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190 Possible Causes for Muscle Atrophy, primarily in the legs, Progressive Dementia

  • Chronic Inflammatory Demyelinating Polyneuropathy

    atrophy, whereas the upper and lower limbs tended to be equally affected in patients without muscle atrophy.[] Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[] Incidence of Clinical Characteristics of AIDP Clinical Characteristic Incidence Weakness 100% Primarily distal weakness 55% Primarily proximal weakness 15% Hyporeflexia/areflexia[]

  • Addison's Disease

    This crisis occurs primarily with physiologic stress or when corticosteroid therapy is withdrawn without tapering the dose.[] We described a 38-year-old woman of rapidly progressive dementia with white matter encephalopathy and death.[] Patients with Addison’s Disease may present acutely in Addisonian crisis that involve sudden sharp leg pain, lower back or abdominal pain, nausea, vomiting, hyponatremic dehydration[]

  • Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1

    As the disease progresses, people experience increasing cognitive deficits, spasticity, muscle atrophy, and weakness.[] […] that involves progressive dementia and parkinsonism which ultimately leads to death.[] Symptoms and course In patients with typical ALS, the symptoms are primarily those of weakness, which may start in the hands or legs or be manifested by slurred speech and[]

  • Amyotrophic Lateral Sclerosis 11

    Muscle weakness is followed by atrophy, and fasciculations are very common, too.[] Progressive muscle weakness and atrophy eventually leads to respiratory paralysis and death.[] In general, ALS patients are known to primarily experience muscle weakness, which may initially be limited to a single arm or leg, or to the laryngeal and pharyngeal muscles[]

  • Syringomyelia

    We report the very unusual case of a 50-year-old Latino man who developed severe distal muscle atrophy and bulbar dysfunction as a result of Chiari malformation type I with[] The progressive dementia can be arrested by adequate treatment.[] Extension of the syrinx into the lumbar region and involvement of the legs.[]

  • Myotonia Congenita

    A 48-year-old man, from consanguineous parents, presented with a fixed muscle weakness, muscle atrophy, and a cognitive impairment.[] The clinical delineation for new syndromes and their genetic bases and of clinical subtypes of known disorders has also progressed.[] Muscle tissue is composed primarily of contractile cells. Contractile cells have the ability to produce movement.[]

  • Distal Myopathy

    Distal myopathies are a heterogeneous group of disorders characterized by progressive weakness and muscular atrophy, beginning in distal limb muscles and affecting proximal[] Three distal myopathy patients developed rapidly progressive dementia, became bedridden and died of cachexia and pneumonia and VCP gene mutation P137L (c.410C T) was then[] We report on a German family presenting with a predominantly distal myopathy primarily affecting anterior compartments of lower legs in childhood.[]

  • Spinal Muscular Atrophy Type 3

    […] fibres Signs of muscle weakness and/or wastage Neural Cell Transplants for Spinal Muscular Atrophy The underlying cause of SMA is a missing or severely mutated gene known[] ; Primary Lateral Sclerosis; Progressive Muscular Atrophy Intervention : Sponsors : University of Miami; Muscular Dystrophy Association; National Institute of Neurological[] This form affects primarily the muscles in the legs.[]

  • Lyme Disease

    The physical examination showed widespread weakness, atrophy, fasciculation, and brisk reflexes.[] Causes In the United States, Lyme disease is caused by the bacteria Borrelia burgdorferi and Borrelia mayonii, carried primarily by black-legged or deer ticks.[] A 64-year-old man presented with a 1-month history of rapidly progressive weakness involving bulbar, upper limb and lower limb muscles.[]

  • Postpoliomyelitis Syndrome

    Treatment is primarily limited to adequate rest, conservation of available energy, and supportive measures, such as leg braces and energy-saving devices such as powered wheelchairs[] In some cases, muscle atrophy (muscle wasting) also occurs as part of PPS.[] Prevention and AD References Introduction Vascular Cognitive ImpairmentVascular Dementia Lewy Body Disease Dementia with Lewy Bodies Progressive Supranuclear Palsy Corticobasal[]

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