Miosis: Causes & Reasons

Possible Causes for Miosis

Neurological examination showed partial blepharoptosis and pupillary miosis on the right, findings compatible with right-sided Horner syndrome (figure 1). [emj.bmj.com]

Postoperatively, left ptosis and miosis had improved slightly. [ncbi.nlm.nih.gov]

Horner's syndrome is characterized by a classic triad of ipsilateral pupillary miosis, partial eyelid ptosis, and facial anhydrosis. [ncbi.nlm.nih.gov]

Intrapontine Hemorrhage

or autonomic instability Cerebellum - Ataxia, usually beginning in the trunk, ipsilateral facial weakness, ipsilateral sensory loss, gaze paresis, skew deviation, miosis [en.wikipedia.org]

[…] apo-plectiform onset with fast developing coma, and show disturbance of vegetative function (disturbance of respiration, cardiac dysrhythmias, hyperthermia, hypertension), miosis [ncbi.nlm.nih.gov]

Mild ptosis with concurrent miosis OD was also found. [e-tjo.org]

Organophosphate Poisoning

No miosis or wheeze None Discharged 10 ED Porter Portering, 30 min in room with patient Giddiness HR 60/min, BP 132/79. [academic.oup.com]

Blurry or darkened vision can be present with miosis. [emergencymedicalparamedic.com]

Atropine sulphate was administered intravenously in repeated doses to all children with bradycardia, diarrhea, salivation, and miosis. [journals.lww.com]

Opiate Overdose

Opiate overdose is characterized by respiratory depression, reduced consciousness, and miosis. [symptoma.com]

Constricted pupils (miosis) or poor arousability in a slow-breathing patient further suggest opioid toxicity. [pulmccm.org]

[…] by, last update April 2, 2019 CLINICAL FEATURES miosis CNS depression respiratory depression complications of hypoxia: seizures, dysrrhythmia, brain injury MANAGEMENT Resuscitation [lifeinthefastlane.com]

Cholinergic Crisis

Other symptoms include increased sweating, salivation, bronchial secretions along with miosis (constricted pupils). [en.wikipedia.org]

Other symptoms include increased sweating, salivation, bronchial secretions along with miosis. [wikidoc.org]

In reply to Instructor, NCSBN : In addition, The Myasthenia Crisis caused Pupils-mydriasis but The Cholinergic crisis caused Pupils-Miosis [learningext.com]

Tetraethyl Pyrophosphate Poisoning

[…] the muscarinic effects of organophosphates are SLUDGE ( salivation, lacrimation, urination, diarrhea, GI upset, emesis ) and DUMBELS ( diaphoresis and diarrhea; urination; miosis [slideshare.net]

[…] the muscarinic effects of organophosphates are SLUDGE (salivation, lacrimation, urination, diarrhea, GI upset, emesis) and DUMBELS (diaphoresis and diarrhea; urination; miosis [authorstream.com]

Gastrointestinal Nausea/vomiting Increased salivation Abdominal cramps Diarrhoea Faecal incontinence Genitourinary Urinary continence Eyes Blurred vision Increased lacrimation Miosis [doctorsachin.wordpress.com]

Anterior Uveitis

External examination Miosis Endothelial dusting Aqueous flare and cells 20. [slideshare.net]

Clinical features: Symptoms: pain due to ciliary spasm, red eye, photophobia, decreased vision and tearing Signs: Circumcorneal ciliary injection, irregular pupil or miosis [dro.hs.columbia.edu]

He had circumcorneal congestion and had grade +4 cells and grade +3 flare in anterior chamber with posterior synechia and miosis. [slideshare.net]

Brain Stem Infarction

It is typified by vertigo, ipsilateral hemiataxia, dysarthria, ptosis and miosis. [tchain.com]

[…] structure that extends in the lateral aspect of the pons down into the medulla) Sympathetic pathway : ipsilateral Horner’s syndrome, that is partial ptosis and a small pupil (miosis [lifeinthefastlane.com]

Neurological examinations showed left ptosis and miosis, hoarseness, dysphagia, right mild hemiparesis, left ataxia of his extremities, and truncal ataxia. [hindawi.com]

Uveitis

Spasm of the ocular sphincter muscle causes miosis. [symptoma.com]

