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10 Possible Causes for Mild Global Cerebral Atrophy

  • Hypomyelinating Leukodystrophy Type 9
  • Glutaric Aciduria Type 2

    After 5 months, mild developmental delay was noted and the cerebral MRI displayed a global increase of atrophy and bilateral cytotoxic edema posteromedially in the lentiform[pediatrics.aappublications.org]

  • Canavan Disease

    […] cerebellar atrophy, mild cerebral atrophy and symmetric hyperintensity of the periventricular white matter (images d, e, h and i are reprinted with permission from Poretti[ncbi.nlm.nih.gov] , Coronal and i, Axial T2-weighted images of a 3.5-year-old child with late-infantile neuronal ceroid lipofuscinoses, ataxia and myoclonic seizures demonstrates moderate global[ncbi.nlm.nih.gov]

  • Sea-blue histiocytosis

    Magnetic resonance imaging (MRI) of the brain showed global diffuse cerebral and mild cerebellar atrophy [Figure 1].[neurologyindia.com] Figure 1: Magnetic resonance imaging of the brain showing global diffuse cerebral and mild cerebellar atrophy Click here to view Our second patient was a 23-year-old unmarried[neurologyindia.com] Ultrasonography of the whole abdomen revealed mild splenomegaly.[neurologyindia.com]

  • Fragile X-Associated Tremor - Ataxia Syndrome

    […] parkinsonism, (2) has the middle cerebellar peduncle (MCP) sign, global cerebellar and cerebral atrophy, and/or subcortical white matter lesions on MRI, or (3) has a family[ncbi.nlm.nih.gov] […] and testing for the Fragile X mental retardation 1 (FMR1) gene premutation if a patient over the age of 50 (1) presents with cerebellar ataxia and/or intention tremor with mild[ncbi.nlm.nih.gov]

  • Hyperphosphatasia with Mental Retardation Syndrome 3

    atrophy ; Cleft palate ; Congenital onset ; Elevated alkaline phosphatase ; Generalized hypotonia ; Global developmental delay ; Hyperphosphatemia ; Intellectual disability[mousephenotype.org] , mild ; Intellectual disability, severe ; Microcephaly ; Seizures ; Short nose ; Tented upper lip vermilion ; Wide nasal bridge Associated Genes PGAP2 (Withdrawn symbols:[mousephenotype.org] RECESSIVE 21; MRT21 Classification bone, developmental, genetic, metabolism, neurological Phenotypes Absent speech ; Autosomal recessive inheritance ; Broad nasal tip ; Cerebral[mousephenotype.org]

  • Cerebellar Atrophy

    […] cortex and cerebellar vermis atrophy with mild cerebellar hemisphere atrophy, associated with profound global developmental delay.[orpha.net] […] central nervous system malformation syndrome characterized by congenital, progressive microcephaly, neonatal to infancy-onset of severe, intractable seizures, and diffuse cerebral[orpha.net]

  • Cataract - Ataxia - Short Stature - Mental Retardation (CASM)

    cerebral atrophy, mild (in some patients) MISCELLANEOUS: Onset in the first year of life; Variable severity; Four patients from 3 families have been reported (last curated[findzebra.com] Dysmetria; Dysarthria; Extrapyramidal syndrome; Poor or absent independent walking; Hyperreflexia; Intention tremor; Brain imaging shows hypomyelination; Thin corpus callosum; Global[findzebra.com] […] visual fixation (1 patient) MUSCLE, SOFT TISSUE: Hypertonicity of the lower limbs NEUROLOGIC: [Central nervous system]; Delayed psychomotor development; Mental retardation, mild[findzebra.com]

  • Alopecia - Hypogonadism - Extrapyramidal Syndrome

    atrophy Scoliosis Amyotrophic lateral sclerosis Global developmental delay Areflexia Intellectual disability, mild Obsessive-compulsive behavior Abnormality of mitochondrial[mendelian.co] […] metabolism Olivopontocerebellar atrophy Pontocerebellar atrophy Fasciculations Abnormal cerebellum morphology Cerebral palsy Incoordination Postural tremor Hyperactive deep[mendelian.co] Anxiety Postural instability Muscle weakness Peripheral neuropathy Horizontal nystagmus Autosomal recessive inheritance Truncal ataxia Limb ataxia Progressive Myoclonus Cerebral[mendelian.co]

  • Weakness of Orbicularis Oculi Muscles

    […] developmental delay Hypertelorism Abnormality of the skeletal system Delayed skeletal maturation Inguinal hernia Cerebral atrophy Behavioral abnormality Malar flattening[mendelian.co] […] differentiation Non-Hodgkin lymphoma Mucosal telangiectasiae Decreased proportion of CD4-positive T cells Aplasia/Hypoplasia of the thymus Immunoglobulin IgG2 deficiency Global[mendelian.co] Kyphosis Intellectual disability, mild Hydrocephalus Depressed nasal bridge Intellectual disability, severe Ventriculomegaly Frontal bossing Short neck Macrocephaly Hyperreflexia[mendelian.co]

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