Motor Delay: Causes & Reasons

Possible Causes for Motor Delay

His developmental assessment revealed gross motor delay with head control and sitting achieved 1 month later than usual. [ncbi.nlm.nih.gov]

delay. [ncbi.nlm.nih.gov]

delay Faltering growth Pompe disease (GSD-II) ++ ++ ++ ++ + + + ++ + Cori-Forbes disease (GSD-III) ++ – +/- +/- – ++ +/- – + Anderson disease (GSD-IV) + + + + – ++ + – + [ncbi.nlm.nih.gov]

Central Core Disease

A 10-month-old boy presented with gross motor delay and muscle weakness, especially in both lower limbs. At age 5, he developed lordosis, talipes, and planovalgus. [ncbi.nlm.nih.gov]

[…] developmental delay 2. [pedbase.org]

CCD typically presents in infancy with hypotonia and motor developmental delay and is characterized by predominantly proximal weakness pronounced in the hip girdle; orthopaedic [ncbi.nlm.nih.gov]

Rigid Spine Syndrome

[…] infiltration Primary 12 Motor delay 11 200 Myo Normal Patient did not consent Muscle wasting, hypointensity and fibro-fatty infiltration Primary 15 Motor delay 9 187 Myo [ncbi.nlm.nih.gov]

fibro fatty infiltration Primary 15 Motor delay 8 230 Myo N Not agreed Muscle wasting, hypointensity, fibro fatty infiltration Primary + 6 Motor delay 10.4 123 Myo N Multicore [brieflands.com]

delay 0001270 Muscular dystrophy 0003560 Muscular hypotonia Low or weak muscle tone 0001252 Nasal speech Nasal voice 0001611 Nocturnal hypoventilation 0002877 Nonprogressive [rarediseases.info.nih.gov]

Congenital Muscular Dystrophy with Integrin Alpha-7 Deficiency

delay ; Muscle weakness ; Myopathy ; Neonatal hypotonia ; Scoliosis ; Skeletal muscle atrophy Associated Genes ITGA7 Mouse Orthologs Itga7 Source OMIM:613204 (names, synonyms [mousephenotype.org]

motor development. [egl-eurofins.com]

[…] weakness and atrophy, motor development regress, scoliosis and respiratory insufficiency. [orpha.net]

Mowat-Wilson Syndrome

Generalized increase in muscle cell size 0003720 Happy demeanor 0040082 Hypoplasia of the corpus callosum Underdevelopment of part of brain called corpus callosum 0002079 Motor [rarediseases.info.nih.gov]

delay 0001270 Pectus carinatum Pigeon chest 0000768 Pectus excavatum Funnel chest 0000767 Prominent nasal tip Large nasal tip Large tip of nose Prominent tip of nose Pronounced [rarediseases.info.nih.gov]

Congenital Muscular Dystrophy Type 1A

In all the cases, motor milestones were delayed. Two patients could sit, but not stand and walk. [pediatricneurosciences.com]

Motor development is often delayed and limited. Most affected infants can sit unsupported and some can stand without assistance. [rarediseases.info.nih.gov]

The patient 3 was a 7-month-old girl who presented to our hospital with complaints of developmental motor delays. Intellectual and speech development was normal. [pediatricneurosciences.com]

Muscular Dystrophy-Dystroglycanopathy Type B6

Congenital muscular dystrophies ( CMD ) are a heterogeneous group of autosomal recessive myopathies presenting at birth with hypotonia, delayed motor development, and early [radiopaedia.org]

Congenital muscular dystrophy type 1A (MDC1A) is an autosomal recessive disorder characterized by hypotonia, elevated serum creatine kinase level, delayed motor milestones [yonsei.pure.elsevier.com]

In all the cases, motor milestones were delayed. Two patients could sit, but not stand and walk. [pediatricneurosciences.com]

Congenital Myopathy with Excess of Thin Filaments

delay; skeletal muscle weakness; respiratory weakness; drooling; speech impairment; maximum motor function achieved: climb 4 stairs with handrail; electron microscopy result [catalog.coriell.org]

Motor milestones are typically delayed. Affected infants are usually hypotonic and display delayed motor development. [mhmedical.com]

Most common symptoms of SEVERE CONGENITAL NEMALINE MYOPATHY Low-set ears Flexion contracture Motor delay Skeletal muscle atrophy Dysphagia More info about SEVERE CONGENITAL [mendelian.co]

Multicore Myopathy with External Ophthalmoplegia

Related symptoms: Motor delay Muscular hypotonia Myopathy Talipes equinovarus Elevated serum creatine phosphokinase SOURCES: ORPHANET More info about CENTRAL CORE DISEASE [mendelian.co]

[…] in infancy ; Generalized muscle weakness ; High palate ; Hydrops fetalis ; Increased connective tissue ; Increased variability in muscle fiber diameter ; Joint laxity ; Motor [mousephenotype.org]

Severity of symptoms are variable Symptoms - Myopathy congenital multicore with external ophthalmoplegia * Neonatal hypotonia * Delayed motor development * Muscle weakness [checkorphan.org]

