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310 Possible Causes for Multiple Lesions in the White Matter

  • Congenital Muscular Dystrophy

    OBJECTIVES: COL6A and LAMA2 are subtypes of congenital muscular dystrophy. METHODS: Retrospective chart review of clinical findings, spirometry, muscle histology, muscle ultrasound, neuroimaging, and Electromyography (EMG)/Nerve Conduction Study data in genetically confirmed COL6A and LAMA2 subjects. RESULTS: We[…][ncbi.nlm.nih.gov]

  • Delirium

    Imaging studies examining global brain disorders have demonstrated white matter lesions and brain atrophy to be associated with delirium.[doi.org] Multiple studies have identified sedatives, especially benzodiazepines, as modifiable risk factors for delirium.[doi.org]

  • Susac Syndrome

    The magnetic resonance imaging (MRI) of brain revealed multiple small lesions in the white matter in both cerebral hemispheres and at the corpus callosum.[ncbi.nlm.nih.gov] The typical MR imaging findings of multiple focal lesions in the corpus callosum and subcortical white matter can be easily misdiagnosed as multiple sclerosis.[ncbi.nlm.nih.gov] Additionally, non-contrast enhanced brain magnetic resonance imaging showed multiple white matter and callosal lesions consistent with ischemia.[ncbi.nlm.nih.gov]

  • Herpes Zoster

    In contrast, the vasculopathy form is characterized by non-specific ischemia, hemorrhagic lesions, and multiple white matter lesions on MRI [ 16 ].[intechopen.com] The meningoencephalitis form shows no detectable lesions on MRI.[intechopen.com]

  • Primary Progressive Multiple Sclerosis

    […] sclerosis; White matter lesions[ncbi.nlm.nih.gov] BACKGROUND: In primary progressive multiple sclerosis (PPMS), a discrepancy exists between the modest brain white matter (WM) lesion burden and the severity of neurologic[ncbi.nlm.nih.gov] Additional diffusion-weighted imaging revealed restricted diffusion in the white matter lesions with a reduced apparent diffusion coefficient.[ncbi.nlm.nih.gov]

  • Demyelinating Disease

    Lytic infection of oligodendrocytes in the brain leads to their eventual destruction and progressive demyelination, resulting in multiple foci of lesions in the white matter[ncbi.nlm.nih.gov] white matter, medulla, and cervical spine.[omicsonline.org] The MRI may show very dramatic changes with multiple enhancing lesions in the white matter.[ncbi.nlm.nih.gov]

  • Ondine Syndrome

    Brain MRI showed multiple hyperintense lesions at T2 and FLAIR sequences, located in the periventricular and subcortical white matter, right external capsule, thalami, pons[scielo.br] A head CT with no contrast showed several small, hypodense lesions scattered throughout the white matter, with no evidence of intracranial bleeding or midline shift.[scielo.br]

  • Internal Carotid Artery Aneurysm

    MRI performed on day 39 post-coil embolization showed multiple lesions in the white matter with signal hyperintensity on T2-weighted and FLAIR images in the left middle cerebral[ncbi.nlm.nih.gov]

  • Young-Onset Parkinson Disease

    Brain magnetic resonance imaging revealed multiple white matter hyperintense T2-weighted lesions.[ncbi.nlm.nih.gov] Some patients have 2 coincidental diseases, whereas others have a Parkinsonian syndrome symptomatic to demyelinating lesions.[ncbi.nlm.nih.gov]

  • Temporal Lobe Epilepsy

    Opsahl ML, Kennedy PG (2005) Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter. Brain 128: 516–527.[doi.org] Find this article online Opsahl ML, Kennedy PG (2005) Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter.[web.archive.org]

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