Create issue ticket

17 Possible Causes for Mild to Moderate Hyperkeratosis, Orthokeratosis

  • Pityriasis Rubra Pilaris

    Histopathology showed mild to moderate hyperkeratosis with focal parakeratosis and hypergranulosis.[omim.org] Microscopically follicular plugging, in addition to checkerboard alternating orthokeratosis/parakeratosis, may serve as clues to PRP diagnosis.[ncbi.nlm.nih.gov] The skin biopsy showed acanthosis, alternating orthokeratosis, parakeratosis, and follicular plugging suggestive of pityriasis rubra pilaris.[ncbi.nlm.nih.gov]

  • Psoriasis

    Histologic findings of nail psoriasis include mild-to-moderate hyperkeratosis, hypergranulosis, serum globules and hemorrhage in the corneum layer, papillomatous epidermal[emedicine.com] Early lesions exhibit more inflammation and less acanthosis, and very early lesions can show normal basket-weave orthokeratosis overlying parakeratotic changes.[emedicine.com]

  • Palmoplantar Keratosis

    A, A biopsy specimen from the dorsum of the hand shows orthokeratotic hyperkeratosis with acanthosis, hypergranulosis, and mild perivascular inflammatory infiltration.[jamanetwork.com] Histology of the representative plantar lesion in the child showed orthokeratosis and parakeratosis but absence of cornoid lamellae or elastorrhexis, confirming the diagnosis[e-ijd.org] The second biopsy specimen from the thenar region revealed orthokeratosis without significant epidermal changes or altered acrosyringium [Figure 2] b.[doi.org]

  • Autosomal Recessive Congenital Ichthyosis ARCI5

    Light microscopy of skin biopsies revealed typical histopathologic features of ichthyosis, including hyperkeratosis or more extensive orthokeratosis, mild thickening of the[bio2rdf.org] Light microscopy of skin biopsies revealed typical histopathologic features of ichthyosis, including hyperkeratosis or more extensive orthokeratosis, mild thickening of the[bio2rdf.org] […] stratum corneum and moderate acanthosis and parakeratosis.[bio2rdf.org]

  • Epidermodysplasia Verruciformis

    […] to moderate acanthosis and hyperkeratosis Large cells with blue-gray cytoplasm, perinuclear halos, often dysplastic changes, particularly post kidney transplantation ( J[pathologyoutlines.com] Biopsy of a papule from chest showed irregularly acauthotic epidermis with basket weave orthokeratosis overlying papillornatous dermis.[jpma.org.pk] RESULTS Histopathology The histological findings in each patient’s biopsy included basket-weave orthokeratosis overlying a prominent granular cell layer.[academic.oup.com]

  • Exfoliative Ichthyosis

    Lamellar Ichthyosis : The transglutaminase-1 can be stained in frozen sections of skin; histology shows orthokeratotic hyperkeratosis and mild to moderate acanthosis.[slideshare.net] Histologic examination revealed orthokeratosis, a thickened granular cell layer, and spongiosis without epidermolytic hyperkeratosis.[ncbi.nlm.nih.gov] EXFOLIATIVE, AUTOSOMAL RECESSIVE; AREI Classification skin Phenotypes Autosomal recessive inheritance ; Epidermal acanthosis ; Ichthyosis ; Lichenification ; Nail dystrophy ; Orthokeratosis[mousephenotype.org]

  • Gianotti-Crosti Syndrome

    Biopsy of the skin lesion shows hyperkeratosis with mild to moderate acanthosis, papillary dermal edema and superficial perivascular infiltrate of mononuclear cells and histiocytes[ijdvl.com] Histopathologic analysis showed compact orthokeratosis, focal parakeratosis, hypergranulosis, psoriasiform epidermal hyperplasia, and a dense lichenoid lymphohistiocytic infiltrate[ncbi.nlm.nih.gov] Lymph nodes, mainly axillary and inguinal, are moderately enlarged, firm and freely movable and may persist for 2 to 3 months.[ijdvl.com]

  • Pachyonychia Congenita

    Du et al. (2012) reported a 32-year-old Chinese woman with toenail thickening, plantar hyperkeratosis with fissuring, and mild focal palmar hyperkeratosis but no fingernail[omim.org] A biopsy can be taken from a hyperkeratotic area and observed in a light microscope where acanthosis and orthokeratosis may be seen.[symptoma.com] On biopsy acanthotic epidermis, parakeratosis, orthokeratosis were seen. No evidence of any associated malignancy was found after thorough workup.[idoj.in]

  • Epidermal Nevus Syndrome

    Important microscopic features: Histopathology images - Hyperkeratosis, moderate acanthosis with elongation of rete ridges - There is mild spongiosis. - Characteristic histologic[histopathology-india.net] […] examination of inflammatory linear verrucous epidermal nevus reveals a similar psoriasiform hyperplasia of the epidermis, alternating parakeratosis without a granular layer, and orthokeratosis[dermaamin.com] There is psoriasiform epidermal hyperplasia and overlying alternate parakeratosis and orthokeratotic areas of hyperkeratosis.[histopathology-india.net]

  • Lamellar Ichthyosis

    A punch biopsy specimen diagnosed the case as LI with marked hyperkeratosis, hypergranulosis and moderate acanthosis with prominent rete ridges and a mild perivascular infiltrate[mjdrdypu.org] Figure 3: Section shows compact orthokeratosis, keratotic plugging and mild psoriasiform epidermal hyperplasia, consistent with lamellar ichthyosis (H and E, 100) Click here[ojoonline.org] […] nipple 2-3 toe syndactyly Sparse body hair Oral cleft Pustule Trismus Chronic sinusitis Pili torti Conical tooth Hyperconvex nail Ankyloblepharon Selective tooth agenesis Orthokeratosis[mendelian.co]

Further symptoms

Similar symptoms