Possible Causes for miosis Opiate Overdose Opiate overdose is characterized by respiratory depression, reduced consciousness, and miosis. [symptoma.com] Constricted pupils (miosis) or poor arousability in a slow-breathing patient further suggest opioid toxicity. [pulmccm.org] Look for the toxidrome of opiate intoxication Miosis CNS depression respiratory depression complications of hypoxia: seizures, dysrrhythmias, brain injury Whilst the obvious [stemlynsblog.org] Brain Stem Infarction Neurological examinations showed left ptosis and miosis, hoarseness, dysphagia, right mild hemiparesis, left ataxia of his extremities, and truncal ataxia. [hindawi.com] It is typified by vertigo, ipsilateral hemiataxia, dysarthria, ptosis and miosis. [tchain.com] […] structure that extends in the lateral aspect of the pons down into the medulla) Sympathetic pathway : ipsilateral Horner’s syndrome, that is partial ptosis and a small pupil (miosis [lifeinthefastlane.com] Anterior Uveitis External examination Miosis Endothelial dusting Aqueous flare and cells 20. [slideshare.net] Clinical features: Symptoms: pain due to ciliary spasm, red eye, photophobia, decreased vision and tearing Signs: Circumcorneal ciliary injection, irregular pupil or miosis [columbiaeye.org] He had circumcorneal congestion and had grade 4 cells and grade 3 flare in anterior chamber with posterior synechia and miosis. [slideshare.net] Uveitis Pupillary miosis is common. Slit-lamp examination This is the most important aspect of the examination. [emedicine.com] Spasm of the ocular sphincter muscle causes miosis. [symptoma.com] Mydriatics: Mydriatics are given to counter the severe miosis. [symptoma.com] Intrapontine Hemorrhage or autonomic instability Cerebellum - Ataxia, usually beginning in the trunk, ipsilateral facial weakness, ipsilateral sensory loss, gaze paresis, skew deviation, miosis [en.wikipedia.org] […] apo-plectiform onset with fast developing coma, and show disturbance of vegetative function (disturbance of respiration, cardiac dysrhythmias, hyperthermia, hypertension), miosis [ncbi.nlm.nih.gov] Mild ptosis with concurrent miosis OD was also found. [e-tjo.org] Heroin Dependence Decreased gastrointestinal motility (can cause constipation) Cough suppression Suppression of corticotropin-releasing factor and adrenocorticotropin hormone Pinpoint pupils (miosis [emedicine.medscape.com] Brain Stem Hemorrhage The fulminating malignant course is characterised by rapid onset of coma, miosis, tetraplegia and respiratory disturbances. [link.springer.com] Horner's Syndrome Postoperatively, left ptosis and miosis had improved slightly. [ncbi.nlm.nih.gov] Horner's syndrome is characterized by a classic triad of ipsilateral pupillary miosis, partial eyelid ptosis, and facial anhydrosis. [ncbi.nlm.nih.gov] From Wikidata Jump to navigation Jump to search Human disease characterized by miosis (a constricted pupil), partial ptosis (a weak, droopy eyelid), apparent anhydrosis (decreased [wikidata.org] Iritis […] iritis. [6], [4] IOP may be increased due to inflammatory process or it may be decreased due to damage of the ciliary body’s ability to produce aqueous humor. [10], [4] Miosis [eyewiki.aao.org] Pupillary miosis is common. Slit-lamp examination This is the most important aspect of the examination. [emedicine.medscape.com] […] what is called an iris bombé. [9] Intractable secondary glaucoma may also result following traumatic iritis. [9] Symptoms Photophobia (pain when light enters eye; pain with miosis [eyewiki.aao.org] Metabolic Encephalopathy PURPOSE: To discuss the clinical case of a patient suffering visual dysfunction secondary to a metabolic brain injury, the patient's visual rehabilitative treatment, and outcomes. CASE REPORT: A 24-year-old Caucasian male presented to the Southern Arizona Veteran's Affairs Healthcare System's Traumatic Brain Injury[…] [ncbi.nlm.nih.gov] Organophosphate Poisoning No miosis or wheeze None Discharged 10 ED Porter Portering, 30 min in room with patient Giddiness HR 60/min, BP 132/79. [academic.oup.com] Human poisoning due to amitraz may be misdiagnosed as organophosphate/carbamate (OPC) toxicity, since amitraz poisoning shares several clinical features (miosis, bradycardia [ncbi.nlm.nih.gov] After a deliberate ingestion of malathion, a 55-year-old male suffering from miosis, somnolence, bradycardia, muscular