More Common in Ashkenazi Jews: Causes & Reasons

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Possible Causes for More Common in Ashkenazi Jews

Niemann-Pick Disease Type B

NPD-B is pan-ethnic, unlike NPD-A which is much more common in Ashkenazi Jews. [radiopaedia.org]

Onset in infancy or childhood Variable phenotype More common in Ashkenazi Jews Allelic disorder to Niemann-Pick disease type A (MIM.257200) short stature (less common) cherry-red [humpath.com]

common in Ashkenazi Jews and is characterized by accumulation of excess sphingomyelin and cholesterol in the brain, BM, liver, spleen Clinical Early infancy onset with feeding [medical-dictionary.thefreedictionary.com]

Niemann-Pick Disease Type A

Bloom Syndrome

More common in Ashkenazi Jews from Eastern Europe. Autosomal recessive. Gene map locus 15q26.1. [accessanesthesiology.mhmedical.com]

This could explain why BS is more common in Ashkenazi Jews. The founder effect hypothesis can explain the increased frequency of the blm gene in Ashkenazi Jews. [www-personal.umd.umich.edu]

The syndrome is relatively more common among Ashkenazi Jews. [hematology.blueprintgenetics.com]

Glycogen Storage Disease Type 6

The disease is more common among Ashkenazi Jews. It is treated with a special diet, but serious complications may still occur. [snpedia.com]

Niemann-Pick Disease Type D

[…] the liver Niemann-Pick disease Metabolism A rapidly progressive AR storage disease with progressive neurologic damage due to sphingomyelinase deficiency; NPD type A is AR, more [medical-dictionary.thefreedictionary.com]

Perinatal Lethal Gaucher Disease

Gaucher disease affects approximately 10,000 to 20,000 Americans and is more common among Ashkenazi Jews. [grantome.com]

Some are more common in patients with specific ethnicities; for instance, N370S (c.1226A > G) in Ashkenazi Jews. 5 Hruska KS, LaMarca ME, Scott CR, Sidransky E. [tandfonline.com]

Maple Syrup Urine Disease Mild Variant

The disease is also more common among Ashkenazi Jews, with roughly 1 in 50,000 affected by MSUD type 1B. How is Maple Syrup Urine Disease Type 1B treated? [counsyl.com]

Upper Gingival Carcinoma

common in African Americans Gender – more common in men Religious background – more common in Ashkenazi Jews Chronic pancreatitis Diabetes Obesity Diet – diets high in meats [foxnews.com]

[…] factors which may increase the risk of pancreatic cancer include: Cigarette smoking Age – over 80 percent of pancreatic cancers develop between the ages of 60 and 80 Race – more [foxnews.com]

Hereditary Sensory and Autonomic Neuropathy Type 1C

Wikipedia This disease is more common in Ashkenazi Jews, with an incidence of about 1 in 3,600 births. It is caused by mutations in the IKBKAP gene. [snpedia.com]

Classic Maple Syrup Urine Disease

The disease is also more common among Ashkenazi Jews, with roughly 1 in 50,000 affected by MSUD type 1B. How is Maple Syrup Urine Disease Type 1B treated? [counsyl.com]

Intermittent Maple Syrup Urine Disease

The disease is also more common among Ashkenazi Jews, with roughly 1 in 50,000 affected by MSUD type 1B. How is Maple Syrup Urine Disease Type 1B treated? [counsyl.com]

Hereditary Factor XI Deficiency

It is more common among Ashkenazi Jews (nearly 1 in every 8), but it affects non-Jewish people as well. Factor XI deficiency occurs in 1 in every million people. [rarebleedingdisorders.com]

Abstract Severe factor XI (FXI) deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. [ncbi.nlm.nih.gov]

In the past two decades, more than 180 mutations in the FXI gene have been reported in patients with FXI deficiency, five of which show a founder effect (Cys38Arg, Gln88Stop [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 7

It is more common in Ashkenazi Jews. [ 1 ] Presentation Infantile-onset form [ 2 ] The cases reported have presented under the age of 1 year. [patient.info]

Males appear to be affected more commonly than females. [patient.info]

Dysmyelination with Jaundice

common in Ashkenazi jews AKA visceral form, also d/t sphingomyelinase def usually d/t mutation in NPC1 gene on 18q (which encodes the Niemann-Pick C1 protein), can also be [quizlet.com]

common in Ashkenazi jews first few months of life with irritability, sensitivity to noise, increased startle; then progressive weakness, hypotonia and hyperreflexia may develop [quizlet.com]

[…] cholesterol and LDL, very low HDL lysosomal storage disorder affecting grey matter GM2 gangliosidosis due to mutation in alpha subunit of hexosaminidase A gene AR, chr 15 More [quizlet.com]

Tay-Sachs Disease

The genetic disorder is more common in Ashkenazi Jews, a group of people whose heritage is from central and eastern Europe. [healthdirect.gov.au]

Some of the studies appeared to suggest that the disease was more common among Ashkenazi Jews, which has since been shown to be false, leading to the stigmatization of these [news-medical.net]

common in Ashkenazi (European) Jews (carrier frequency, 1 in 27) than in general populations (carrier frequency, 1 in 250). 4 Affected babies appear normal at birth, then [mja.com.au]

Primary Torsion Dystonia

Childhood- and adolescent-onset primary dystonia is more common in Jews of Eastern European or Ashkenazi ancestry than in other groups. [symptoma.com]

Several large studies have shown that early-onset primary torsion dystonia is 5-10 times more common in Ashkenazi Jews than in people who were not Jewish or in Jewish individuals [symptoma.com]

