More-common-in-ashkenazi-jews: Causes & Reasons

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Possible Causes for more common in ashkenazi jews

Niemann-Pick Disease Type B

NPD-B is pan-ethnic, unlike NPD-A which is much more common in Ashkenazi Jews. [radiopaedia.org]

Onset in infancy or childhood Variable phenotype More common in Ashkenazi Jews Allelic disorder to Niemann-Pick disease type A (MIM.257200) short stature (less common) cherry-red [humpath.com]

common in Ashkenazi Jews and is characterized by accumulation of excess sphingomyelin and cholesterol in the brain, BM, liver, spleen Clinical Early infancy onset with feeding [medical-dictionary.thefreedictionary.com]

Bloom Syndrome

More common in Ashkenazi Jews from Eastern Europe. Autosomal recessive. Gene map locus 15q26.1. [accessanesthesiology.mhmedical.com]

This could explain why BS is more common in Ashkenazi Jews. The founder effect hypothesis can explain the increased frequency of the blm gene in Ashkenazi Jews. [www-personal.umd.umich.edu]

The syndrome is relatively more common among Ashkenazi Jews. [hematology.blueprintgenetics.com]

Geographic Tongue

[…] of the rare disorders and has a more variable bleeding tendency than hemophilia A or B. [64], [65] The deficiency is particularly common in Ashkenazi Jews, where the carrier [doi.org]

[…] between blood relatives is common and, in rare cases, individuals may inherit more than one disorder. [63] Factor XI deficiency, also known as hemophilia C, is the most common [doi.org]

Malignant Neoplasm of the Breast

The mutations are more common among Ashkenazi Jews. [merckmanuals.com]

Hypercholesterolemia

FH is more common in certain populations (e.g. 1/270 in French Canadians, 1/100 in Lebanese and Afrikaners, and 1/67 in Ashkenazi Jews in South Africa) due to founder effects [geneticseducation.ca]

Colitis

UC can develop in a person of any race, but it’s more common in Caucasians. [healthline.com]

Jews of Eastern European (Ashkenazi) descent are at especially high risk. [mountsinai.org]

If you’re an Ashkenazi Jew, you have a greater chance of developing the condition than most other groups. [healthline.com]

Coagulation Abnormalities

[…] ethnic groups, with an incidence of about one in 10,000 among Ashkenazi Jews. [healthofchildren.com]

Factor XI deficiency, or hemophilia C, afflicts one in 100,000 people and is the second most common bleeding disorder among women; it occurs more frequently among certain [healthofchildren.com]

Canavan Disease

Abstract Canavan disease is a severe leukodystrophy more common among Ashkenazi Jews. The enzyme defect, apartoacylase, has been identified, and the gene cloned. [ncbi.nlm.nih.gov]

The carrier frequency for the two common mutations among Ashkenazi Jews was found to be surprisingly high, 1:37. [ncbi.nlm.nih.gov]

The disease however, is more common in people of Ashkenazi Jew ancestry although people from other ethnic background can also get affected. [healthool.com]

Lynch Syndrome Type 1

In this study we report of a common mutation in the MSH6 gene in Ashkenazi Jews. [ncbi.nlm.nih.gov]

This mutation is rarely found in the general population but is more common in young Ashkenazi Jews with colorectal cancer. [emedicine.medscape.com]

Lynch syndrome resulting from mutations in MSH6 is considered to be attenuated in comparison to that caused by mutations in MLH1 and MSH2, thus more likely to be under diagnosed [ncbi.nlm.nih.gov]

Heterozygous Familial Hypercholesterolemia

FH is more prevalent in certain populations, including French Canadians, Ashkenazi Jews, and South African Afrikaners. [thefhfoundation.org]

It is one of the most common genetic disorders. Homozygous FH is very rare, affecting about 1 in 1 million people worldwide. [thefhfoundation.org]

Adenocarcinoma of the Breast

The mutations are more common among Ashkenazi Jews. [merckmanuals.com]

Carcinoma of the Breast

The mutations are more common among Ashkenazi Jews. [merckmanuals.com]

Inflammatory Bowel Disease

IBD is most common among people of Northern European and Anglo-Saxon origin and is 2 to 4 times more common among Ashkenazi Jews than non-Jewish whites from the same geographic [msdmanuals.com]

[…] descended from Ashkenazi Jews.12 It is seen more commonly among people who have lived for generations in Eastern Europe and Russia. [pfizer.com]

UC is more likely to develop between the ages of 15 and 30 years but can also develop in older individuals.11 UC is most common in those of European descent, especially those [pfizer.com]

Glycogen Storage Disease Type 6

The disease is more common among Ashkenazi Jews. It is treated with a special diet, but serious complications may still occur. [snpedia.com]

Malignant Neoplasm of the Prostate

More common in some ethnic groups than other. Especially common in Ashkenazi Jews (2% of population). [slideplayer.com]

Perinatal Lethal Gaucher Disease

Gaucher disease affects approximately 10,000 to 20,000 Americans and is more common among Ashkenazi Jews. [grantome.com]