fasciculations, rales on auscultation, respiratory insufficiency [ncbi.nlm.nih.gov] Neuroblastoma Tumors in the neck or upper chest may cause Horner syndrome (ptosis, miosis, anhidrosis). [msdmanuals.com] […] often incidental Tracheal deviation with resulting stridor Superior Vena cava syndrome Cervical involvement (5%) produces the following symptoms: Horner’s syndrome (ptosis, miosis [pedclerk.bsd.uchicago.edu] […] mediastinal neuroblastoma (prenatal / postnatal interruption of sympathetic tracts that mediate pigmentation of iris) Horner's syndrome (damage to sympathetic trunk resulting in miosis [pathologyoutlines.com] Pontine Glioma A 36-year-old male was admitted with a 10-year history of gradually progressive left ear hearing loss, diplopia and right hemiparesis. Magnetic resonance imaging showed a left lateral pontine enhancing tumour and an additional cerebellopontine angle epidermoid tumour in close proximity forming a collision tumour. On[…] [ncbi.nlm.nih.gov] Central Pontine Myelinolysis Central pontine myelinolysis is a rare neurologic disorder defined by symmetric demyelination in the central base of the pons. It usually manifests with neurologic signs such as impaired consciousness, ataxia, spastic quadriparesis, pseudobulbar signs, and the locked-in syndrome which is related to a disconnection[…] [ncbi.nlm.nih.gov] Brain Stem Herniation […] insipidus Tonsillar Cerebellar tonsil below the foramen magnum Coma Apnea Hypertension Upward Flattened quadrigeminal cistern "Spinning top" midbrain Hydrocephalus Coma Miosis [derangedphysiology.com] […] severe cases Compression of the posterior midbrain (apparently, that gives it a "spinning top" appearance) Hydrocephalus Clinical features of upward brainstem herniation Coma Miosis [derangedphysiology.com] Tetraethyl Pyrophosphate Poisoning […] the muscarinic effects of organophosphates are SLUDGE ( salivation, lacrimation, urination, diarrhea, GI upset, emesis ) and DUMBELS ( diaphoresis and diarrhea; urination; miosis [slideshare.net] […] the muscarinic effects of organophosphates are SLUDGE (salivation, lacrimation, urination, diarrhea, GI upset, emesis) and DUMBELS (diaphoresis and diarrhea; urination; miosis [authorstream.com] Gastrointestinal Nausea/vomiting Increased salivation Abdominal cramps Diarrhoea Faecal incontinence Genitourinary Urinary continence Eyes Blurred vision Increased lacrimation Miosis [doctorsachin.wordpress.com] Oculocerebrorenal Syndrome Leukocoria, miosis, microphthalmos and a shallow anterior chamber has been noted in neonates. The cataractous lenses may be small and abnormally formed. [disorders.eyes.arizona.edu] Phencyclidine Intoxication Other findings less frequent but still suspect are opisthotonos, hypertension, tachypnea or hyperpnea, miosis, hyperreflexia, hypertonia, and rigidity. [journals.sagepub.com] Cluster Headache METHODS/RESULTS: Ophthalmic features such as conjunctival injection, lacrimation, ptosis and miosis occur in the vast majority of patients with cluster headache, whereas co-existent [ncbi.nlm.nih.gov] […] associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial sweating, eyelid edema, and miosis [icd9data.com] Miosis and ptosis were slightly less common in women than in men (miosis 13.3% v 24.6; ptosis 41.9% v 58.1%). [dx.doi.org] Cholinergic Crisis Other symptoms include increased sweating, salivation, bronchial secretions along with miosis (constricted pupils). [en.wikipedia.org] Other symptoms include increased sweating, salivation, bronchial secretions along with miosis. [wikidoc.org] In reply to Instructor, NCSBN : In addition, The Myasthenia Crisis caused Pupils-mydriasis but The Cholinergic crisis caused Pupils-Miosis [learningext.com] Malignant Glioma Int J Mol Sci. 2017 Feb 10;18(2). pii: E350. doi: 10.3390/ijms18020350. Author information 1 Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, China. yingying_shao1226@outlook.com. 2 Department of Clinical Pharmacology, Xiangya Hospital, Central South University,[…] [ncbi.nlm.nih.gov] Anisocoria Horner’s syndrome causes unilateral miosis, and the affected abnormal pupil either does not dilate or has a delayed dilation in the dark. [mmcneuro.wordpress.com] The most common etiology that leads to unilateral miosis include sympathetic denervation (Horner syndrome), pharmacological miosis