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294 Possible Causes for Monocytosis, Splenomegaly

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[] For excessive monocyte counts more generally, see monocytosis .[] In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical[]

  • Malignant Neoplasm

    Angiomatous meningioma is a rare and distinct meningioma variant characterised with predominance of microvascularcomponent.There are few reported cases in literature with limited information on ophthalmic manifestations and radiological findings. There is no consistent feature reported so far of this neoplasm to aid[…][]

  • Polycythemia Vera

    […] in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[] […] patients with monocytosis is akin to those of patients with CMML and might partly contribute to their worse prognosis.[] […] efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly[]

  • Chronic Myelomonocytic Leukemia

    Splenomegaly is frequently seen and may be massive.[] The diagnosis of CMML requires absolute monocytosis ( 1000/μL) in addition to other criteria outlined by the World Health Organization (WHO) classification.(1) Monocytosis[] These patients are vulnerable to hepatic toxicity and graft failure after HSCT because of their increased likelihood of portal hypertension, massive splenomegaly, and extensive[]

  • Disseminated Tuberculosis

    Splenic tuberculosis leads to splenomegaly, nausea, vomiting and abdominal pain.[] The patient’s cytopenias and monocytosis were an initial clue that was consistent with disseminated TB.[] Splenomegaly showed multiple hypermetabolic nodules, and hypermetabolic focal lesions in the C3, C4, and D8 vertebral bodies, and the fourth costal arch.[]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[] […] neoplastic hematopoietic disorders, such as lymphoma, myelodysplastic syndromes, multiple myeloma, aplastic anemia, severe megaloblastic anemia, severe lymphocytosis, severe monocytosis[] Symptoms include splenomegaly, monocytosis with granulocytosis, and thrombocytopenia. leukemia cu tis leukemia with leukocytic invasion of the skin marked by pink, reddish[]

  • Leukemia

    CT, MRI, or abdominal ultrasonography may help assess splenomegaly or leukemic infiltration of other organs.[] No other obvious cause for Leukocytosis (e.g. infection, Corticosteroid s) Step 1: Consider secondary causes based on white cell count differential Monocyte predominance (monocytosis[] […] fatigue Pain in bone Fever accompanied by chills Excessive sweating especially during night hours Easy prone to infections Bleeding or bruising very easily Hepatomegaly Splenomegaly[]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[] No monocytosis, eosinophilia, or basophilia is present, nor is there a philadelphia chromosome or bcr-abl fusion gene (genes, abl).[] May see monocytosis and UP TO 5% BLASTs in PB (Merck p. 954). [Consider this in any patient with refractory anemia, especially if it is macrocytic.][]

  • Immune Thrombocytopenic Purpura

    Clinical examination revealed mucosal hemorrhages and splenomegaly.[] Various hematologic abnormalities such as anemia, leukocytosis, monocytosis, lymphopenia, leucopenia, thrombocytopenia, thrombocytosis, leukemoid reactions and pancytopenia[] There is no evidence of splenomegaly on abdominal exam.[]

  • Hodgkin's Disease

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[] Opazili včasih monocytosis je malo verjetno, da ima diagnostično vrednost. V kasnejših fazah, pogosto ugotovijo, hipokromna anemija.[] Hodgkin's lymphoma symptoms include night sweats, enlarged lymph nodes, splenomegaly, and back pain. Treatment entails radiotherapy or chemotherapy.[]

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