Some are more common in patients with specific ethnicities; for instance, N370S (c.1226A G) in Ashkenazi Jews. 5 Hruska KS, LaMarca ME, Scott CR, Sidransky E. [tandfonline.com]

Young-Onset Parkinson Disease

It's more common among some ethnicities, such as Ashkenazi Jews and North African Berbers. [edition.cnn.com]

Neoplasm of the Pancreas

Religious background: Pancreatic cancer is proportionally more common in Ashkenazi Jews than the rest of the population. [pathology.jhu.edu]

Gender: Cancer of the pancreas is more common in men than in women. Men are more likely to smoke than women. [pathology.jhu.edu]

Upper Gingival Carcinoma

common in African Americans Gender – more common in men Religious background – more common in Ashkenazi Jews Chronic pancreatitis Diabetes Obesity Diet – diets high in meats [foxnews.com]

[…] factors which may increase the risk of pancreatic cancer include: Cigarette smoking Age – over 80 percent of pancreatic cancers develop between the ages of 60 and 80 Race – more [foxnews.com]

Lumbar Spondylosis

This mutation is rarely found in the general population but is more common in young Ashkenazi Jews with colorectal cancer. [emedicine.medscape.com]

One third of Ashkenazi Jewish individuals who meet the criteria for genetic testing of HNPCC have this mutation. [emedicine.medscape.com]

Pediatric Crohn Disease

Crohn disease is more common in whites than in blacks and is rare in Asian and Hispanic children. [emedicine.com]

Rates are higher in people of Jewish descent, particularly Ashkenazi Jews and Jews of middle European origin compared with Sephardic or eastern European Jews. [emedicine.com]

Gaucher Disease

It is more common among Ashkenazi Jews, affecting 1 in 850. Signs and symptoms may appear at any age. [cerezyme.com]

The defective genes are more common among Ashkenazi Jews, occurring in 1 out of every 850 births within this population. [gaucherdisease.org.uk]

Gaucher disease is more common among Jews of Ashkenazi (Eastern European) descent, occurring in approximately 1 in 450 within this population. [gaucherdisease.org]

Cecal Adenocarcinoma

Bloom syndrome is more common in eastern European Ashkenazi Jews. At least 1 in 100 Ashkenazi Jews is a carrier of the disease. [dermnetnz.org]

Founder Effect in Ashkenazi Jews with BS Linkage disequilibrium BS is commoner in the Ashkenazi Jewish than in any other population known; a survey of BS in Israel in 1977 [academic.oup.com]

It appears to be slightly more common in males than females. What are the signs and symptoms of Bloom syndrome? [dermnetnz.org]

Benign Adult Familial Myoclonic Epilepsy

Certain ethnic groups are at risk for this disorders; Gaucher type I is commonly found in Ashkenazi Jews (incidence of 1 in 2,500 births), while type III is more common in [neuroweb.us]

Niemann-Pick Disease

Niemann-Pick disease [ Wikipedia ], a lysosomal storage disease, is more common among some ethnic groups, including Ashkenazi Jews, North Africans, Arabs, and Turks. [snpedia.com]

[…] the liver Niemann-Pick disease Metabolism A rapidly progressive AR storage disease with progressive neurologic damage due to sphingomyelinase deficiency; NPD type A is AR, more [medical-dictionary.thefreedictionary.com]

Inflammatory Bowel Disease Type 1

It occurs about equally in both sexes, often runs in families, and seems to be more common among Ashkenazi Jews. [merckmanuals.com]

Ulcerative colitis is slightly more common in women than in men. [emedicine.medscape.com]

However, it is most common among people of Northern European and Anglo-Saxon descent. [merckmanuals.com]

Ulcerative Colitis

UC can develop in a person of any race, but it’s more common in Caucasians. [healthline.com]

If you’re an Ashkenazi Jew, you have a greater chance of developing the condition than most other groups. [healthline.com]

Tay-Sachs Disease

Some of the studies appeared to suggest that the disease was more common among Ashkenazi Jews, which has since been shown to be false, leading to the stigmatization of these [news-medical.net]

The genetic disorder is more common in Ashkenazi Jews, a group of people whose heritage is from central and eastern Europe. [healthdirect.gov.au]

common in Ashkenazi (European) Jews (carrier frequency, 1 in 27) than in general populations (carrier frequency, 1 in 250). 4 Affected babies appear normal at birth, then [mja.com.au]

Maple Syrup Urine Disease

The disease is also more common among Ashkenazi Jews, with roughly 1 in 50,000 affected by MSUD type 1B. How is Maple Syrup Urine Disease Type 1B treated? [jscreen.org]

MSUD type 1B is more than twice as common in Ashkenazi Jews as in the general population. Type 1A is more common in Old Order Mennonites. [snpedia.com]

Glycogen Storage Disease Type 7

It is more common in Ashkenazi Jews. [ 1 ] Presentation Infantile-onset form [ 2 ] The cases reported have presented under the age of 1 year. [patient.info]

Males appear to be affected more commonly than females. [patient.info]