Pupillary miosis is common. Slit-lamp examination This is the most important aspect of the examination. [emedicine.com]

Mydriatics: Mydriatics are given to counter the severe miosis. [symptoma.com]

Brain Stem Hemorrhage

The fulminating malignant course is characterised by rapid onset of coma, miosis, tetraplegia and respiratory disturbances. [link.springer.com]

Phencyclidine Intoxication

QID: 205717 Miosis, drowsiness, constipation Disorientation, hallucinations, hostility Amnesia, ataxia, stupor, somnolence Hyperphagia, hypersomnolence, fatigue Restlessness [step1.medbullets.com]

Other findings less frequent but still suspect are opisthotonos, hypertension, tachypnea or hyperpnea, miosis, hyperreflexia, hypertonia, and rigidity. [journals.sagepub.com]

Iritis

[…] to the inflammatory process, damage to the trabecular meshwork, and/or it may be decreased due to damage of the ciliary body’s ability to produce aqueous humor.[10],[4] Miosis [eyewiki.aao.org]

[…] iritis. [6], [4] IOP may be increased due to inflammatory process or it may be decreased due to damage of the ciliary body’s ability to produce aqueous humor. [10], [4] Miosis [eyewiki.aao.org]

Pupillary miosis is common. Slit-lamp examination This is the most important aspect of the examination. [emedicine.medscape.com]

Carbachol

Intraocular injection: Maximal miosis occurs within 2–5 minutes. [drugs.com]

INDICATIONS Intraocular use for obtaining miosis during surgery. [rxlist.com]

Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. [ebi.ac.uk]

Exposure to Nerve Gas

Symptoms may include miosis, red conjunctiva, dimmed or blurry vision, pain, nausea and vomiting, rhinorrhea, increased salivation, tightness in chest, cough, and dyspnea. [centerforhealthsecurity.org]

Miosis is a very characteristic symptom of nerve agent intoxication. Victims will often report difficulty in seeing (blurred & dimmed vision). [besurvival.com]

These include, intense constriction of the pupils (miosis) and severe eye pain, constriction of the bronchioles producing labored breathing, nausea and vomiting, lacrimation [sites.duke.edu]

Brain Stem Herniation

[…] insipidus Tonsillar Cerebellar tonsil below the foramen magnum Coma Apnea Hypertension Upward Flattened quadrigeminal cistern "Spinning top" midbrain Hydrocephalus Coma Miosis [derangedphysiology.com]

[…] severe cases Compression of the posterior midbrain (apparently, that gives it a "spinning top" appearance) Hydrocephalus Clinical features of upward brainstem herniation Coma Miosis [derangedphysiology.com]

Aromatic L-Amino Acid Decarboxylase Deficiency

Resulting signs and symptoms can include droopy eyelids (ptosis), constriction of the pupils of the eyes (miosis), inappropriate or impaired sweating, nasal congestion, drooling [ghr.nlm.nih.gov]

Autonomic symptoms may include droopy eye lids (ptosis ), constriction of the pupils of the eyes (miosis), inappropriate or impaired sweating, nasal congestion, drooling, [rarediseases.info.nih.gov]

Autonomic symptoms have included ptosis, miosis, paroxysmal sweating, nasal congestion, temperature instability, hypotension, and gastroesophageal reflux. [jn.nutrition.org]

Organophosphate Insecticide Antagonists

The pupillary response (resolution of miosis) is not considered an end point of atropine therapy, as miosis may persist for weeks after significant exposure [ 11 ]. [intjem.springeropen.com]

Miosis 2. Muscle Twitching and Fasciculations These two are not seen with Flit (2% chlordane with kerosene). [jpma.org.pk]

Miosis is commonly observed, as are symptoms of central nervous system (CNS) toxicity, such as anxiety and restlessness. [clinicaladvisor.com]

Neuroblastoma

Tumors in the neck or upper chest may cause Horner syndrome (ptosis, miosis, anhidrosis). [msdmanuals.com]

[…] often incidental Tracheal deviation with resulting stridor Superior Vena cava syndrome Cervical involvement (5%) produces the following symptoms: Horner’s syndrome (ptosis, miosis [pedclerk.bsd.uchicago.edu]

