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159 Possible Causes for Most Patients Have Adult Onset of Symptoms, Mutation in the CALM2 Gene, T Wave Alternans

  • Long QT Syndrome

    […] case with type 3 congenital long QT syndrome, who exhibited a sudden paradoxical QT-interval prolongation during a progressive increase in heart rate, which exacerbated T-wave[ncbi.nlm.nih.gov] RESULTS: A novel de novo CALM2 mutation (D132H) was discovered by candidate gene screening in a male infant with prenatal bradycardia born to healthy parents.[ncbi.nlm.nih.gov] U wave was observed in 86 episodes (56.9%), among that in 69 episodes, the U/T wave ratio was 1. Macro T wave alternans was observed in 4 patients.[ncbi.nlm.nih.gov]

    Missing: Most Patients Have Adult Onset of Symptoms
  • Ventricular Arrhythmia

    T wave alternans in idiopathic long QT syndrome. J Am Coll Cardiol. 1994;23(7):1541–6. PubMed CrossRef Google Scholar 50. Napolitano C, Priori SG, Schwartz PJ.[doi.org] LQT15LQT15 is caused by heterozygous mutations in the CALM2 (Calmodulin 2) gene (114182) on chromosome 2p21.[en.wikipedia.org] […] morphology, 8 9 T-wave alternans, 10 an abnormal slope of the relation of QT interval to cycle length (QT/RR interval slope), 11 12 13 and an abnormal QRST isoarea distribution[doi.org]

    Missing: Most Patients Have Adult Onset of Symptoms
  • Long QT Syndrome 13

    alternans [1 point] Notched T wave in 3 leads [1 point] Low heart rate for age [0.5 point] Clinical history Syncope [2 points] With stress [1 point] Without stress [1 point[athletesheart.org] This prompted candidate-gene screening in a cohort of 82 LQTS genotype-negative patients. Two more patients were carriers of either CALM1 or CALM2 mutations.[smw.ch] T-wave alternans and sinus pause corroborates this further.[ecgwaves.com]

    Missing: Most Patients Have Adult Onset of Symptoms
  • Long QT Syndrome 10

    T-wave alternans and sinus pause corroborates this further.[ecgwaves.com] This prompted candidate-gene screening in a cohort of 82 LQTS genotype-negative patients. Two more patients were carriers of either CALM1 or CALM2 mutations.[smw.ch] wave alternans - 1 point Notched T wave in at least 3 leads - 1 point Low heart rate for age (children) - 0.5 points Syncope (one cannot receive points both for syncope and[checkorphan.org]

    Missing: Most Patients Have Adult Onset of Symptoms
  • Glycogen Storage Disease due to Muscle Phosphorylase Kinase Deficiency

    The onset of symptoms can occur in childhood or adulthood; most patients have adult onset.[rarediseases.org] There are autosomal recessive forms of GSD IX (caused by mutations in PHKB, PHKG1, PHKG2, CALM1, CALM2, and CALM3 ), a X-linked liver form (caused by mutations in PHKA2 ),[bmcmedgenet.biomedcentral.com] Notably, some individuals with phosphorylase kinase deficiency in muscle do not have any obvious symptoms.[rarediseases.org]

    Missing: T Wave Alternans
  • Torsades De Pointes

    U wave was observed in 86 episodes (56.9%), among that in 69 episodes, the U/T wave ratio was 1. Macro T wave alternans was observed in 4 patients.[ncbi.nlm.nih.gov] […] reversed asymmetry (20.0% vs 0%, P .001), and T-wave alternans (35.0% vs 0%, P .001).[ncbi.nlm.nih.gov] T-wave alternans and sinus pause corroborates this further.[ecgwaves.com]

    Missing: Most Patients Have Adult Onset of Symptoms Mutation in the CALM2 Gene
  • Nonsustained Ventricular Tachycardia

    We examined whether T-wave alternans (TWA) level is correlated with nonsustained ventricular tachycardia (NSVT) incidence in association with PCI in patients with acute ST-segment[ncbi.nlm.nih.gov] OBJECTIVE: Microvolt T-wave Alternans (TWA) is associated with abnormal repolarization and predicts arrhythmic mortality in patients with previous myocardial infarction (MI[ncbi.nlm.nih.gov] Alternans T-wave alternans (TWA) is a test that is thought to reflect dispersion of repolarization and has been shown to predict VT inducibility and future arrhythmic events[clinicalgate.com]

    Missing: Most Patients Have Adult Onset of Symptoms Mutation in the CALM2 Gene
  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 2

    Mean T-wave alternans (TWA) was 25 1.4 µV in CPVT patients vs. 31 2.0 µV in controls (P 0.05).[ncbi.nlm.nih.gov] […] that have been discovered and only represent a small percentage of CPVT cases are TRDN (encoding triadin) and CALM1 (encoding calmodulin). 5,6 Mutations in the CALM2 gene[doi.org] Eloff -- Diagnostic Electrocardiography / Preben Bjerregaard -- Microvolt T Wave Alternans: Mechanisms and Implications for Prediction of Sudden Cardiac Death / Florian Rader[worldcat.org]

    Missing: Most Patients Have Adult Onset of Symptoms
  • Ventricular Tachycardia

    Like T-wave alternans, the test is not widely used, with the exception of longitudinal evaluation of patients with suspected ARVC.[emedicine.com] Chow T, Kereiakes DJ, Bartone C, et al. Prognostic utility of microvolt T-wave alternans in risk stratification of patients with ischemic cardiomyopathy .[ncbi.nlm.nih.gov] Other noninvasive tests, such as T-wave alternans, signal-averaged ECG, and heart rate variability, do not provide diagnostic confirmation, but might be helpful in defining[revespcardiol.org]

    Missing: Most Patients Have Adult Onset of Symptoms Mutation in the CALM2 Gene
  • Ventricular Fibrillation

    RESULTS: Frequencies of history of syncope and spontaneous type 1 ECG, r-J interval in V1, QRS duration in V6, and LAS40, Tpeak-Tend dispersion, and max T-wave alternans were[ncbi.nlm.nih.gov] In this type of test, slight changes in your electrocardiogram’s T wave are monitored during gentle exercise.[healthline.com] wave alternans 1 Notched T waves in three leads 1 Low heart rate for age (resting rate below second percentile 0.5 Clinical History Syncope With stress 2 Without stress 1[emedicine.medscape.com]

    Missing: Most Patients Have Adult Onset of Symptoms Mutation in the CALM2 Gene