Barth Syndrome

The muscle weakness often causes delay of motor skills such as crawling and walking. [malacards.org]

Muscles are weak and affected babies are often slow to sit, walk or run (called 'delayed motor milestones' or 'motor delay'). [contact.org.uk]

Significant clinical problems may include congestive heart failure, life-threatening bacterial infections, gross motor delay, risk of fatal arrhythmias, short stature through [mitoaction.org]

Autosomal Recessive Centronuclear Myopathy

[…] gross motor development Delayed motor skills 0002194 Difficulty walking Difficulty in walking 0002355 EMG: myopathic abnormalities 0003458 Generalized hypotonia Decreased [rarediseases.info.nih.gov]

motor milestones and cardiomyopathy (less commonly). [rarediseases.info.nih.gov]

Early onset of symptoms with hypotonia, motor developmental delay, proximal muscle weakness, and a stable course were common clinical features in the cohort. [institut-myologie.org]

Déjerine-Sottas Disease

[…] weakness, delayed motor development, extremely slow nerve conduction (< 10-12 m/s), areflexia and foot deformity. [orpha.net]

The patient showed delayed motor development. She walked for the first time with support at the age of 2 years. Scoliosis developed at age 4 years. [ncbi.nlm.nih.gov]

All had delayed motor development. Four children presented with delayed motor milestones, hypotonia, and/or hip dysplasia. [ncbi.nlm.nih.gov]

Dermatosparaxis

delay, Myopia, Premature birth, Downslanted palpebral fissures (Downward slanting of the opening between the eyelids), Drooping lower lip, Frontal open bite, Bleeding gums [xpertdox.com]

Micrognathia Abnormal facial shape Muscular hypotonia Motor delay Depressed nasal bridge Epicanthus Wide nasal bridge And another 79 symptoms. [mendelian.co]

motor development Osteopenia Hirsutism Tooth abnormalities Refractive errors (myopia, astigmatism) Strabismus Minimal criteria suggestive for dEDS: –Major criterion (1): [edstoday.org]

Congenital Muscular Dystrophy due to LMNA Mutation

Diseases related with Motor delay and Congenital muscular dystrophy In the following list you will find some of the most common rare diseases related to Motor delay and Congenital [mendelian.co]

Since delay of motor skill acquisition may be a presenting symptom of CMD, onset of manifestations before age two years may be a reasonable diagnostic criterion, although [invitae.com]

We describe a 22-month-old girl with axial muscle and diaphragmatic weakness as well as motor developmental delay without mental retardation. [pubfacts.com]

Pompe Disease

Cardiomegaly is not typically seen, but progressive muscle weakness resulting in motor delays, swallowing difficulties, and respiratory insufficiency usually occurs as in [centogene.com]

The presentation may include one or a few of the following: muscle weakness/hypotonia motor delay hypertrophic cardiomyopathy hepatomegaly macroglossia failure to thrive respiratory [radiopaedia.org]

Patients older than 6 months present with motor delays and/or slowly progressive muscle weakness. Death results from ventilatory failure in early childhood. [emedicine.medscape.com]

Usher Syndrome Type 1K

Human phenotypes related to Usher Syndrome, Type Ik: 30 # Description HPO Frequency Orphanet Frequency HPO Source Accession 1 motor delay 30 HP:0001270 2 rod-cone dystrophy [malacards.org]

delay Ear malformation Vestibular dysfunction IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information [ncbi.nlm.nih.gov]

Affiliated tissues include bone, and related phenotypes are motor delay and rod-cone dystrophy Disease Ontology : 12 An Usher syndrome type 1 that has material basis in variation [malacards.org]

Pitt-Hopkins Syndrome

Pitt-Hopkins-like syndrome-2 Similar to Type 1, these children may have no motor delays or mild delays. Other symptoms are similar to PTHS. [childrens.com]

delay, motor incoordination, ocular anomalies, constipation, seizures, typical behavior and subtle brain abnormalities. [genecards.org]

In contrast to patients with Pitt-Hopkins syndrome, PTHSL2 patients present with normal or only mildly to moderately delayed motor milestones. [uniprot.org]

Lesch-Nyhan Syndrome

Infants with Lesch Nyhan syndrome appear normal at birth but motor delay and low-muscle tone become obvious within the first few months of life. [contact.org.uk]

The authors report two brothers who presented with motor delay and stiffness. The elder boy had auto-mutilation of lips and fingers. [ncbi.nlm.nih.gov]

Ataxic Cerebral Palsy

Hypotonia: Children who become hypotonic face the following problems- delays in motor skill development difficulties with speech lack of attention The delay in motor skill [speechtherapy.ygoy.com]

delay 0001270 Showing of 9 | Last updated: 12/1/2018 If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this [rarediseases.info.nih.gov]

Most were hypotonic docile infants with delayed speech and motor skills, particularly those with posterior fossa abnormality. [ncbi.nlm.nih.gov]

Hypomyelinating Leukodystrophy Type 6

CASE REPORT: An 8-year-old child with history of delayed motor development, tremor, dysathria, ataxia, nystagmus, cognitive deficit and dystonia with pattern of hypomielination [ncbi.nlm.nih.gov]

