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7 Possible Causes for Mitochondrial NADPH Decreased

  • Chronic Fatigue Syndrome

    When mitochondrial electron transport decreases for any reason, fewer molecules of oxygen are converted to water (H 2 O) by cytochrome c oxidase.[dx.doi.org] […] equivalents as NADPH.[dx.doi.org] Therefore, NADPH acts as a global barometer of cellular fuel status by interrogating both mitochondrial electron (NADH) consumption and the availability of cytoplasmic reducing[dx.doi.org]

  • Pulmonary Hypertension

    A decrease of ROS has been attributed to a decreased mitochondrial ROS release (from complex I and III).[doi.org] […] interferes with mitochondrial complex I/III or inhibits complex IV, above the range of changing the cellular energy status, to increase ROS; or 2) that an activation of NADPH[doi.org]

  • Alcoholic Cardiomyopathy

    Murine cardiomyocytes (CMs) exposed to ACA or EtOH showed increased superoxide (O2(•-)) levels and decreased mitochondrial polarization, both being normalized by NADPH oxidase[ncbi.nlm.nih.gov]

  • Silicotuberculosis

    ROS production in addition to NADPH oxidase.[doi.org] ASC- and Nalp3-Deficient Mice Have Decreased Pulmonary Pathology in Response to Inhaled Silica.[doi.org] […] silica-induced IL-1β secretion, they do not distinguish between the two most likely sources for ROS in stimulated cells, because DPI can also exert inhibitory effects on mitochondrial[doi.org]

  • Silicosis

    ROS production in addition to NADPH oxidase.[doi.org] ASC- and Nalp3-Deficient Mice Have Decreased Pulmonary Pathology in Response to Inhaled Silica.[doi.org] […] silica-induced IL-1β secretion, they do not distinguish between the two most likely sources for ROS in stimulated cells, because DPI can also exert inhibitory effects on mitochondrial[doi.org]

  • Emetine

    The serial cascade of the alteration of glucose metabolism including the decreased mitochondrial membrane potential, the alteration of pentose phosphate pathway, and the reduction[bloodjournal.org] […] of NADPH and glutathione leading to the accrual of reactive oxygen species (ROS) was observed under the presence of emetine.[bloodjournal.org]

  • Aging

    […] liver NADPH oxidase activity, increased muscle mitochondrial biogenesis and decreased gastrocnemius age-dependent autophagy in aged rats, Free Radical Research, 46, 9, (1140[doi.org] , Beatrice Chabi, Gilles Fouret, Guillaume Py, Badie Sairafi, Cecile Elong, Sylvie Gaillet, Jean Paul Cristol, Charles Coudray and Christine Feillet-Coudray, Polyphenols decreased[doi.org]

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