Heroin Dependence

Decreased gastrointestinal motility (can cause constipation) Cough suppression Suppression of corticotropin-releasing factor and adrenocorticotropin hormone Pinpoint pupils (miosis [emedicine.medscape.com]

Opioid intoxication [ edit ] Signs and symptoms of opioid intoxication include: [5] [22] Decreased perception of pain Euphoria Confusion Desire to sleep Nausea Constipation Miosis [en.wikipedia.org]

Oculocerebrorenal Syndrome

Leukocoria, miosis, microphthalmos and a shallow anterior chamber has been noted in neonates. The cataractous lenses may be small and abnormally formed. [disorders.eyes.arizona.edu]

Tabes Dorsalis

[…] che interessa i cordoni posteriori del midollo spinale, con disturbi della sensibilità, atassia, assenza di riflessi, crisi dolorose, disturbi sfinterici, atrofia ottica e miosi [abebooks.com]

Pilocarpus

It may also lead to ocular miosis. What Are The Side Effects /Adverse Reactions of Jaborandi? [amazondiscovery.com]

Substance Abuse

Abstract Hospital-wide rumors and anecdotal reports had suggested that there was a potentially serious problem of alcohol and drug abuse among the psychiatric patients of this hospital. The authors describe a systematic, evaluative approach which gave direct and detailed information on the nature and extent of[…] [ncbi.nlm.nih.gov]

Iatrogenic Opiate Addiction

A respiratory rate of 12 or less, with or without miosis and evidence of opioid abuse, is highly sensitive in predicting opioid overdose in the pre-hospital setting. [clinicaladvisor.com]

Fentanyl

Fentanyl, fentanyl analogs and other novel synthetic opioids are all full agonists of varying potencies at the μ-opioid receptor, leading to typical clinical effects of miosis [ncbi.nlm.nih.gov]

[…] and pediatric patients with an overall frequency of < 1% and are listed in descending frequency within each System/Organ Class: Cardiac disorders: cyanosis Eye disorders: miosis [rxlist.com]

Kappa 1: Spinal analgesia and miosis. Kappa 2: Dysphoria and psychotomimesis. Kappa 3: Supraspinal analgesia. [acilbook.com]

Metabolic Encephalopathy

Metabolic encephalopathy is a transient or permanent impairment of brain function resulting from physiological insufficiency or aberrant metabolic processes accompanying certain systemic illness such as diabetes or liver disease. Timely recognition and treatment of the predisposing condition can reverse the potential[…] [symptoma.com]

Pontine Glioma

Diffuse intrinsic pontine gliomas (DIPG) are pediatric high-grade gliomas (pHGG) that are infiltrative tumors of the brainstem. Illustration of a brain tumor. Image Credit: royaltystockphoto.com / Shutterstock.com What is DIPG? Like other tumors that arise in midline structures of the brain, most DIPGs are histone[…] [news-medical.net]

Central Pontine Myelinolysis

Central pontine myelinolysis is a rare neurologic disorder defined by symmetric demyelination in the central base of the pons. It usually manifests with neurologic signs such as impaired consciousness, ataxia, spastic quadriparesis, pseudobulbar signs, and the locked-in syndrome which is related to a disconnection[…] [ncbi.nlm.nih.gov]

Cluster Headache

The examination would reveal ptosis and miosis and other associated sign. [symptoma.com]

METHODS/RESULTS: Ophthalmic features such as conjunctival injection, lacrimation, ptosis and miosis occur in the vast majority of patients with cluster headache, whereas co-existent [ncbi.nlm.nih.gov]

[…] conjunctival injection and/or lacrimation ipsilateral nasal congestion and/or rhinorrhoea ipsilateral eyelid oedema ipsilateral forehead and facial sweating ipsilateral miosis [healthcentral.com]

Malignant Glioma

MRI of a diffuse midline glioma in the brain. Credit: NCI-CONNECT Staff Diffuse midline gliomas are primary central nervous system (CNS) tumors. This means they begin in the brain or spinal cord. Diffuse midline glioma is a rare subtype of glial tumors. To get an accurate diagnosis, a piece of tumor tissue will be[…] [cancer.gov]