Early-Onset Myopathy with Fatal Cardiomyopathy

motor development, generalized muscle weakness involving also the facial muscles, pseudohypertrophy of lower limb muscles, and joint contractures, associated with childhood [orpha.net]

Search for a rare disease Early-onset myopathy with fatal cardiomyopathy Disease definition A rare genetic neuromuscular disease characterized by neonatal or infancy onset of delayed [orpha.net]

X-linked Mental Retardation Type Cabezas

Enlarged male breast 0000771 Motor delay 0001270 Pes planus Flat feet Flat foot [ more ] 0001763 Percent of people who have these symptoms is not available through HPO Abnormality [rarediseases.info.nih.gov]

Speech and language difficulties Speech delay [ more ] 0000750 Distal lower limb amyotrophy 0008944 Gait ataxia Inability to coordinate movements when walking 0002066 Gynecomastia [rarediseases.info.nih.gov]

[…] development Impaired speech development Language delay Language delayed Language development deficit Late-onset speech development Poor language development Speech and language delay [rarediseases.info.nih.gov]

Sengers Syndrome

Motor delay MedGen UID: 381392 •Concept ID: C1854301 • Finding A type of Developmental delay characterized by a delay in acquiring motor skills. [ncbi.nlm.nih.gov]

He had mild motor developmental delay. [content.iospress.com]

Other reported features include nystagmus, strabismus, hypotonia, hyporeflexia and delayed motor development. [en.wikipedia.org]

Ehlers-Danlos Syndrome Kyphoscoliotic Type 2

With rare exceptions, motor developmental delay and reduced motor strength are common features in childhood, although muscle weakness typically improves during childhood [ [ncbi.nlm.nih.gov]

[…] developmental delay, myopathy, and hearing impairment. [ncbi.nlm.nih.gov]

[…] developmental delay, myopathy, and hearing impairment [Baumann et al 2012, Giunta et al 2018a]. [ncbi.nlm.nih.gov]

Autosomal Dominant Mental Retardation Type 1

The observed phenotype includes ID, language impairments, infantile hypotonia and gross motor delay, behavioral problems, autistic features, dysmorphic facial features (pinnae [ohsu.pure.elsevier.com]

language impairment; impulsiveness; hyperactivity; seeking behavior; mental retardation; motor delay; short attention span; short stature; seizures; ataxia; feeding difficulties [coriell.org]

These tend to include: developmental delay and/or regression motor delay, balance concerns language impairment muscle weakness infantile feeding difficulties seizures (seen [2q23.org]

3-Methylglutaconic Aciduria Type 1

The nonprogressive myopathy predominantly affects the proximal muscles, and results in early motor delays. [ncbi.nlm.nih.gov]

Deflazacort vs prednisone/prednisolone for maintaining motor function and delaying loss of ambulation: A post hoc analysis from the ACT DMD trial. [scielo.org.pe]

Motor delay Abnormality of the respiratory system Recurrent bronchitis Constitutional symptom Exercise intolerance Fatigue Ear malformation Macrotia Growth abnormality Failure [ncbi.nlm.nih.gov]

Nemaline Myopathy Type 9

Major motor milestones are delayed, but independent ambulation is achieved. [emedicine.medscape.com]

In rare cases, delayed attainment of motor milestones may be the first sign of the disorder. [rarediseases.org]

Among the 28 patients, 15 presented mild hypotonia and chronic limb weakness during the neonatal period, with delayed motor milestone in a few cases. [spandidos-publications.com]

5q14.3 Microdeletion Syndrome

(speech and motor delays), intellectual disabilities, distinctive facial features, and brain abnormalities This chromosomal anomaly is usually known to develop from sporadic [dovemed.com]

Description 5q31.3 microdeletion syndrome is a condition characterized by severely delayed development of speech and motor skills, such as walking. [medlineplus.gov]

[…] q14.3 is missing/deleted Some individuals with this deletion may have only mild features, while others may have severe findings that can include growth and developmental delays [dovemed.com]

Antenatal-Onset Multicore Myopathy with Arthrogryposis

 Less movement of limbs  Baby is alert, but less motor activity.  Delayed motor development.  Able to walk but with frequent falls History : 1. [dnbpediatrics.com]

Causes - Minicore myopathy- antenatal onset- with arthrogryposis Other Possible Causes of these Symptoms * Delayed motor development * High arched palate * Long head * Low [checkorphan.org]

Major motor milestones are delayed, but independent ambulation is achieved. [emedicine.medscape.com]

Chromosome 22q13.3 Deletion Syndrome

Motor delay is also common and issues with toilet training are also common. Individuals may also experience sleep disorders and feeding problems related to the syndrome. [fdna.health]

These symptoms could include global developmental delay/intellectual disability, motor skills deficits, delayed or absent speech, autism spectrum disorder and minor dysmorphic [childrenshospital.org]

Other common characteristics are behavioral issues including autism spectrum disorder or autistic-like traits, decreased perception of pain, motor delays, sleep disorders [rarediseases.org]