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360 Possible Causes for Multifocal Spikes, Slow-Frequency High-Amplitude Waves with High-Frequency Polyspikes, Variable Psychomotor Retardation

  • West Syndrome

    […] clinical manifestations such as hypotonia, psychomotor retardation, and feeding difficulties.[ncbi.nlm.nih.gov] Interictal The background EEG is often highly disorganized with high voltage irregular slow waves intermixed with multifocal spikes and polyspikes, this is termed 'hypsarrhythmia[epilepsydiagnosis.org] The interictal EEG pattern is described as hypsarrhythmic as it is characterised by asynchronous and high-amplitude slow waves and multifocal spikes.[orpha.net]

  • Myoclonic-Astatic Epilepsy

    retardation mainly affecting speech.[ipfs.io] Interictal EEG revealed generalized irregular multiple spikes-and-waves with focal or multifocal accentuations.[ncbi.nlm.nih.gov] ; LTG, lamotrigine; M, myoclonic seizure; MA, myoclonic-astatic seizure; MF, multifocal spikes; PHT, phenytoin; PSW, diffuse polyspike and wave complexes; SBA, slowing of[omicsonline.org]

  • Epilepsy

    […] predominance, and multifocal spike-and-slow waves.[ncbi.nlm.nih.gov] Electroencephalography showed multifocal spikes over the right frontal, temporal and parietal regions. The seizure frequency decreased dramatically after tumorectomy.[ncbi.nlm.nih.gov] Inter-ictal multifocal spikes or sharp and slow waves in nearly all EEGs.[epilepsy.com]

    Missing: Variable Psychomotor Retardation
  • Benign Adult Familial Myoclonic Epilepsy

    Note the high-amplitude, disorganized slow activity with multifocal spikes with an electrodecremental response.[euroformhealthcare.biz] Cortical myoclonus is more commonly encountered in a multifocal form, presenting with multifocal spike discharges.[neupsykey.com] […] with emesis.  Interictal EEG with shifting or multifocal high- amplitude spikes, often with occipital predominance.  Favorable outcome with remission in 1–2 years and normal[slideshare.net]

    Missing: Variable Psychomotor Retardation
  • Generalized Clonic or Tonic-Clonic Seizures

    ‘Contrary to popular folk belief, nothing should be placed in the mouth during the seizure. Severe injury could occur.’ Generalized tonic clonic seizures (grand mal seizures) are the most common and best known type of generalized seizure. They begin with stiffening of the limbs (the tonic phase), followed by jerking[…][epilepsynw.org]

    Missing: Variable Psychomotor Retardation
  • Juvenile Myoclonic Epilepsy

    Juvenile myoclonic epilepsy is a common form of epilepsy mainly characterized by myoclonic jerks, but affected individuals may also experience generalized tonic-clonic seizures and absence seizures. Symptom onset typically occurs around puberty and although the disease persists into adulthood, patients do respond[…][symptoma.com]

    Missing: Variable Psychomotor Retardation
  • Idiopathic Generalized Epilepsy

    Tonic status epilepticus (TSE) in patients with idiopathic generalized epilepsy (IGE) is not well recognized. The objective of this study is to report episodes of TSE in patients with IGE. We retrospectively reviewed the clinical and EEG evaluation of three IGE patients who presented TSE. The three patients had mainly[…][ncbi.nlm.nih.gov]

    Missing: Variable Psychomotor Retardation
  • Early Infantile Epileptic Encephalopathy Type 17

    @inproceedings{Kehrl2014GainoffunctionMI, title {Gain-of-function mutation in Gnao1: A murine model of epileptiform encephalopathy (EIEE17)?}, author {Jason M. Kehrl and Kinshuk Sahaya and Hans M. Dalton and Raelene A. Charbeneau and Kevin T. Kohut and Kristen A Gilbert and Madeline C. Pelz and Jack M. Parent and[…][semanticscholar.org]

    Missing: Variable Psychomotor Retardation
  • Juvenile Absence Epilepsy

    Background activity is often abnormal, reflecting the diffuse or multifocal underlying encephalopathy of symptomatic generalized epilepsy.[reference.medscape.com] Slow spike-and-wave discharges (2.5 Hz). This is an interictal pattern in a child with seizures and developmental delay.[reference.medscape.com] The clinical correlation of generalized spike-and-wave complexes with clinical seizures is not as clear-cut as in typical absence seizures.[reference.medscape.com]

    Missing: Variable Psychomotor Retardation
  • Early Infantile Epileptic Encephalopathy Type 3

    The EEG pattern often shows a suppression-burst pattern with high-voltage bursts of slow waves mixed with multifocal spikes alternating with isoelectric suppression phases[diseaseinfosearch.org] West Syndrome (WS) aka as infantile spasms with hypsarrhythmia, EEG abnormality with asynchronous very high amplitude, irregular, continuous multifocal spike an slow wave[ijponline.biomedcentral.com] ., multifocal spike- and sharp-wave discharges, repetitive paroxysmal activity, unusually low-voltage fast activity, and findings consistent with complex partial seizures[graphyonline.com]

    Missing: Variable Psychomotor Retardation

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