and iridocyclitis. [dusunenadamdergisi.org] Evaluation Distinct pathways control miosis and mydriasis. The parasympathetic pathway causes miosis by activating the iris sphincter. [statpearls.com] Clonidine Poisoning All patients were lethargic on admission and most were admitted with bradycardia or miosis. Hypotension was more likely to develop after admission. [ncbi.nlm.nih.gov] Symptoms included altered level of consciousness (n 11), miosis (n 5), bradycardia (n 8), hypotension (n 5), apnea and respiratory depression (n 6), hypothermia (n 5) and [ncbi.nlm.nih.gov] The various causes of miosis are considered in Neurological Mind-boggler 002: Befuddling Pupillary Asymmetry. [lifeinthefastlane.com] Harlequin Syndrome The site of autonomic deficit was investigated in 4 patients with loss of thermoregulatory flushing and sweating on one side of the face but no associated miosis (harlequin [ncbi.nlm.nih.gov] 55-year-old woman presented to hospital with a 3-month history of asymmetric facial flushing of the skin during exertion, and an 18-month history of left-sided ptosis and miosis [ncbi.nlm.nih.gov] Horner's syndrome is characterized by miosis, ptosis, enophthalmos, and anhidrosis, and these symptoms occur on the same side as that of the nerve injury 12, 13). [doi.org] Spastic Ataxia with Congenital Miosis Spastic Ataxia 7, with Miosis Clinical Characteristics Ocular Features: Several large pedigrees have been reported in which both males and females had congenital miosis and [disorders.eyes.arizona.edu] Hereditary spastic ataxia with congenital miosis: four cases in one family. Statistics from Altmetric.com This is a PDF-only article. [bjo.bmj.com] English OMIM 108650 L6446010 preferred S13048177 Y SPASTIC ATAXIA WITH CONGENITAL MIOSIS English OMIM 108650 L6446010 preferred S7533154 Y MIOSIS, CONGENITAL, WITH SPASTIC [doctor.am] Tonic Pupil In both cases, instillation of dilute 0.1% pilocarpine caused miosis in the affected eyes. [ncbi.nlm.nih.gov] In this study, the degree of intraocular penetration of topical fluorescein was compared with the degree of pilocarpine-induced miosis in six tonic pupils and in seven age-matched [ncbi.nlm.nih.gov] Tonic pupils show progressive miosis; this miosis progresses more quickly than the normal miosis of aging. [ncbi.nlm.nih.gov] Trigeminal Autonomic Cephalalgia […] conjunctival injection) or watering ( lacrimation) of the eye, one-sided nasal congestion or discharge (rhinorrhea), forehead and facial sweating, constriction of a pupil (miosis [web.archive.org] […] more than three months duration, without pain-free intervals and associated with either conjunctival hyperaemia or tearing, nasal congestion or rhinorrhoea, or ptosis or miosis [pulsetoday.co.uk] […] clinically are consistent with cranial parasympathetic activation (lacrimation, rhinorrhoea, nasal congestion, and eyelid oedema) and sympathetic hypofunction (ptosis and miosis [doi.org] Tabes Dorsalis Tabes dorsalis is a late manifestation of untreated syphilis that is characterized by ataxia, lancinating pains, and urinary incontinence. A form of tertiary syphilis or neurosyphilis, it is the result of slow, progressive degeneration of the nerve cells in the spinal cord. Case report. A 39-year-old man presented with[…] [ncbi.nlm.nih.gov] Tubular Aggregate Myopathy We present three members of an Italian family affected by tubular aggregate myopathy (TAM) and congenital miosis harboring a novel missense mutation in ORAI1. [ncbi.nlm.nih.gov] /genetics Miosis/metabolism Muscle Fatigue/genetics Mutation, Missense* Myopathies, Structural, Congenital/genetics* Myopathies, Structural, Congenital/metabolism Neoplasm [ncbi.nlm.nih.gov] 20 January 2017 This paper described three members of an Italian family affected by tubular aggregate myopathy (TAM) and congenital miosis harboring a novel missense mutation [institut-myologie.org] Carbamate Poisoning Dyspnea and vomiting were the most common symptom and miosis and cyanosis were the most frequently observed signs. [ncbi.nlm.nih.gov] Pediatric Department of the Second University of Naples for evaluation of stupor, lethargy, severe hypotonia, generalized weakness of his arms and legs, ataxia, dysmetria, miosis [ncbi.nlm.nih.gov] In adults, the main signs were miosis and fasciculations. Fasciculations in children were less frequent. [ncbi.nlm.nih.gov]
