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447 Possible Causes for Mild Proximal Muscle Weakness, Onset of Symptoms in the Fourth to Sixth Decade of Life

  • Charcot-Marie-Tooth Disease Type 2S

    Clinical and electrophysiological data Limbs Onset of peripheral neuropathic symptoms was between the fourth and the sixth decades of life in five out of the seven patients[jnnp.bmj.com] […] investigated; the two remaining patients (II.2 and III.1) showed an earlier onset, with lightning pains as first symptom.[jnnp.bmj.com]

  • Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Peripheral Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Restless Legs Syndrome

    Although one third of patients are affected before the age of 20 years, clinical presentation typically occurs between the fourth and sixth decades of life, when sensory symptoms[content.nejm.org] […] of disease, sensory symptoms are mild and punctuated by asymptomatic periods of variable duration.[content.nejm.org] […] age-dependent expressivity; the influences of anemia, uremia, diabetes, and peripheral neuropathy; and possibly the modulation of phenotype by body iron stores. 18 At the onset[content.nejm.org]

    Missing: Mild Proximal Muscle Weakness
  • Interstitial Lung Disease

    He presented with progressive dyspnoea and weight loss, later developing dysphagia, mild proximal muscle weakness and mild sicca symptoms.[ncbi.nlm.nih.gov] Examination showed mild proximal muscle weakness and bi-basal crackles. She was admitted and extended myositis screen was sent.[ncbi.nlm.nih.gov] She was started on hydroxychloroquine. 4 weeks later on follow-up, she developed proximal muscle pain, dysphagia, dyspnea and dry cough.[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Central Core Disease

    On neurological examination, he had mild proximal muscle weakness and atrophy, decreased deep tendon reflexes and Gowers' sign, but his intelligence was normal.[ncbi.nlm.nih.gov] muscle weakness.[invitae.com] Most people with central core disease experience persistent, mild muscle weakness that does not worsen with time.[mhaus.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Cardiomyopathy

    weakness (60%) Proximal Slowly progressive Mild Other organ systems: Variable Ears External: Thick; Small; Malformed Deafness CNS: Mental retardation Eyes Movement: Strabismus[neuromuscular.wustl.edu] […] cytoplasmic lipid droplets Clinical features Onset Age: Birth Collodion babies Ichthyosiform erythroderma: Fine white scales; Erythematous background; All over body Hepatomegaly Muscle[neuromuscular.wustl.edu]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Sepsis

    In addition, muscle weakness—a muscular disability rating score (MDRS) of 1 was no deficit; 2, minimal deficit or atrophy; 3, mild to moderate distal deficit; 4, mild to moderate[jama.ama-assn.org] proximal deficit; and 5, severe proximal deficit or atrophy 19 —was recorded at study entry and at days 7, 14, 21, 28, or up to ICU discharge (depending on which occurred[jama.ama-assn.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Atrial Standstill

    Persistent atrial standstill (PAS) is a rare disorder characterized by absence of atrial activity on the surface and intracavity electrograms, absence of atrial mechanical activity, and inability to electrically stimulate the atria. Four patients (ages 18-60 years) with PAS were evaluated. One of these (no. 3) only[…][ncbi.nlm.nih.gov]

    Missing: Mild Proximal Muscle Weakness
  • Carcinoma of the Prostate

    The patient had oral candidiasis, thin skin, multiple petechiae on the chest, a small supraclavicular fat pad and proximal muscle weakness.[ec.bioscientifica.com] On examination, the patient was hypertensive (BP 154/74 mmHg), euphoric and grossly oedematous with bilateral pitting oedema to the mid-shins and mild facial oedema.[ec.bioscientifica.com]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life

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