non-demyelinating (axonal) peripheral neuropathy characterized by distal muscle weakness and atrophy, mild sensory[bcbst.com]

  • CANOMAD Syndrome

    Rituxan Neuropathy with IgG or polyclonal IgM binding to Sulfatide Clinical Features Sensory Symmetric; Paraesthesias Distal; Hands & feet Motor loss: Mild or absent Electrophysiology[neuromuscular.wustl.edu] Axonal loss Serum Autoantibody: IgM or IgG vs Sulfatide Serum M-Protein : Occasional Treatment: Cyclophosphamide & Plasma exchange Polyneuropathy & IgM anti-sulfatide antibodies[neuromuscular.wustl.edu]

  • Arachnoiditis

    Neuropathy Onset: Acute Clinical Symmetric Distal Legs Arms Course: Mild or no improvement Electrophysiology: Axon loss Nerve pathology: Axon loss Associated syndrome: Rhabdomyolysis[neuromuscular.wustl.edu] Onset: Pain; Allodynia Weakness: Distribution Lumbosacral or Brachial Proximal Single extremity Asymmetric Course Persistent proximal weakness Pain resolution over months Sensory-Motor[neuromuscular.wustl.edu]

  • Cerebellar Neoplasm

    ; Legs Arms; Symmetric Sensory: Panmodal sensory loss; Paresthesias Weakness: Distal & Proximal with sparing of intermediate muscles Mild distal weakness 2 axonal neuropathy[neuromuscular.wustl.edu] : Less prominent than sensory change Proximal weakness 2 type II muscle fiber atrophy Progression Slow Occurs later in course of disease: Rare at neoplasm onset Severity:[neuromuscular.wustl.edu] Clinical 5% of patients with cancer: More common later in disease course than at onset 100% with weight loss 15% Electrophysiological change: 30% to 40% Clinical Distribution: Distal[neuromuscular.wustl.edu]

  • Monoclonal Gammapathy

    These patients with A-MGUS had a relatively homogenous clinical presentation with modest sensory symptoms—distal leg numbness, paraesthesiae, and mild imbalance—with pain[jnnp.bmj.com] […] had primarily axonal disease.[jnnp.bmj.com] […] almost 20% of patients in their series with chronic axonal neuropathy had MGUS. 22 Our experience was similar in that we found that 44% of a consecutive series with MGUS and neuropathy[jnnp.bmj.com]

  • Hereditary Sensory Neuropathy

    All patients had a relatively mild progressive distal sensory impairment, with onset after age 50.[ncbi.nlm.nih.gov] Sural biopsy revealed a severe chronic axonal neuropathy with subtotal loss of myelinated axons, relatively preserved number of non-myelinated fibers and no signs for regeneration[ncbi.nlm.nih.gov]

  • Charcot-Marie-Tooth Disease Type 2S

    […] a peripheral sensorimotor neuropathy, characterized by distal legs sensory loss and weakness that can be asymmetric.[ebi.ac.uk] OLS Orphanet Rare Disease Ontolog ORDO Orphanet:228174 Autosomal dominant Charcot-Marie-Tooth disease type 2N (CMT2N) is a mild form of axonal Charcot-Marie-Tooth disease,[ebi.ac.uk]

  • Hereditary Motor and Sensory Neuropathy

    Charcot-Marie-Tooth hereditary neuropathy type 2 (CMT2) is a non-demyelinating (axonal) peripheral neuropathy characterized by distal muscle weakness and atrophy, mild sensory[bcbst.com]

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