Late-onset focal primary dystonia was 10 times more common than early-onset generalized primary torsion dystonia. [symptoma.com]

Lethal Ataxia with Deafness and Optic Atrophy

common in Ashkenazi jews AKA visceral form, also d/t sphingomyelinase def usually d/t mutation in NPC1 gene on 18q (which encodes the Niemann-Pick C1 protein), can also be [quizlet.com]

common in Ashkenazi jews first few months of life with irritability, sensitivity to noise, increased startle; then progressive weakness, hypotonia and hyperreflexia may develop [quizlet.com]

[…] cholesterol and LDL, very low HDL lysosomal storage disorder affecting grey matter GM2 gangliosidosis due to mutation in alpha subunit of hexosaminidase A gene AR, chr 15 More [quizlet.com]

Myelocerebellar Disorder

The incidence of FA is approximately 1 to 5 per million. 2 This condition is more common among the people of Ashkenazi Jews, with carrier frequency of 1 in 89 3, and black [bmrcbd.org]

Maple Syrup Urine Disease

The disease is also more common among Ashkenazi Jews, with roughly 1 in 50,000 affected by MSUD type 1B. How is Maple Syrup Urine Disease Type 1B treated? [jscreen.org]

MSUD type 1B is more than twice as common in Ashkenazi Jews as in the general population. Type 1A is more common in Old Order Mennonites. [snpedia.com]

Niemann-Pick Disease

Niemann-Pick disease [ Wikipedia ], a lysosomal storage disease, is more common among some ethnic groups, including Ashkenazi Jews, North Africans, Arabs, and Turks. [snpedia.com]

Platelet-Type Bleeding Disorder 15

common in Ashkenazi Jews, with a prevalence of 1:190 homozygous (carrying two defect genes). [mywbdn.org]

FXI) deficiency The incidence of FXI deficiency (sometimes called hemophilia C) is estimated at 1 in 1 million in the background population; however, the disease is much more [mywbdn.org]

Adult-Onset Cervical Dystonia Type DYT23

common in Jews of Eastern European or Ashkenazi ancestry than in other groups and seemingly rare in Far Eastern populations. [misc.medscape.com]

Ashkenazi Jews than in people who were not Jewish or in Jewish individuals not of Ashkenazi heritage. [misc.medscape.com]

common than early-onset generalized primary torsion dystonia. [11] Several large studies have shown that early-onset primary torsion dystonia is 5-10 times more common in [misc.medscape.com]

Autosomal Recessive Myeloproliferative Disease

common in Ashkenazi Jews -*** Lack of Beta-glucocerebrosidase - Unable to digest the stroma of ingested cells - Lipid accumulates in macrophages (Gaucher cells) - Large cells [brainscape.com]

[…] rare (ex. tetrachloroethane) - Gaucher’s Disease - Niemann-Pick Disease - Tay-Sachs Disease - lipid storage disease - Autosomal recessive, lipid storage disease - Type I more [brainscape.com]

Familial Dysautonomia

Wikipedia This disease is more common in Ashkenazi Jews, with an incidence of about 1 in 3,600 births. It is caused by mutations in the IKBKAP gene. [snpedia.com]

FD is rare worldwide but is more common among Ashkenazi Jews (AJ). [rarediseasesjournal.com]

Canavan Disease

The carrier frequency for the two common mutations among Ashkenazi Jews was found to be surprisingly high, 1:37. [ncbi.nlm.nih.gov]

The disease however, is more common in people of Ashkenazi Jew ancestry although people from other ethnic background can also get affected. [healthool.com]

It is more frequent among Ashkenazi Jews from eastern Poland, Lithuania, and western Russia, and among Saudi Arabians. [leukodystrophyresourceresearch.org]

Gaucher Disease

It is more common among Ashkenazi Jews, affecting 1 in 850. Signs and symptoms may appear at any age. [cerezyme.com]

Gaucher disease is more common among Jews of Ashkenazi (Eastern European) descent, occurring in approximately 1 in 450 within this population. [gaucherdisease.org]

The defective genes are more common among Ashkenazi Jews, occurring in 1 out of every 850 births within this population. [gaucherdisease.org.uk]

Glycogen Storage Disease

The disease is more common among Ashkenazi Jews. It is treated with a special diet, but serious complications may still occur. [snpedia.com]

Fanconi Anemia

The condition affects around 1 in 350,000 births and is more common among Ashkenazi Jews and Afrikaners. [news-medical.net]

This condition is more common among the people of Ashkenazi Jews, with carrier frequency of 1 in 89 [17], and black South Africans where the carrier frequency is 1 in 83 [ [ijponline.biomedcentral.com]

Crohn Disease

It occurs about equally in both sexes, often runs in families, and seems to be more common among Ashkenazi Jews. [msdmanuals.com]

More common in white populations and people of Jewish descent (especially Ashkenazi Jews, middle European Jews) References: [1] [2] [3] Epidemiological data refers to the [amboss.com]

However, it is most common among people of Northern European and Anglo-Saxon descent. [msdmanuals.com]

Inflammatory Bowel Disease

IBD is most common among people of Northern European and Anglo-Saxon origin and is 2 to 4 times more common among Ashkenazi Jews than non-Jewish whites from the same geographic [merckmanuals.com]

[…] descended from Ashkenazi Jews.12 It is seen more commonly among people who have lived for generations in Eastern Europe and Russia. [pfizer.com]

UC is more likely to develop between the ages of 15 and 30 years but can also develop in older individuals.11 UC is most common in those of European descent, especially those [pfizer.com]