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10 Possible Causes for Mildly Downslanting Palpebral Fissures

  • Coffin-Lowry Syndrome

    AP view of an adolescent showing relatively mild facial signs but with widely spaced eyes, mildly downslanted palpebral fissures, thick vermilion of the upper and lower lips[ncbi.nlm.nih.gov] Affected males typically have moderate-to-severe intellectual disability; since the advent of molecular genetic testing , more mildly affected males are being identified [[ncbi.nlm.nih.gov] AP view of a boy age two years with CLS showing relatively fine facial features but with widely spaced eyes, mildly downslanted palpebral fissures, short nose with broad columella[ncbi.nlm.nih.gov]

  • Acrootoocular Syndrome

    Note the mildly downslanting palpebral fissures, the bilateral asymmetrical deformity of the auricles.[pocketdentistry.com]

  • Deafness with Labyrinthine Aplasia - Microtia - Microdontia

    […] distinctive facial features such as long facies, downslanting palpebral fissures, deep-set eyes, high nasal bridge, hypoplastic alae nasi, and mild micrognathia.[ncbi.nlm.nih.gov] […] ocular abnormalities such as strabismus-hypermetropia; brain anomalies such as pontocerebellar arachnoid cysts; cardiovascular findings such as prominent azygos vein; and mildly[ncbi.nlm.nih.gov]

  • Ring Chromosome 7

    They all had an unusual face, characterized by a flat profile, short forehead, downslant of the palpebral fissures, high and broad nasal bridge, simply formed ears, and prognathia[ncbi.nlm.nih.gov] Both sibs had speech difficulties and were mildly mentally retarded whereas the mother's intelligence was at the lower end of the normal range.[ncbi.nlm.nih.gov]

  • Epicanthal Folds

    Shallow bridge to the nose, epicanthal folds (which are due to underdevelopment of the bridge of the nose), mildly downslanted palpebral fissure s, possibly a shallow philtrum[theisaacs22.wordpress.com] However, just at a cursory glance, your childhood pictures do seem to be mildly dysmorphic .[theisaacs22.wordpress.com]

  • Syndromic Orbital Border Hypoplasia

    Note the mildly downslanting palpebral fissures, the bilateral asymmetrical deformity of the auricles.[pocketdentistry.com]

  • Mandibuloacral Dysostosis

    palpebral fissures Fixed elbow flexion Distal muscle weakness Neck muscle weakness Short metacarpal Mildly elevated creatine phosphokinase Calf muscle hypertrophy Childhood[mendelian.co] Neurological speech impairment Open mouth Narrow mouth Blotching pigmentation of the skin Corneal scarring Hand clenching Alacrima Short chin Bradycardia Inguinal hernia Downslanted[mendelian.co]

  • Premature Centromere Division

    palpebral fissures, widely spaced eyes, exophthalmos resulting from shallow orbits, corneal clouding, underdeveloped ala nasi, beaked nose, and ear malformations.[flipper.diff.org] Mildly affected individuals have no palatal abnormalities or only a high-arched palate.[flipper.diff.org] Craniofacial abnormalities include: cleft lip and/or cleft palate, premaxillary prominence, micrognathia, microbrachycephaly, midfacial capillary hemangioma, malar flattening, downslanted[flipper.diff.org]

  • LEOPARD Syndrome

    palpebral fissures and pterygium colli.[karger.com] The phenotype of NS shows extreme variability, from mildly short stature with normal intelligence to severe congenital heart disease or HCM, or rarely severe learning disability[karger.com] […] defect, pectus deformities, developmental delay of variable degree, cryptorchidism which contributes to the reduced fertility, and characteristic facies including ptosis, downslanting[karger.com]

  • Moynahan Syndrome

    palpebral fissures and pterygium colli.[karger.com] The phenotype of NS shows extreme variability, from mildly short stature with normal intelligence to severe congenital heart disease or HCM, or rarely severe learning disability[karger.com] […] defect, pectus deformities, developmental delay of variable degree, cryptorchidism which contributes to the reduced fertility, and characteristic facies including ptosis, downslanting[karger.com]

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