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17 Possible Causes for Mild to Moderate Hyperkeratosis, Orthokeratosis

  • Pityriasis Rubra Pilaris

    Histopathology showed mild to moderate hyperkeratosis with focal parakeratosis and hypergranulosis.[] Microscopically follicular plugging, in addition to checkerboard alternating orthokeratosis/parakeratosis, may serve as clues to PRP diagnosis.[] The skin biopsy showed acanthosis, alternating orthokeratosis, parakeratosis, and follicular plugging suggestive of pityriasis rubra pilaris.[]

  • Psoriasis

    Histologic findings of nail psoriasis include mild-to-moderate hyperkeratosis, hypergranulosis, serum globules and hemorrhage in the corneum layer, papillomatous epidermal[] Early lesions exhibit more inflammation and less acanthosis, and very early lesions can show normal basket-weave orthokeratosis overlying parakeratotic changes.[]

  • Palmoplantar Keratosis

    A, A biopsy specimen from the dorsum of the hand shows orthokeratotic hyperkeratosis with acanthosis, hypergranulosis, and mild perivascular inflammatory infiltration.[] Histology of the representative plantar lesion in the child showed orthokeratosis and parakeratosis but absence of cornoid lamellae or elastorrhexis, confirming the diagnosis[] The second biopsy specimen from the thenar region revealed orthokeratosis without significant epidermal changes or altered acrosyringium [Figure 2] b.[]

  • Autosomal Recessive Congenital Ichthyosis ARCI5

    Light microscopy of skin biopsies revealed typical histopathologic features of ichthyosis, including hyperkeratosis or more extensive orthokeratosis, mild thickening of the[] Light microscopy of skin biopsies revealed typical histopathologic features of ichthyosis, including hyperkeratosis or more extensive orthokeratosis, mild thickening of the[] […] stratum corneum and moderate acanthosis and parakeratosis.[]

  • Epidermodysplasia Verruciformis

    […] to moderate acanthosis and hyperkeratosis Large cells with blue-gray cytoplasm, perinuclear halos, often dysplastic changes, particularly post kidney transplantation ( J[] Biopsy of a papule from chest showed irregularly acauthotic epidermis with basket weave orthokeratosis overlying papillornatous dermis.[] RESULTS Histopathology The histological findings in each patient’s biopsy included basket-weave orthokeratosis overlying a prominent granular cell layer.[]

  • Exfoliative Ichthyosis

    Lamellar Ichthyosis : The transglutaminase-1 can be stained in frozen sections of skin; histology shows orthokeratotic hyperkeratosis and mild to moderate acanthosis.[] Histologic examination revealed orthokeratosis, a thickened granular cell layer, and spongiosis without epidermolytic hyperkeratosis.[] EXFOLIATIVE, AUTOSOMAL RECESSIVE; AREI Classification skin Phenotypes Autosomal recessive inheritance ; Epidermal acanthosis ; Ichthyosis ; Lichenification ; Nail dystrophy ; Orthokeratosis[]

  • Gianotti-Crosti Syndrome

    Biopsy of the skin lesion shows hyperkeratosis with mild to moderate acanthosis, papillary dermal edema and superficial perivascular infiltrate of mononuclear cells and histiocytes[] Histopathologic analysis showed compact orthokeratosis, focal parakeratosis, hypergranulosis, psoriasiform epidermal hyperplasia, and a dense lichenoid lymphohistiocytic infiltrate[] Lymph nodes, mainly axillary and inguinal, are moderately enlarged, firm and freely movable and may persist for 2 to 3 months.[]

  • Pachyonychia Congenita

    Du et al. (2012) reported a 32-year-old Chinese woman with toenail thickening, plantar hyperkeratosis with fissuring, and mild focal palmar hyperkeratosis but no fingernail[] A biopsy can be taken from a hyperkeratotic area and observed in a light microscope where acanthosis and orthokeratosis may be seen.[] On biopsy acanthotic epidermis, parakeratosis, orthokeratosis were seen. No evidence of any associated malignancy was found after thorough workup.[]

  • Epidermal Nevus Syndrome

    Important microscopic features: Histopathology images - Hyperkeratosis, moderate acanthosis with elongation of rete ridges - There is mild spongiosis. - Characteristic histologic[] […] examination of inflammatory linear verrucous epidermal nevus reveals a similar psoriasiform hyperplasia of the epidermis, alternating parakeratosis without a granular layer, and orthokeratosis[] There is psoriasiform epidermal hyperplasia and overlying alternate parakeratosis and orthokeratotic areas of hyperkeratosis.[]

  • Lamellar Ichthyosis

    A punch biopsy specimen diagnosed the case as LI with marked hyperkeratosis, hypergranulosis and moderate acanthosis with prominent rete ridges and a mild perivascular infiltrate[] Figure 3: Section shows compact orthokeratosis, keratotic plugging and mild psoriasiform epidermal hyperplasia, consistent with lamellar ichthyosis (H and E, 100) Click here[] […] nipple 2-3 toe syndactyly Sparse body hair Oral cleft Pustule Trismus Chronic sinusitis Pili torti Conical tooth Hyperconvex nail Ankyloblepharon Selective tooth agenesis Orthokeratosis[]

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