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22 Possible Causes for Multifocal Spike-and-Slow-Wave Activity

  • Epilepsy

    waves, multifocal discharges, generalized paroxysmal fast activity, diffuse slowing slow background, generalized spike waves MRI normal normal vermis hypoplasia, cisterna[] (poly)spikes slow background, left temporal slowing, slow generalized spike-wave discharges, diffuse (poly)spikes not available slow background, diffuse slow spike-wave discharges[] waves, PPR irregular generalized spike waves, PPR not specified generalized slow spike waves and runs of fast spikes not specified generalized (poly)spike waves, slow spike[]

  • Unverricht-Lundborg Syndrome

    Neurophysiology shows increased amplitude of multimodal evoked potentials, and marked interictal and ictal generalized spikewave activity on electroencephalography (EEG).[] EEG in patients with sialidosis reveals progressive slowing of background activity with bilateral spike and wave activity, which is photosensitive.[] The EEG background is often moderately slow.[]

  • Lafora Disease

    The EEG register is slow in background activity and presents multifocal paroxystic discharges of spike and spike waves.[] The EEG records show a slowing of background activity and bursts of spike and wave which are generalised, multifocal, and often sensitive to intermittent luminous stimulation[]

  • Benign Adult Familial Myoclonic Epilepsy

    Note the high-amplitude, disorganized slow activity with multifocal spikes with an electrodecremental response.[] Slow spike and wave of Lennox-Gastaut syndrome (LGS). Thirty-six-year-old man with LGS. Note the bilaterally synchronous 1.5- to 2-Hz spike-and-wave discharges. Fig. 9.[]

  • Early Infantile Epileptic Encephalopathy Type 6

    At onset, EEG is usually normal but later spikes or poly spike-waves with a slowing of background activity are noted as well as multifocal discharges.[] […] discharges and slowed background activity.[] By the second to fifth year of age, generalized spike-and-wave and multifocal discharges are seen. Activation.[]

  • Myoclonic-Astatic Epilepsy

    ; LTG, lamotrigine; M, myoclonic seizure; MA, myoclonic-astatic seizure; MF, multifocal spikes; PHT, phenytoin; PSW, diffuse polyspike and wave complexes; SBA, slowing of[] […] background activity consisting mainly of theta rhythm; SW, diffuse spike and wave complexes T, tonic seizure; TC: tonic-clonic seizure; VPA, valproic acid; ZNS, zonisamide[] […] period (years) 10 12 4 5 A, absence seizure; CBZ, carbamazepine; CLB, clobazam; CPS, complex partial seizure; CZP, clonazepam; DA, drop attack; ESM, ethosuximide; FS, focal spikes[]

  • Paroxysmal Exertion-Induced Dyskinesia

    , chaotic pattern of spikes and slow wave, High-amplitude activity, esp. over posterior (Need to lower the sensitivity) Classically a/w electrodecremental seizures (high amplitude[] […] generalized epilepsy in sleep, or at onset of a GTC Associated with tonic seizures More common in pts with developmental delay b/w 6 mo-2 yrs (rare after 4 yrs) Irregular, multifocal[]

  • Angelman Syndrome

    (a) Generalized burst of spike and spike waves with high amplitude, prevalent in the anterior regions, (b) Very slow background activity mixed with multifocal spikes.[] multifocal spikes and sharp waves of moderate amplitude.[] With time the EEG pattern changed showing a very slow background activity mixed with multifocal spikes (Fig. 2b ). Figure 2 EEG at different ages.[]

  • Lennox-Gastaut Syndrome

    Interictal EEG showed findings characteristic of LGS: generalized slow spike-wave complexes, multifocal sharp waves, generalized polyspikes and paroxysmal fast activity during[]

  • Continuous Spike-and-Slow-Waves during Sleep

    Multifocal spikes and sharp and slow waves are also present. Intervals of attenuation can occur with and without clinical myoclonic activity or flexor spasms.[] Epileptiform Activity Only spikes, sharps, and spike and wave complexes. Spike 20-80 ms. Often followed by a low voltage slow potential (200 ms).[] Note the high-amplitude, disorganized slow activity with multifocal spikes with an electrodecremental response.[]

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