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250 Possible Causes for Muscle Atrophy, primarily in the legs, Progressive Dementia

  • Amyotrophic Lateral Sclerosis

    Signs and symptoms include muscle weakness, atrophy, and fasciculation.[] A form of progressive dementia called frontotemporal dementia may emerge in some ALS patients.[] […] by often asymmetric and primarily distal LMN involvement in the lower limbs.[]

  • Amyloidosis

    Tubular epithelium can be conserved, but it is frequent that shows some degree of atrophy.[] Alzheimer's disease-like dementia and lobar intracerebral hemorrhage in some patients.[] Amyloid protein deposits often occur primarily in the kidneys and can cause protein in the urine, swelling of the legs and feet and fatigue.[]

  • Muscular Dystrophy

    The axonal form of Charcot-Marie-Tooth disease with late-onset distal weakness and distal forms of chronic spinal muscular atrophy may mimic those of the distal dystrophies[] 76 suggested that a family had DM3 but this was subsequently demonstrated to be an unusual presentation of inclusion body myopathy with Paget's disease and frontotemporal dementia[] […] and hips) in the forearms, hands, lower legs, and feet.[]

  • Amyotrophic Lateral Sclerosis 11

    Muscle weakness is followed by atrophy, and fasciculations are very common, too.[] , Ichikawa K, Tadashi A, Takigawa H, Shibayama H, Takashima H Journal of human genetics 63(3) 281-287 Mar 2018 [Refereed] [Pharmacologic Therapies for Different Types of Dementia[] Agraphia in mobile text messages in a case of amyotrophic lateral sclerosis with frontotemporal dementia. Intern Med 54:3065-3068, 2015.[]

  • Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1

    Symptoms and course In patients with typical ALS, the symptoms are primarily those of weakness, which may start in the hands or legs or be manifested by slurred speech and[] As the disease progresses, people experience increasing cognitive deficits, spasticity, muscle atrophy, and weakness.[] […] that involves progressive dementia and parkinsonism which ultimately leads to death.[]

  • Addison's Disease

    We described a 38-year-old woman of rapidly progressive dementia with white matter encephalopathy and death.[] The following signs and symptoms are typically observed in acute adrenal failure: Lower back pain Abdominal pain Leg pain Severe diarrhea with dehydration Incessant vomiting[] Adrenoleukodystrophy begins in infancy or childhood with weakness and spasticity and progresses to dementia, blindness and quadriparesis.[]

  • Distal Spinal Muscular Atrophy Type 3

    Homepage Rare diseases Search Search for a rare disease X-linked distal spinal muscular atrophy type 3 Disease definition X-linked distal spinal muscular atrophy type 3 is[] The clinical delineation for new syndromes and their genetic bases and of clinical subtypes of known disorders has also progressed.[] This form affects primarily the muscles in the legs.[]

  • Friedreich Ataxia

    atrophy Scoliosis Muscle atrophy Cardiac (91%) Hypertrophic cardiomyopathy leading to arrhythmia (ST-T wave abnormalities) and heart failure Most frequent cause of death[] Program at Tufts Medical Center in Boston to learn more about treating degenerative brain disease and other types of dementia.[] FRDA was first described in 1863 as a disease that is primarily early onset, associated with progressive limb and gait ataxia, absent tendon reflexes from the legs, axonal[]

  • Parkinson's Disease

    Myoung-Ae Choe, Byung-Soo Koo, Gyeong Ju An and Songhee Jeon, Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned[] Parkinson disease (PD) is progressive, with dementia and medication-refractory motor problems common reasons for late-stage nursing-home placement.[] […] affecting the side of onset - Resting tremor (hand, leg or jaw; low frequency [4–5 Hz], asymmetric, disappears with action) - Excellent response to levodopa (70%–100%) -[]

  • Spinal Muscular Atrophy Type 3

    This form affects primarily the muscles in the legs.[] Background Spinal muscle atrophy (SMA; also known as spinal muscular atrophy) is an autosomal recessive hereditary disease characterized by progressive hypotonia and muscular[] ; Primary Lateral Sclerosis; Progressive Muscular Atrophy Intervention : Sponsors : University of Miami; Muscular Dystrophy Association; National Institute of Neurological[]

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