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33 Possible Causes for Multiple Sclerosis-Like Illness, Optic Disc Pallor, Spastic Dystonia

  • Leber's Hereditary Optic Neuropathy

    It is suggested that multiple sclerosis-like illness and deformities of the vertebral column may be associated pathogenically with Leber's hereditary optic neuropathy.[ncbi.nlm.nih.gov] Fundoscopic examination showed hyperemic papilla on the right eye and optic disc pallor on the left eye.[ncbi.nlm.nih.gov] A MELAS-associated ND1 mutation causing leber hereditary optic neuropathy and spastic dystonia.[ncbi.nlm.nih.gov]

  • Optic Atrophy

    sclerosis-like illness, spastic paraplegia or cataracts.[ncbi.nlm.nih.gov] CONCLUSIONS: Deeply buried ODD may be associated with NAION causing irreversible visual loss and optic disc pallor, a condition easily mistaken for atypical ON.[ncbi.nlm.nih.gov] The disease presented before age 10 with slowly progressive tremor, dystonia, and spasticity.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Optic Atrophy

    Other manifestations have been more rarely associated with ADOA plus, such as multiple sclerosis-like illness, migraine, cardiomyopathy, late-onset diabetes mellitus, and[orpha.net] These patients typically present in the first decade of life with slightly subnormal acuity, dyschromatopsia, central visual field loss, and optic disc pallor.[practicalreviews.com] Other patients have minor neurologic abnormalities, such as a postural tremor, loss of ankle reflexes, dystonia, spasticity, or a multiple sclerosis–like illness.[merckmanuals.com]

  • Primary Optic Atrophy

    Other patients have minor neurologic abnormalities, such as a postural tremor, loss of ankle reflexes, dystonia, spasticity, or a multiple sclerosislike illness.[merckmanuals.com] Differential Diagnosis Optic atrophy versus other causes of optic disc pallor: • Pallor of optic disc in partial optic atrophy must be differentiated from other causes of[slideshare.net] Optic disc pallor is one of the defining characteristics of Dominant Optic Atropy.[webeye.ophth.uiowa.edu]

  • Hereditary Optic Atrophy

    Other patients have minor neurologic abnormalities, such as a postural tremor, loss of ankle reflexes, dystonia, spasticity, or a multiple sclerosislike illness.[merckmanuals.com] There was bilateral optic disc pallor in fundoscopy and his visual accurate was diminished to counting fingers from one meter.[omicsonline.org] dystonia.[genome.jp]

  • Autosomal Dominant Optic Atrophy and Cataract

    Other patients have minor neurologic abnormalities, such as a postural tremor, loss of ankle reflexes, dystonia, spasticity, or a multiple sclerosislike illness.[merckmanuals.com] Optic disc appearance of OPA1 -positive two patients showing bilateral prominent temporal wedge of pallor ( upper ) and total disc pallor ( lower ). ( C ) Optic disc appearance[iovs.arvojournals.org] SPOAN - Spastic Paraplegia, Optic Atrophy, and Neuropathy ADOA - Autosomal Dominant Optic Atrophy CAMOS - Cerebellar Ataxia with Mental Retardation, Optic Atrophy, and Skin[acronymsandslang.com]

  • Autosomal Recessive Spastic Paraplegia Type 46

    sclerosis-like illness, spastic paraplegia or cataracts.[ncbi.nlm.nih.gov] Dystonia, Dopa-responsive, due to sepiapterin reductase deficiency AR 12 23 TH Segawa syndrome, autosomal recessive AR 44 71 ZFYVE26 Spastic paraplegia 15 AR 63 39 * Some,[blueprintgenetics.com] Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia.[ncbi.nlm.nih.gov]

  • Optic Neuropathy

    Some females have a multiple sclerosis-like neurologic illness. Genetics This disorder results from mutations in mitochondrial genes.[disorders.eyes.arizona.edu] , and (f) development of optic disc pallor, usually within 6-8 weeks.[webeye.ophth.uiowa.edu] Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystonia.[jmg.bmj.com]

  • Demyelinating Disease

    Harding A E, Sweeney M G, Miller D H. et al Occurrence of a multiple sclerosislike illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation[ncbi.nlm.nih.gov] […] nerves: mild diffuse optic disc edema OD, no pallor OU, cup:disc 0.3 OU Macula: Normal, no exudates or folds OU Vessels: Normal course and diameter, no hemorrhages OU Periphery[eyerounds.org] Symptoms can come and go in chronic illnesses like multiple sclerosis (MS) and progress over years. Nerves are a key part of your body functions.[healthline.com]

  • Spastic Ataxia with Congenital Miosis

    There may be a past history of episodes of multiple sclerosis or this illness may be the first manifestation of it. The fundus is usually normal.[guwsmedical.info] disc pallor Sensory axonal neuropathy Flexion contracture Limb muscle weakness Progressive spastic paraplegia Scoliosis Motor axonal neuropathy Violent behavior Inertia Exaggerated[mendelian.co] , Angelman syndrome , Ataxia spastic congenital miosis , Ataxia , Athetosis , Autonomic dysreflexia , Autonomic dystonia , Autosomal recessive spastic paraplegia , Bahemuka[wikidoc.org]

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