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250 Possible Causes for Muscle Atrophy, primarily in the legs, Progressive Dementia

  • Amyotrophic Lateral Sclerosis

    Signs and symptoms include muscle weakness, atrophy, and fasciculation.[icd10data.com] A form of progressive dementia called frontotemporal dementia may emerge in some ALS patients.[med.unc.edu] […] by often asymmetric and primarily distal LMN involvement in the lower limbs.[doi.org]

  • Amyloidosis

    Tubular epithelium can be conserved, but it is frequent that shows some degree of atrophy.[kidneypathology.com] Alzheimer's disease-like dementia and lobar intracerebral hemorrhage in some patients.[orpha.net] Amyloid protein deposits often occur primarily in the kidneys and can cause protein in the urine, swelling of the legs and feet and fatigue.[froedtert.com]

  • Muscular Dystrophy

    The axonal form of Charcot-Marie-Tooth disease with late-onset distal weakness and distal forms of chronic spinal muscular atrophy may mimic those of the distal dystrophies[ncbi.nlm.nih.gov] 76 suggested that a family had DM3 but this was subsequently demonstrated to be an unusual presentation of inclusion body myopathy with Paget's disease and frontotemporal dementia[doi.org] […] and hips) in the forearms, hands, lower legs, and feet.[web.archive.org]

  • Amyotrophic Lateral Sclerosis 11

    Muscle weakness is followed by atrophy, and fasciculations are very common, too.[symptoma.com] , Ichikawa K, Tadashi A, Takigawa H, Shibayama H, Takashima H Journal of human genetics 63(3) 281-287 Mar 2018 [Refereed] [Pharmacologic Therapies for Different Types of Dementia[researchmap.jp] Agraphia in mobile text messages in a case of amyotrophic lateral sclerosis with frontotemporal dementia. Intern Med 54:3065-3068, 2015.[higashiomi.hosp.go.jp]

  • Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1

    Symptoms and course In patients with typical ALS, the symptoms are primarily those of weakness, which may start in the hands or legs or be manifested by slurred speech and[alzheimer-europe.org] As the disease progresses, people experience increasing cognitive deficits, spasticity, muscle atrophy, and weakness.[secure.ssa.gov] […] that involves progressive dementia and parkinsonism which ultimately leads to death.[checkorphan.org]

  • Addison's Disease

    We described a 38-year-old woman of rapidly progressive dementia with white matter encephalopathy and death.[ncbi.nlm.nih.gov] The following signs and symptoms are typically observed in acute adrenal failure: Lower back pain Abdominal pain Leg pain Severe diarrhea with dehydration Incessant vomiting[symptoma.com] Adrenoleukodystrophy begins in infancy or childhood with weakness and spasticity and progresses to dementia, blindness and quadriparesis.[pedclerk.bsd.uchicago.edu]

  • Distal Spinal Muscular Atrophy Type 3

    Homepage Rare diseases Search Search for a rare disease X-linked distal spinal muscular atrophy type 3 Disease definition X-linked distal spinal muscular atrophy type 3 is[orpha.net] The clinical delineation for new syndromes and their genetic bases and of clinical subtypes of known disorders has also progressed.[books.google.com] This form affects primarily the muscles in the legs.[mda.org]

  • Friedreich Ataxia

    atrophy Scoliosis Muscle atrophy Cardiac (91%) Hypertrophic cardiomyopathy leading to arrhythmia (ST-T wave abnormalities) and heart failure Most frequent cause of death[pedclerk.bsd.uchicago.edu] Program at Tufts Medical Center in Boston to learn more about treating degenerative brain disease and other types of dementia.[tuftsmedicalcenter.org] FRDA was first described in 1863 as a disease that is primarily early onset, associated with progressive limb and gait ataxia, absent tendon reflexes from the legs, axonal[doi.org]

  • Parkinson's Disease

    Myoung-Ae Choe, Byung-Soo Koo, Gyeong Ju An and Songhee Jeon, Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned[dx.doi.org] Parkinson disease (PD) is progressive, with dementia and medication-refractory motor problems common reasons for late-stage nursing-home placement.[ncbi.nlm.nih.gov] […] affecting the side of onset - Resting tremor (hand, leg or jaw; low frequency [4–5 Hz], asymmetric, disappears with action) - Excellent response to levodopa (70%–100%) -[dx.doi.org]

  • Spinal Muscular Atrophy Type 3

    This form affects primarily the muscles in the legs.[mda.org] Background Spinal muscle atrophy (SMA; also known as spinal muscular atrophy) is an autosomal recessive hereditary disease characterized by progressive hypotonia and muscular[emedicine.medscape.com] ; Primary Lateral Sclerosis; Progressive Muscular Atrophy Intervention : Sponsors : University of Miami; Muscular Dystrophy Association; National Institute of Neurological[treat-nmd.eu]

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