Create issue ticket

26 Possible Causes for Mitochondria with Abnormal Cristae Increased

  • Liver Fibrosis

    Electron microscopic investigation showed an increased number of mitochondria with rare or enlarged cristae.[ncbi.nlm.nih.gov] Light microscopy performed on liver biopsies revealed steatosis, abnormal hepatocytes with an "oncocytic" appearance and extensive fibrosis.[ncbi.nlm.nih.gov]

  • Chronic Progressive External Ophthalmoplegia

    mitochondria (Figure 1). 3 Electron microscopy reveals increased numbers of abnormal mitochondria.[eyewiki.aao.org] The mitochondria are often enlarged, with disorganized cristae and paracrystalline inclusions.[eyewiki.aao.org] General Pathology Skeletal muscle biopsy stained with Massons or Gomori trichrome exhibits “ragged red fibers” resulting from increased numbers of enlarged sub-sarcolemmal[eyewiki.aao.org]

  • Danon Disease

    Mitochondria appeared to be of normal density with no demonstrable abnormal cristae pattern or intramitochondrial inclusions.[circ.ahajournals.org] There was an increase in glycogen granules with subsarcolemmal accumulation.[circ.ahajournals.org]

  • Barth Syndrome

    CL ratios result in abnormal cristae formation and inefficient ETC-mediated ATP production.[doi.org] , which serves as a crucial binding site for electron transport chain (ETC) proteins and stabilization of the ETC supercomplexes. 6–9 In BTHS mitochondria, the increased MLCL[doi.org] MLCL/CL ratios. 1–5 The unique composition of mature CL is responsible for maintenance of mitochondrial membrane fluidity, osmotic stability, and proper curvature of the cristae[doi.org]

  • Myopathic Carnitine Deficiency

    […] in RRF negative patients: Increased collections of subsarcolemma mitochondria Abnormal mitochondrial structure; increased, distorted and abnormally arranged cristae Abnormal[neurodiffdx.com] mitochondria: Over abundant tightly packed disorganized cristae of the mitochondrion Small electron dense osmiophilic bodies in the mitochondrion Occasional para crystalline[neurodiffdx.com] mitochondria may be seen in: Normal muscle Denervated muscle Acid maltase deficiency Polymyositis Brain neuropathology in mitochondrial disorders: Spongiform degeneration[neurodiffdx.com]

  • Scapuloperoneal Spinal Muscular Atrophy

    The electron microscopy examination disclosed increased numbers of abnormal mitochondria disrupting the usual cell structure; the mitochondria were of various sizes with irregular[ncbi.nlm.nih.gov] […] and abnormal structure of the cristae.[ncbi.nlm.nih.gov]

  • Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

    […] in RRF negative patients: Increased collections of subsarcolemma mitochondria Abnormal mitochondrial structure; increased, distorted and abnormally arranged cristae Abnormal[neurodiffdx.com] mitochondria: Over abundant tightly packed disorganized cristae of the mitochondrion Small electron dense osmiophilic bodies in the mitochondrion Occasional para crystalline[neurodiffdx.com] mitochondria may be seen in: Normal muscle Denervated muscle Acid maltase deficiency Polymyositis Brain neuropathology in mitochondrial disorders: Spongiform degeneration[neurodiffdx.com]

  • Episodic Mitochondrial Myopathy - Optic Atrophy - Reversible Leukoencephalopathy

    Electron microscopy may show abnormal mitochondria with increased size and abnormal cristae (see histopathological findings in Figures 5 and 6 of “Primer on mitochondrial[bcmj.org] For example, the presence of multiple ragged-red fibres with modified Gomori trichrome stain indicates abnormalities of mitochondrial function with compensatory mitochondrial[bcmj.org]

  • Mitochondrial DNA Deletion Syndrome with Progressive Myopathy

    mitochondria (Figure 1). 3 Electron microscopy reveals increased numbers of abnormal mitochondria.[eyewiki.aao.org] The mitochondria are often enlarged, with disorganized cristae and paracrystalline inclusions.[eyewiki.aao.org] General Pathology Skeletal muscle biopsy stained with Massons or Gomori trichrome exhibits “ragged red fibers” resulting from increased numbers of enlarged sub-sarcolemmal[eyewiki.aao.org]

  • Mitochondrial DNA Depletion Syndrome

    In some cases, structurally altered mitochondria with abnormal cristae on electron microscopy In the majority of individuals, abnormal electron transport chain activity The[ncbi.nlm.nih.gov] Elevated in most affected individuals Muscle biopsy findings Increased fiber size variability, atrophic fibers, intracellular lipid accumulation, and COX-deficient fibers[ncbi.nlm.nih.gov]

Further symptoms