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41 Possible Causes for Multiple Myeloma, Thin and Brittle Fingernails

  • Osteopenia and Osteoporosis

    myeloma - Thalassaemia major - AIDS/HIV - Bone fractures (particularly in the spine or hip) Key Topics Covered: 1.[globenewswire.com] Sclerosis, Multiple myeloma, Osteo-genesis imperfect, Organ transplants, Peridontal disease (Peridontitis), Post Polio, Sickle Cell anemia, Skin disorders, Scoliosis, Synthroid[osteopenia3.com] Disorder Specific radiographic clues osteomalacia Looser zones hyperparathyroidism subperiosteal resorption disseminated multiple myeloma focal lytic lesions It can be fairly[rad.washington.edu]

  • Vitamin D Deficiency

    myeloma, and it represents a surrogate for clinical multiple myeloma disease status.[physio-pedia.com] Vitamin D Deficiency in a Man with Multiple Myeloma. N Am J Med Sci. 2011 October; 3(10): 469–471. Available at . Accessed 28 March 2013.[physio-pedia.com] This case highlights that vitamin D deficiency is common in patients with multiple myeloma, and can cause generalized musculoskeletal pain and increase the risk of falls,[physio-pedia.com]

  • Psoriasis

    Giralt and Roy Jones, Complete Remission of Psoriasis After Autologous Hematopoietic Stem-Cell Transplantation for Multiple Myeloma, Journal of Clinical Oncology, 10.1200[dx.doi.org] Occurring predominately in patients middle-aged or older, SCPD is associated with underlying malignancies (most commonly multiple myeloma and IgA monoclonal gammopathy) and[emedicine.com]

  • Senile Osteoporosis

    myeloma, Cushing's disease.[quidel.com] myeloma malabsorption syndromes Pathogenesis in young adulthood, peak bone mass is achieved and this is determined by a number of factors ( e.g., genetics) after this peak[medbullets.com] References: [1] [8] [9] [10] Differential diagnoses Osteomalacia Hyperparathyroidism Metastases Multiple myeloma Intraosseous hemangioma References: [1] The differential diagnoses[amboss.com]

  • Secondary Malnutrition

    Further Reading Blimark C, Holmberg E, Mellqvist UH, et al. (2015) Multiple myeloma and infections: a population‐based study on 9253 multiple myeloma patients.[els.net]

  • Iron Deficiency

    Distinctive physical findings occur in only a small proportion of patients with iron deficiency but include koilonychia (thin, brittle fingernails with the distal half of[cancertherapyadvisor.com] myeloma Myeloproliferative neoplasms (e.g., myelofibrosis) Infections (e.g., HIV ) Though different types of anemia have different causes, the signs and symptoms can be very[labtestsonline.org] Brittle Nails, Even the cutest mani/pedi can’t hide thin, frail fingernails and toenails.[womenshealthmag.com]

  • Sotos Syndrome

    myeloma.[els.net] Tatton‐Brown K, Douglas J, Coleman K et al. (2005a) Multiple mechanisms are implicated in the generation of 5q35 microdeletions in Sotos syndrome.[els.net] […] domain‐containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf‐Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple[els.net]

  • Spinal Cord Irradiation

    Coarse and thinning hair. Brittle fingernails. Hoarse voice. Puffy face. Muscle and joint aches and stiffness. Constipation.[cancer.gov] The type of radiation therapy most often used to treat multiple myeloma or solitary plasmacytoma is called external beam radiation therapy.[cancer.org] myeloma (cancer of plasma cells) These Veterans don't have to prove a connection between these diseases and their service to be eligible for disability compensation .[publichealth.va.gov]

  • Graft-versus-Host-Disease

    Symptoms include: dry, itchy rash a change in skin color thickening of the skin that can restrict joint movement taut skin Skin GVHD may also cause: brittle or splitting fingernails[bmtinfonet.org] Allogeneic blood or marrow transplantation (alloBMT) may lead to long-term disease control in patients with multiple myeloma (MM).[ncbi.nlm.nih.gov] Hematopoietic progenitor cell (HPC) products were available from 8 multiple myeloma patients with biopsy-proven autoGVHD, 16 matched multiple myeloma patients who did not[hindawi.com]

  • Microcytic Anemia

    Brittle or rigid fingernails may be a result of abnormal thinness of nails due to insufficient iron supply.[newworldencyclopedia.org] Bone marrow biopsy will be ultimately required for diagnosis of multiple myeloma but it can miss up to 5% of the cases due to patchy involvement.[clinicaladvisor.com]

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