Create issue ticket

14 Possible Causes for Multifocal Epileptiform Spikes, Variable Psychomotor Retardation

  • West Syndrome

    […] clinical manifestations such as hypotonia, psychomotor retardation, and feeding difficulties.[ncbi.nlm.nih.gov] Leigh syndrome (LS) (sub-acute necrotizing encephalomyelopathy) is characterized by symmetric brain lesions occurring mainly in the basal ganglia and associated with variable[ncbi.nlm.nih.gov]

  • Myoclonic-Astatic Epilepsy

    retardation mainly affecting speech.[ipfs.io] Boys (74%) are more often affected than girls (Doose and Baier 1987a). [2] Prognosis Epilepsy with myoclonic-astatic seizures has a variable course and outcome.[ipfs.io] […] to 3-Hz spike-waves and polyspike patterns with a 4- to 7-Hz background. 84% of affected children show normal development prior to seizures; the remainder show moderate psychomotor[ipfs.io]

  • Early Infantile Epileptic Encephalopathy Type 26

    The majority of affected patients had mild to severe psychomotor retardation. Hypotonia, hypertonia and dystonia were common as well [ 9 ].[bmcmedgenet.biomedcentral.com] Diagnosis The interictal EEG consists of multifocal epileptiform discharges and background slowing.[intechopen.com] The seizure semiology was variable, including focal seizures, clonic seizures, tonic-clonic seizures, epileptic spasms, myoclonic and absence seizures, etc. [ 9 , 12 ].[bmcmedgenet.biomedcentral.com]

  • Early Infantile Epileptic Encephalopathy Type 2

    […] degree of psychomotor delay and cognitive impairment, ranging from mild to severe mental retardation [23].[journals.plos.org] Diagnosis The interictal EEG consists of multifocal epileptiform discharges and background slowing.[intechopen.com] […] members of the same family: onset of seizures is between 6 and 36 months, the patients present with a combination of febrile and afebrile seizures of various types and a variable[journals.plos.org]

  • X-Linked Partial Corpus Callosum Dysgenesis

    Milder forms are associated with variable psychomotor retardation depending on the pathology. Diabetes insipidus is frequent in these patients.[neuropathology-web.org] Routine EEG revealed diffuse bilateral cerebral dysfunction with paroxysmal bursts of high-voltage slow waves and multifocal epileptiform discharges, right more than left.[raredisorders.imedpub.com] Video EEG showed moderate generalized slowing with superimposed focal right hemispheric slowing and nearly continuous high-amplitude slow spikes-and-slow wave complexes maximal[raredisorders.imedpub.com]

  • Early Infantile Epileptic Encephalopathy Type 28

    SCAR12 is additionally characterized by onset of generalized seizures in infancy, and delayed psychomotor development with mental retardation.[selfdecode.com] Diagnosis The interictal EEG consists of multifocal epileptiform discharges and background slowing.[intechopen.com] Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement[selfdecode.com]

  • Progressive Epilepsy-Intellectual Disability Syndrome, Type Finnish

    […] and ranging from seizures and moderate psychomotor retardation to mild autistic features with speech and language delay Treatment: Supportive care Congenital disorders of[merckmanuals.com] […] complexes.[ 16 ] Multifocal, predominantly posterior, epileptiform discharges appear in addition to the generalized bursts.[thieme-connect.com] Type III (intermediate form; 609241) Onset: Childhood Urine metabolites: Oligosaccharides and O-linked sialopeptides Clinical features: Intermediate between types I and II; variable[merckmanuals.com]

  • Early Infantile Epileptic Encephalopathy Type 14

    The majority of affected patients had mild to severe psychomotor retardation. Hypotonia, hypertonia and dystonia were common as well [ 9 ].[bmcmedgenet.biomedcentral.com] These burst suppression patterns with associated interictal multifocal spikes and polyspikes in association with the specific neonatal clinical epileptiform activity must[frontiersin.org] The seizure semiology was variable, including focal seizures, clonic seizures, tonic-clonic seizures, epileptic spasms, myoclonic and absence seizures, etc. [ 9, 12 ].[bmcmedgenet.biomedcentral.com]

  • Kahrizi Syndrome

    The diagnostic criteria of this novel inborn error of glycosylation, SRD5A3-CDG, are psychomotor retardation, nystagmus, visual impairment due to variable eye malformations[academic.oup.com] EEG findings were available for 11 of the 13 patients and showed generalized (3), bilateral (1), multifocal (1), and focal (1) epileptiform discharges and were normal in 2[ng.neurology.org] This novel inborn error of glycosylation presents with psychomotor retardation, cerebellar ataxia, nystagmus, visual impairment, variable congenital eye malformations, ichthyosiform[academic.oup.com]

  • Early Infantile Epileptic Encephalopathy with Suppression-Burst

    The majority of affected patients had mild to severe psychomotor retardation. Hypotonia, hypertonia and dystonia were common as well [ 9 ].[bmcmedgenet.biomedcentral.com] Diagnosis The interictal EEG consists of multifocal epileptiform discharges and background slowing.[intechopen.com] The seizure semiology was variable, including focal seizures, clonic seizures, tonic-clonic seizures, epileptic spasms, myoclonic and absence seizures, etc. [ 9, 12 ].[bmcmedgenet.biomedcentral.com]

Further symptoms