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94 Possible Causes for Most Common Autosomal Dominant Spastic Paraplegia

  • Autosomal Dominant Spastic Paraplegia Type 4

    Autosomal dominant hereditary spastic paraplegia 4 linked to chromosome 2p (SPG4) is the most common form of autosomal dominant hereditary spastic paraplegia.[ncbi.nlm.nih.gov] OBJECTIVES The primary objective of this protocol is to study the natural history of the most common forms of autosomal dominant hereditary spastic paraplegia.[clinicaltrials.gov] spastic paraplegia autosomal dominant 2; FSP2 See More Categories: Spastic paraplegia 4 (SPG4) is the most common type of hereditary spastic paraplegia (HSP) inherited in[rarediseases.info.nih.gov]

  • X-linked Parkinsonism-Spasticity Syndrome

    Spastic paraplegia 13, autosomal dominant (SPG13) is caused by mutations in the HSPD1 gene 10.[centogene.com] Homozygous ALDH18A1 mutations were identified as segregating in three independent families with autosomal dominant hereditary spastic paraplegia, as well as in two sporadic[centogene.com] ATL1 mutations have been confirmed as the most common cause of early-onset SPG (SPG3A), accounting for approximately 30%-50% of all AD SPG with onset before age of ten 6.[centogene.com]

  • Hereditary Spastic Paraplegia

    Marked differences were found in the frequencies of hereditary ataxia subtypes compared with other countries, while those of the most common autosomal dominant-hereditary[ncbi.nlm.nih.gov] SPG3A, which is the second most common type of autosomal dominant hereditary spastic paraplegia (HSP), is caused by mutations in the atlastin GTPase 1 gene, ATL1.[ncbi.nlm.nih.gov] Spastic paraplegia 4 (SPAST) is the most common type of uncomplicated autosomal dominant HSP (40% of such cases), and spastic paraplegia 3A (ATL1) is the second most common[ncbi.nlm.nih.gov]

  • Pure Hereditary Spastic Paraplegia

    The most common shorthand of "Autosomal Dominant Pure Hereditary Spastic Paraplegia" is ADPHSP.[acronymsandslang.com] Spastic paraplegia 13, autosomal dominant (SPG13) is caused by mutations in the HSPD1 gene 10.[centogene.com] ADPHSP as abbreviation means "Autosomal Dominant Pure Hereditary Spastic Paraplegia". Q: A: What is shorthand of Autosomal Dominant Pure Hereditary Spastic Paraplegia?[acronymsandslang.com]

  • Autosomal Dominant Spastic Paraplegia Type 31

    Mutations in this gene are regarded as being the third most common cause of autosomal dominant hereditary spastic paraplegia, with an incidence of 2-6 %.[ediss.uni-goettingen.de] OBJECTIVES The primary objective of this protocol is to study the natural history of the most common forms of autosomal dominant hereditary spastic paraplegia.[clinicaltrials.gov] […] to 16 genes that cause hereditary spastic paraplegia ( HSP ) that is inherited in an autosomal dominant pattern.[invitae.com]

  • Autosomal Dominant Spastic Paraplegia Type 29

    Most common symptoms of SPASTIC PARAPLEGIA 29, AUTOSOMAL DOMINANT; SPG29 Autosomal dominant inheritance Seizures Hearing impairment Sensorineural hearing impairment Vomiting[mendelian.co] spastic paraplegia autosomal dominant 2; FSP2 See More Categories: Spastic paraplegia 4 (SPG4) is the most common type of hereditary spastic paraplegia (HSP) inherited in[rarediseases.info.nih.gov] These genes include the most common causes of autosomal dominant, autosomal recessive, and X-linked HSP.[invitae.com]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    Hereditary spastic paraplegia (HSP) : Although dominant autosomal trait is the most common one, recessive and X-linked inheritance exist.[neuroweb.us] Progressive, spastic weakness in the distal legs with mild or absent sensory or sphincter involvement is characteristic.[neuroweb.us]

  • Amyotrophic Lateral Sclerosis

    Pathogenic mutations in the KIF5A-SPG10 gene, encoding the kinesin HC5A, can be associated with autosomal dominant hereditary spastic paraplegia (ADHSP).[ncbi.nlm.nih.gov] Peripheral neuropathy, distal upper limb amyotrophy, and cognitive decline are the most common additional clinical features.[ncbi.nlm.nih.gov]

  • Infantile-Onset Ascending Hereditary Spastic Paralysis

    Spastic paraplegia 13, autosomal dominant (SPG13) is caused by mutations in the HSPD1 gene 10.[centogene.com] Homozygous ALDH18A1 mutations were identified as segregating in three independent families with autosomal dominant hereditary spastic paraplegia, as well as in two sporadic[centogene.com] ATL1 mutations have been confirmed as the most common cause of early-onset SPG (SPG3A), accounting for approximately 30%-50% of all AD SPG with onset before age of ten 6.[centogene.com]

  • Primary Lateral Sclerosis

    The main differential consideration is hereditary spastic paraplegia (HSP).[ncbi.nlm.nih.gov] HSP can show autosomal dominant, recessive, or x-linked inheritance, and to date over 50 different genes have been described.[ncbi.nlm.nih.gov] The most common dominant for is due to mutations in SPG4 (spastin), accounting for 30–40% of families, and the most common recessive mutation in SPG11 (spatacsin), accounting[ncbi.nlm.nih.gov]

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